Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Cluff, Christopher W"'
Autor:
Hélène G. Bazin, Craig L. Johnson, Steven P. Fling, Mark T. Livesay, William S. Bowen, Tim J. Murray, Afsaneh Mozaffarian, Johnson David A, Laura S. Bess, Kendal T. Ryter, Cluff Christopher W, Jeffrey S. Arnold, Jay T. Evans
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5350-5354
To overcome the chemical and metabolic instability of the secondary fatty acyl residues in the AGP class of lipid A mimetics, the secondary ether lipid analogs of the potent TLR4 agonist CRX-527 (2) and TLR4 antagonist CRX-526 (3) were synthesized an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26336b5880d479f03de5bf3b9b911321
https://doi.org/10.1016/j.bmcl.2008.09.060
https://doi.org/10.1016/j.bmcl.2008.09.060
Autor:
Richard J. Ulevitch, Michael J. Lacy, Jean da Silva Correia, Jory R. Baldridge, Eric W. Jeffery, Peter Probst, Cluff Christopher W, Axel G. Stöver, Johnson David A, Mark Elliott, Robert M. Hershberg, David H. Persing, Jay T. Evans
Publikováno v:
Journal of Biological Chemistry. 279:4440-4449
Important questions remain regarding the impact of variations in the structure of the lipid A portion of lipopolysaccharide on activation of cells via the Toll-like receptor 4 complex. We have studied a series of synthetic lipid A mimetic compounds k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7713931baa349efd90248c15ef4ea9fa
https://doi.org/10.1074/jbc.m310760200
https://doi.org/10.1074/jbc.m310760200
Autor:
Jeffrey R. Stephens, Jay T. Evans, Johnson David A, Cluff Christopher W, David H. Persing, Jon R. Ward, Rong Wang, Yvonne M. Yorgensen, Michael J. Lacy, Valerie G. Brookshire, Jory R. Baldridge
Publikováno v:
Journal of Endotoxin Research. 8:453-458
Earlier we showed that the structural requirements for adjuvanticity among the aminoalkyl glucosaminide 4-phosphate (AGP) class of synthetic immunostimulants may be less strict than those for other endotoxic activities, including the induction of nit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af625cfdd022e1ae3c6de63e3797dc6
https://doi.org/10.1179/096805102125001064
https://doi.org/10.1179/096805102125001064
Autor:
Cluff Christopher W
Publikováno v:
Lipid A in Cancer Therapy ISBN: 9781441916020
As technological advances allow for the identification of tumor-associated antigens (TAAs) against which adaptive immune responses can be raised, efforts to develop vaccines for the treatment of cancer continue to gain momentum. Some of these vaccine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2d3735d67704a66191aaeedfa46d848
https://doi.org/10.1007/978-1-4419-1603-7_10
https://doi.org/10.1007/978-1-4419-1603-7_10
Autor:
Johnson David A, Myers Kent R, Jory R. Baldridge, David H. Persing, Cluff Christopher W, Robert M. Hershberg
Publikováno v:
Vaccine Adjuvants ISBN: 9780896038929
MPL adjuvant, a monophosphoryl lipid A (MLA) derivative of the lipopolysaccharide (LPS) from Salmonella minnesota R595, and RC-529, a synthetic lipid A mimetic, are promising adjuvant candidates for a number of human vaccines and have been shown to b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8ea7f40bc88385dca4e81768ca61dc7
https://doi.org/10.1007/978-1-59259-970-7_12
https://doi.org/10.1007/978-1-59259-970-7_12
Autor:
Axel G. Stöver, Johnson David A, Robert M. Hershberg, Michael J. Lacy, Jay T. Evans, David H. Persing, Vonnie M. Yorgensen, Cluff Christopher W, Valerie G. Clawson, Craig L. Johnson, Jory R. Baldridge, Mark T. Livesay
Publikováno v:
Infection and immunity. 73(5)
A compound family of synthetic lipid A mimetics (termed the aminoalkyl glucosaminide phosphates [AGPs]) was evaluated in murine infectious disease models of protection against challenge with Listeria monocytogenes and influenza virus. For the Listeri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e050cdb468bccd9e870a837ab8a0317
https://pubmed.ncbi.nlm.nih.gov/15845512
https://pubmed.ncbi.nlm.nih.gov/15845512
Autor:
Jory R. Baldridge, Patrick Mcgowan, Sally Mossman, Jay T. Evans, David H. Persing, Cluff Christopher W, Johnson David A
Publikováno v:
Expert opinion on biological therapy. 4(7)
Toll-like receptor (TLR) agonists are being developed for use as vaccine adjuvants and as stand-alone immunomodulators because of their ability to stimulate innate and adaptive immune responses. Among the most thoroughly studied TLR agonists are the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a579f0867304a59be8e71be617801a7c
https://pubmed.ncbi.nlm.nih.gov/15268679
https://pubmed.ncbi.nlm.nih.gov/15268679
Autor:
Jory R. Baldridge, Johnson David A, David H. Persing, Michael J. Lacy, Cluff Christopher W, Jay T. Evans
Publikováno v:
Expert review of vaccines. 2(2)
MPL (Corixa) adjuvant is a chemically modified derivative of lipopolysaccharide that displays greatly reduced toxicity while maintaining most of the immunostimulatory activity of lipopolysaccharide. MPL adjuvant has been used extensively in clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ea2e921837e8596a11a48eaef448dab
https://pubmed.ncbi.nlm.nih.gov/12899573
https://pubmed.ncbi.nlm.nih.gov/12899573
Autor:
Bazin, Hélène G., Murray, Tim J., Bowen, William S., Mozaffarian, Afsaneh, Fling, Steven P., Bess, Laura S., Livesay, Mark T., Arnold, Jeffrey S., Johnson, Craig L., Ryter, Kendal T., Cluff, Christopher W., Evans, Jay T., Johnson, David A.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2008 18(20):5350-5354
Autor:
Baldridge, Jory R., Cluff, Christopher W., Evans, Jay T., Lacy, Michael J., Stephens, Jeffrey R., Brookshire, Valerie G., Rong Wang, Ward, Jon R., Yorgensen, Yvonne M., Persing, David H., Johnson, David A.
Publikováno v:
Innate Immunity; Dec2002, Vol. 8 Issue 6, p453-458, 6p