MEIOB targets single-strand DNA and is necessary for meiotic recombination.

Autor: Benoit Souquet, Emilie Abby, Roxane Hervé, Friederike Finsterbusch, Sophie Tourpin, Ronan Le Bouffant, Clotilde Duquenne, Sébastien Messiaen, Emmanuelle Martini, Jacqueline Bernardino-Sgherri, Attila Toth, René Habert, Gabriel Livera

Publikováno v: PLoS Genetics, Vol 9, Iss 9, p e1003784 (2013)

Meiotic recombination is a mandatory process for sexual reproduction. We identified a protein specifically implicated in meiotic homologous recombination that we named: meiosis specific with OB domain (MEIOB). This protein is conserved among metazoan

Externí odkaz: https://doaj.org/article/2f8937b06c40480ba400755bdd38570d

Loss of oocytes due to conditional ablation of Murine double minute 2(Mdm2) gene is p53-dependent and results in female sterility

Autor: Rustem Uzbekov, Philippe Monget, Anne-Simone Parent, Gabriel Livera, Peggy Jarrier, Sophie Fouchécourt, Jean-Christophe Marine, Clotilde Duquenne

Publikováno v: FEBS Letters
FEBS Letters, Wiley, 2016, 590 (16), pp.2566-2574. ⟨10.1002/1873-3468.12275⟩
FEBS Letters, 2016, 590 (16), pp.2566-2574. ⟨10.1002/1873-3468.12275⟩

Murine double minute 2 and 4 (Mdm2, Mdm4) are major p53-negative regulators, preventing thus uncontrolled apoptosis induction in numerous cell types, although their function in the female germ line has received little attention. In the present work,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d8a096d18ef86ca94c180705675bf5f
https://hal.archives-ouvertes.fr/hal-01594971

Meiosis initiation in the human ovary requires intrinsic retinoic acid synthesis

Autor: R. Le Bouffant, Gabriel Livera, Virginie Rouiller-Fabre, Marie-Justine Guerquin, René Habert, Clotilde Duquenne, Nelly Frydman, Hervé Coffigny, René Frydman

Publikováno v: Human Reproduction. 25:2579-2590

BACKGROUND: The initiation of meiosis is crucial to fertility. While extensive studies in rodents have enhanced our understanding of this process, studies in human fetal ovary are lacking. METHODS: We used RT-PCR and immunohistochemistry to investiga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98dcdb5a2ccdbc09d10dbed589cdf9b8
https://doi.org/10.1093/humrep/deq195

Retinoic acid prevents germ cell mitotic arrest in mouse fetal testes

Autor: Jean-Baptiste Lahaye, Clotilde Duquenne, Marie-Justine Guerquin, René Habert, Gabriel Livera, Emilie Trautmann

Publikováno v: Cell Cycle
Cell Cycle, 2014, 7 (5), pp.656-664. ⟨10.4161/cc.7.5.5482⟩

International audience; During mouse fetal development, meiosis is initiated in female germ cells only, with male germ cells undergoing mitotic arrest. Retinoic acid (RA) is degraded by Cyp26b1 in the embryonic testis but not in the ovary where it in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e3f0132ffa1f14c6d77ed8ffb0db4c1
https://doi.org/10.4161/cc.7.5.5482

Human foetal ovary shares meiotic preventing factors with the developing testis

Autor: Alexandra Benachi, Clotilde Duquenne, Sophie Tourpin, Sébastien Messiaen, Nelly Frydman, Brahim Arkoun, Marine Poulain, Gabriel Livera, René Habert, Virginie Rouiller-Fabre

Publikováno v: Human reproduction (Oxford, England). 32(3)

Study question How can pre-meiotic germ cells persist in the human foetal ovary? Summary answer Numerous oogonia escaping meiotic entry were retrieved throughout human ovarian development simultaneously with the expression of signalling pathways prev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab74bf7c6c89ec65cbba3606dbb5f778
https://pubmed.ncbi.nlm.nih.gov/28073973