Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Cloudius R. Sagandira"'
Publikováno v:
Arabian Journal of Chemistry, Vol 13, Iss 11, Pp 7886-7908 (2020)
The realization of a downward spiralling of diseases in developing countries requires them to become self-sufficient in pharmaceutical products. One of the ways to meet this need is by boosting the local production of active pharmaceutical ingredient
Externí odkaz:
https://doaj.org/article/cff6a4511e9e460e9e727663dc827dc9
Autor:
Cloudius R. Sagandira, Paul Watts
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 2577-2589 (2019)
Tamiflu is one of the most effective anti-influenza drugs, which is currently manufactured by Hoffmann-La Roche from shikimic acid. Owing to its importance, more than 60 synthetic routes have been developed to date, however, most of the synthetic rou
Externí odkaz:
https://doaj.org/article/1389112cfd4e4d9ab087e2dd8cf1dab0
Autor:
Cloudius R. Sagandira, Sinazo Nqeketo, Kanyisile Mhlana, Thembela Sonti, Sibongiseni Gaqa, Paul Watts
Publikováno v:
Reaction Chemistry & Engineering. 7:214-244
The convergence of end-to-end continuous flow synthesis with downstream processing, process analytical technology (PAT), artificial intelligence (AI), machine learning and automation in ensuring improved accessibility of quality medicines on demand.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d863e9e5929d14a7e5e3dafba3d5358b
https://doi.org/10.1039/d1re00483b
https://doi.org/10.1039/d1re00483b
Publikováno v:
Chemistry – A European Journal. 27:16028-16035
Glipizide and glibenclamide remain some of the widely prescribed antidiabetic sulfonylurea drugs for the treatment of type 2 diabetes mellitus. Herein the authors report on an isocyanate-free synthetic procedure towards the preparation of these on de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d56dbb9749868431401058c89e55977
https://doi.org/10.1002/chem.202103196
https://doi.org/10.1002/chem.202103196
Autor:
Cloudius R. Sagandira, Paul Watts
Publikováno v:
Synthesis. 54:1365-1374
A multigram-scale robust, efficient, and safe end-to-end continuous-flow process for the diabetes sulfonylurea drugs gliclazide, chlorpropamide, and tolbutamide is reported. The drugs were prepared by the treatment of an amine with a haloformate affo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3c1f4d190be9e6209dea4ebf434ef76
https://doi.org/10.1055/a-1664-2282
https://doi.org/10.1055/a-1664-2282
Publikováno v:
The Journal of Organic Chemistry. 86:13934-13942
Herein, we demonstrate an elegant multistep continuous flow synthesis for stavudine (d4T), a potent nucleoside chemotherapeutic agent for human immunodeficiency virus, acquired immunodeficiency syndrome (AIDS) and AIDS-related conditions. This was ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::986b1a7445fea116b05a5369c705e17c
https://doi.org/10.1021/acs.joc.1c01013
https://doi.org/10.1021/acs.joc.1c01013
Publikováno v:
Journal of Flow Chemistry. 11:193-208
Herein, we disclose the continuous flow synthesis of xylidines via biphasic nitration of xylenes followed by nitro-reduction in various continuous flow systems, demonstrating that mass transfer greatly influences conversion and product selectivity. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::066dc45c814304addb62854592db0bce
https://doi.org/10.1007/s41981-020-00134-1
https://doi.org/10.1007/s41981-020-00134-1
Publikováno v:
Arabian Journal of Chemistry, Vol 13, Iss 11, Pp 7886-7908 (2020)
Arabian Journal of Chemistry
Arabian Journal of Chemistry
The realization of a downward spiralling of diseases in developing countries requires them to become self-sufficient in pharmaceutical products. One of the ways to meet this need is by boosting the local production of active pharmaceutical ingredient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee5249b1f4849a80c9330f3b99094a79
http://www.sciencedirect.com/science/article/pii/S1878535220303440
http://www.sciencedirect.com/science/article/pii/S1878535220303440
Publikováno v:
Arkivoc. 2020:49-63
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18b490d9e510d262d39a9309a8ff62e0
https://doi.org/10.24820/ark.5550190.p011.226
https://doi.org/10.24820/ark.5550190.p011.226
Publikováno v:
Arkivoc. 2020:24-39
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::028ffddd6423ca32ae9f971c76b76845
https://doi.org/10.24820/ark.5550190.p011.214
https://doi.org/10.24820/ark.5550190.p011.214