Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Clyde L, Denis"'
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Abstract In eukaryotic translation the 60S ribosome subunit has not been proposed to interact with mRNA or closed-loop factors eIF4E, eIF4G, and PAB1. Using analytical ultracentrifugation with fluorescent detection system, we have identified a 57S tr
Externí odkaz:
https://doaj.org/article/f913d2dae08f435f983fd4a9a50939cb
Publikováno v:
Proteins
Prions, misfolded proteins that aggregate, cause an array of progressively deteriorating conditions to which, currently, there are no effective treatments. The presently accepted model indicates that the soluble non-prion forms of prion-forming prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7574ea5cd6be99c44fd872ec6ab71212
https://doi.org/10.1002/prot.26282
https://doi.org/10.1002/prot.26282
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150616 (2016)
Protein synthesis is a highly efficient process and is under exacting control. Yet, the actual abundance of translation factors present in translating complexes and how these abundances change during the transit of a ribosome across an mRNA remains u
Externí odkaz:
https://doaj.org/article/4df0c9c4bf9843f6a56b654a73ae8063
Autor:
Clyde L. Denis
Publikováno v:
Utah Historical Quarterly. 84:329-346
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4805d958e544f642c981199f098eb996
https://doi.org/10.5406/utahhistquar.84.4.0329
https://doi.org/10.5406/utahhistquar.84.4.0329
Publikováno v:
Proteins. 86(2)
The eukaryotic eRF1 translation termination factor plays an important role in recognizing stop codons and initiating the end to translation. However, which exact complexes contain eRF1 and at what abundance is not clear. We have used analytical ultra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed397aa84a0f5702fa06ca97f820233d
https://pubmed.ncbi.nlm.nih.gov/29139201
https://pubmed.ncbi.nlm.nih.gov/29139201
Autor:
Clyde L. Denis, Thomas M. Laue, Wen Xi, Shiwha Park, Chongxu Zhang, Yueh Chin Chiang, Xin Wang
Publikováno v:
Protein Science. 23:1036-1049
We have previously identified 55 nonribosomal proteins in PAB1-mRNP complexes in Saccharomyces cerevisiae using mass spectrometric analysis. Because one of the inherent limitations of mass spectrometry is that it does not inform as to the size or typ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8ce024bd87ee19395f34857d8445d79
https://doi.org/10.1002/pro.2490
https://doi.org/10.1002/pro.2490
Autor:
Darren J. Lee, Xin Wang, Chongxu Zhang, Roy Richardson, Clyde L. Denis, Thomas M. Laue, Yueh-Chin Chiang, Shiwha Park
Publikováno v:
Molecular Genetics and Genomics. 288:401-412
The poly(A)-binding protein PAB1 from the yeast Saccharomyces cerevisiae plays an important role in controlling mRNA deadenylation rates. Deletion of either its RRM1 or proline-rich domain (P domain) severely restricts deadenylation and slows mRNA de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd6e0f2310a950483f7069f2fa9d77a7
https://doi.org/10.1007/s00438-013-0759-3
https://doi.org/10.1007/s00438-013-0759-3
Publikováno v:
Scientific Reports
Huntington’s disease (HD) results from expansions of polyglutamine stretches (polyQ) in the huntingtin protein (Htt) that promote protein aggregation, neurodegeneration, and death. Since the diversity and sizes of the soluble Htt-polyQ aggregates t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19fe727bffbbb5c3c04fe641a8b237b4
https://pubmed.ncbi.nlm.nih.gov/27721444
https://pubmed.ncbi.nlm.nih.gov/27721444
Autor:
CLYDE L. DENIS
Publikováno v:
Utah Historical Quarterly. 80:354-373
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::024a42bebb9b0eb5fbb23439ac100a52
https://doi.org/10.2307/45063655
https://doi.org/10.2307/45063655
Autor:
Darren J. Lee, Chongxu Zhang, Thomas M. Laue, Roy Richardson, Mitchell E. Granoff, Wen Xi, Matthew P. Power, Susan F. Chase, Shaun Toomey, Yueh-Chin Chiang, Xin Wang, Clyde L. Denis
Publikováno v:
Protein Science. 21:1253-1268
A fundamental problem in proteomics is the identification of protein complexes and their components. We have used analytical ultracentrifugation with a fluorescence detection system (AU-FDS) to precisely and rapidly identify translation complexes in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d05c81e016fc2cd2f4ffce1440e4774
https://doi.org/10.1002/pro.2110
https://doi.org/10.1002/pro.2110