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BET bromodomain inhibition potentiates radiosensitivity in models of H3K27-altered diffuse midline glioma.

Autor: Watanabe J; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Division of Hematology, Oncology, Neuro-Oncology and Stem Cell Transplantation, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.; Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA.; Department of Neurological Surgery, Brain Research Institute, Niigata University, Niigata, Japan., Clutter MR; Department of Molecular Biosciences., Gullette MJ; High Throughput Analysis Laboratory, and., Sasaki T; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Department of Neurological Surgery, Wakayama Medical University, Wakayama, Japan., Uchida E; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Division of Hematology, Oncology, Neuro-Oncology and Stem Cell Transplantation, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.; Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA., Kaur S; Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA., Mo Y; Institute for Cancer Genetics.; Department of Pediatrics, and.; Department of Genetics and Development, Columbia University Irving Medical Center, New York, New York, USA., Abe K; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Division of Hematology, Oncology, Neuro-Oncology and Stem Cell Transplantation, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA., Ishi Y; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Division of Hematology, Oncology, Neuro-Oncology and Stem Cell Transplantation, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA., Takata N; Center for Vascular and Developmental Biology, Feinberg Cardiovascular and Renal Research Institute, and.; Simpson Querrey Institute for BioNanotechnology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Natsumeda M; Department of Neurological Surgery, Brain Research Institute, Niigata University, Niigata, Japan., Gadd S; Division of Hematology, Oncology, Neuro-Oncology and Stem Cell Transplantation, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA., Zhang Z; Institute for Cancer Genetics.; Department of Pediatrics, and.; Department of Genetics and Development, Columbia University Irving Medical Center, New York, New York, USA., Becher OJ; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Hashizume R; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Division of Hematology, Oncology, Neuro-Oncology and Stem Cell Transplantation, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.; Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA.; Division of Pediatric Hematology and Oncology, Children's of Alabama, Birmingham, Alabama, USA.; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2024 May 21; Vol. 134 (13). Date of Electronic Publication: 2024 May 21.

Synergistic PIM kinase and proteasome inhibition as a therapeutic strategy for MYC-overexpressing triple-negative breast cancer.

Autor: Kunder R; Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Velyunskiy M; Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Adlai E. Stevenson High School, Lincolnshire, IL 60069, USA., Dunne SF; High-Throughput Analysis Laboratory, Chemistry of Life Processes Institute, Northwestern University, Evanston, IL 60208, USA., Cho BK; Proteomics Center for Excellence, Northwestern University, Chicago, IL 60611, USA., Kanojia D; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Begg L; Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Orriols AM; Department of Radiation Oncology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Fleming-Trujillo E; Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Vadlamani P; Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Vialichka A; Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Bolin R; Center for Comparative Medicine, Northwestern University, Chicago, IL 60611, USA., Perrino JN; Center for Comparative Medicine, Northwestern University, Chicago, IL 60611, USA., Roth D; Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Clutter MR; High-Throughput Analysis Laboratory, Chemistry of Life Processes Institute, Northwestern University, Evanston, IL 60208, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA., Zielinski-Mozny NA; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Center for Comparative Medicine, Northwestern University, Chicago, IL 60611, USA., Goo YA; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Proteomics Center for Excellence, Northwestern University, Chicago, IL 60611, USA., Cristofanilli M; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA., Mendillo ML; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Simpson Querrey Institute for Epigenetics, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA., Vassilopoulos A; Department of Radiation Oncology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA., Horiuchi D; Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA. Electronic address: dai.horiuchi@northwestern.edu.

Publikováno v: Cell chemical biology [Cell Chem Biol] 2022 Mar 17; Vol. 29 (3), pp. 358-372.e5. Date of Electronic Publication: 2021 Sep 14.

Modeling MEK4 Kinase Inhibitors through Perturbed Electrostatic Potential Charges.

Autor: Mishra RK; Center for Molecular Innovation and Drug Discovery , Northwestern University , 2145 Sheridan Road , Evanston , Illinois 60208 , United States.; Department of Pharmacology, Feinberg School of Medicine , Northwestern University , Chicago , Illinois 60611 , United States., Deibler KK; Department of Chemistry , Northwestern University , Evanston , Illinois 60208 , United States., Clutter MR; Chemistry of Life Processes Institute , Northwestern University , 2145 Sheridan Road , Evanston , Illinois 60208 , United States.; Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine , Northwestern University , Chicago , Illinois 60611 , United States., Vagadia PP; Center for Molecular Innovation and Drug Discovery , Northwestern University , 2145 Sheridan Road , Evanston , Illinois 60208 , United States., O'Connor M; Department of Chemistry , Northwestern University , Evanston , Illinois 60208 , United States., Schiltz GE; Center for Molecular Innovation and Drug Discovery , Northwestern University , 2145 Sheridan Road , Evanston , Illinois 60208 , United States.; Department of Pharmacology, Feinberg School of Medicine , Northwestern University , Chicago , Illinois 60611 , United States.; Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine , Northwestern University , Chicago , Illinois 60611 , United States., Bergan R; Knight Cancer Institute , Oregon Health & Science University , Portland , Oregon 97239 , United States., Scheidt KA; Center for Molecular Innovation and Drug Discovery , Northwestern University , 2145 Sheridan Road , Evanston , Illinois 60208 , United States.; Department of Pharmacology, Feinberg School of Medicine , Northwestern University , Chicago , Illinois 60611 , United States.; Department of Chemistry , Northwestern University , Evanston , Illinois 60208 , United States.; Chemistry of Life Processes Institute , Northwestern University , 2145 Sheridan Road , Evanston , Illinois 60208 , United States.; Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine , Northwestern University , Chicago , Illinois 60611 , United States.

Publikováno v: Journal of chemical information and modeling [J Chem Inf Model] 2019 Oct 28; Vol. 59 (10), pp. 4460-4466. Date of Electronic Publication: 2019 Oct 14.

Synthesis and Biological Evaluation of 3-Arylindazoles as Selective MEK4 Inhibitors.

Autor: Deibler KK; Department of Chemistry, Northwestern University, Evanston, IL, 60208, USA., Schiltz GE; Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, IL, 60208, USA.; Department of Pharmacology, Northwestern University, Chicago, IL, 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA., Clutter MR; Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.; Chemistry of Life Process Institute, Northwestern University, Evanston, IL, 60208, USA.; Department of Molecular Biosciences, Northwestern University, Evanston, IL, 60208, USA., Mishra RK; Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, IL, 60208, USA.; Department of Pharmacology, Northwestern University, Chicago, IL, 60611, USA., Vagadia PP; Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, IL, 60208, USA., O'Connor M; Department of Chemistry, Northwestern University, Evanston, IL, 60208, USA., George MD; Chemistry of Life Process Institute, Northwestern University, Evanston, IL, 60208, USA., Gordon R; Knight Cancer Institute, Oregon Health & Science University, Portland, OR, 97239, USA., Fowler G; Knight Cancer Institute, Oregon Health & Science University, Portland, OR, 97239, USA., Bergan R; Knight Cancer Institute, Oregon Health & Science University, Portland, OR, 97239, USA., Scheidt KA; Department of Chemistry, Northwestern University, Evanston, IL, 60208, USA.; Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, IL, 60208, USA.; Department of Pharmacology, Northwestern University, Chicago, IL, 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.; Chemistry of Life Process Institute, Northwestern University, Evanston, IL, 60208, USA.

Publikováno v: ChemMedChem [ChemMedChem] 2019 Mar 22; Vol. 14 (6), pp. 615-620. Date of Electronic Publication: 2019 Feb 19.