Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Clotilde Guidetti"'
Autor:
Nicola Ferri, Sara De Martin, James Stuart, Sergio Traversa, Andrea Mattarei, Stefano Comai, Franco Folli, Marco Pappagallo, Clotilde Guidetti, Charles E. Inturrisi, Paolo L. Manfredi
Publikováno v:
Drugs in R&D, Vol 24, Iss 2, Pp 341-352 (2024)
Abstract Background and Objectives Esmethadone (dextromethadone; d-methadone; S-methadone (+)-methadone; REL-1017) is a low potency N-methyl-D-aspartate (NMDA) receptor channel blocker that showed a rapid and sustained adjunctive antidepressant effec
Externí odkaz:
https://doaj.org/article/54082aea68a3451ba1202c9e94b535ab
Autor:
Nicola Ferri, Sara De Martin, James Stuart, Sergio Traversa, Franco Folli, Marco Pappagallo, Cedric O’Gorman, Clotilde Guidetti, Andrea Mattarei, Charles E. Inturrisi, Paolo L. Manfredi
Publikováno v:
Drugs in R&D, Vol 24, Iss 1, Pp 51-68 (2023)
Abstract Background and Objective Esmethadone (dextromethadone; d-methadone; S-methadone (+)-methadone; REL-1017) is the opioid inactive dextro-isomer of racemic methadone. Esmethadone is a low potency N-methyl-D-aspartate (NMDA) receptor channel blo
Externí odkaz:
https://doaj.org/article/9a07ec79820f4842b2bf83183c3444df
Autor:
Megan J. Shram, Jack E. Henningfield, Glen Apseloff, Charles W. Gorodetzky, Sara De Martin, Frank L. Vocci, Frank L. Sapienza, Thomas R. Kosten, Jeff Huston, August Buchhalter, Judy Ashworth, Ryan Lanier, Franco Folli, Andrea Mattarei, Clotilde Guidetti, Stefano Comai, Cedric O’Gorman, Sergio Traversa, Charles E. Inturrisi, Paolo L. Manfredi, Marco Pappagallo
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Esmethadone (REL-1017) is the opioid-inactive dextro-isomer of methadone and a low-affinity, low-potency uncompetitive NMDA receptor antagonist. In a Phase 2, randomized, double-blind, placebo-controlled trial, esmethadone showed rapid, robu
Externí odkaz:
https://doaj.org/article/b958bfa2946e4409a7e15362350d0462
Autor:
Ida Turrini, Clotilde Guidetti, Ilaria Contaldo, Silvia Pulitanò, Donato Rigante, Chiara Veredice
Publikováno v:
Diseases, Vol 12, Iss 6, p 112 (2024)
Background: Wernicke encephalopathy (WE) is an acute and potentially fatal neuropsychiatric disorder resulting from thiamine deficiency: its etiology and clinical presentation can be heterogeneous and arduously recognized, especially in children and
Externí odkaz:
https://doaj.org/article/88422ba52c18437b93b0ad9ad22d7b36
Autor:
Massimo Apicella, Giulia Serra, Monia Trasolini, Elisa Andracchio, Fabrizia Chieppa, Roberto Averna, Maria Elena Iannoni, Antonio Infranzi, Marianna Moro, Clotilde Guidetti, Gino Maglio, Umberto Raucci, Antonino Reale, Stefano Vicari
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2023)
IntroductionSuicidal attempts (SAs) in youth have been increasing during the last decades.MethodsWe studied consultations, SA, and suicidal ideation (SI) in a pediatric emergency department (ED).ResultsFrom 1 January 2011 to 31 May 2022, 606,159 pati
Externí odkaz:
https://doaj.org/article/ffe811fbbe6142c881a6ba046a0ceda3
Autor:
Vicari, Giulia Serra, Massimo Apicella, Maria Elena Iannoni, Monia Trasolini, Elisa Andracchio, Fabrizia Chieppa, Roberto Averna, Clotilde Guidetti, Gino Maglio, Antonino Reale, Stefano
Publikováno v:
Journal of Personalized Medicine; Volume 13; Issue 7; Pages: 1112
Access to the emergency department (ED) for acute psychiatric problems, especially for suicide attempts (SA), has increased in the last decade. This increase has exceptionally accelerated after the COVID-19 pandemic. The aim of this project was to st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::c37c5bf5cfb29ba061f78cd5bc7b2485
Autor:
Clotilde Guidetti, Giulia Serra, Luca Pani, Marco Pappagallo, Gino Maglio, Sara De Martin, Andrea Mattarei, Franco Folli, Paolo L. Manfredi, Maurizio Fava
Publikováno v:
The Primary Care Companion For CNS Disorders. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22afb39b687d058b98202ad06b4fef9f
https://doi.org/10.4088/pcc.22m03267
https://doi.org/10.4088/pcc.22m03267
Autor:
Stephen M. Stahl, Sara De Martin, Andrea Mattarei, Ezio Bettini, Luca Pani, Clotilde Guidetti, Franco Folli, Marc de Somer, Sergio Traversa, Charles E. Inturrisi, Marco Pappagallo, Marco Gentilucci, Andrea Alimonti, Maurizio Fava, Paolo L. Manfredi
Publikováno v:
International journal of molecular sciences. 23(20)
This article presents a mechanism of action hypothesis to explain the rapid antidepressant effects of esmethadone (REL-1017) and other uncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonists and presents a corresponding mechanism of disease h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0fe0241bab471f5831d3743e5cbf36d
https://pubmed.ncbi.nlm.nih.gov/36293063
https://pubmed.ncbi.nlm.nih.gov/36293063
Autor:
Maurizio Fava, Stephen Stahl, Luca Pani, Sara De Martin, Marco Pappagallo, Clotilde Guidetti, Andrea Alimonti, Ezio Bettini, Richard M. Mangano, Thomas Wessel, Marc de Somer, Judy Caron, Ottavio V. Vitolo, Gina R. DiGuglielmo, Adam Gilbert, Hiren Mehta, Morgan Kearney, Andrea Mattarei, Marco Gentilucci, Franco Folli, Sergio Traversa, Charles E. Inturrisi, Paolo L. Manfredi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c1a521b8ae328a89b18e52662a6765c
http://hdl.handle.net/11577/3415641
http://hdl.handle.net/11577/3415641
Autor:
Clotilde Guidetti, Maurizio Fava, Luca Pani, Marco Pappagallo, Giulia Serra, Sara DeMartin, Andrea Mattarei, Paolo L. Manfredi
BackgroundMajor depressive disorder (MDD) is the second leading cause of disability and chronic disease burden in the United States. The importance of improving functional outcomes in MDD is increasingly recognized. The Symptoms of Depression Questio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27cf881c7c32ec4a75081b20ca5a7744
https://hdl.handle.net/11380/1279840
https://hdl.handle.net/11380/1279840