Zobrazeno 1 - 10 of 28 pro vyhledávání: '"Clotilde, Bourin"'
3
Discovery of (S)-1-((2′,6-Bis(difluoromethyl)-[2,4′-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain
Autor: Guanglin Luo, Ling Chen, Walter A. Kostich, Brian Hamman, Jason Allen, Amy Easton, Clotilde Bourin, Michael Gulianello, Jonathan Lippy, Susheel Nara, Tarun Kumar Maishal, Kamalraj Thiyagarajan, Prasadrao Jalagam, Sreenivasulu Naidu Pattipati, Kumaran Dandapani, Manoj Dokania, Pradeep Vattikundala, Vivek Sharma, Saravanan Elavazhagan, Manoj Kumar Verma, Manish Lal Das, Santosh Wagh, Anand Balakrishnan, Benjamin M. Johnson, Kenneth S. Santone, George Thalody, Rex Denton, Hariharan Saminathan, Vinay K. Holenarsipur, Anoop Kumar, Abhijith Rao, Siva Prasad Putlur, Sarat Kumar Sarvasiddhi, Ganesh Shankar, Justin V. Louis, Manjunath Ramarao, Charles M. Conway, Yu-Wen Li, Rick Pieschl, Yuan Tian, Yang Hong, Jonathan Ditta, Arvind Mathur, Jianqing Li, Daniel Smith, Joseph Pawluczyk, Dawn Sun, Shiuhang Yip, Dauh-Rurng Wu, Muthalagu Vetrichelvan, Anuradha Gupta, Alan Wilson, Suma Gopinathan, Suman Wason, Linda Bristow, Charles F. Albright, Joanne J. Bronson, John E. Macor, Carolyn D. Dzierba
Publikováno v: Journal of Medicinal Chemistry. 65:4457-4480
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::38224dcaf3d9ea2fabc4ac6df4a42a84
https://doi.org/10.1021/acs.jmedchem.1c02131
Zobrazit plný text záznamu
5
Discovery of (
Autor: Guanglin, Luo, Ling, Chen, Walter A, Kostich, Brian, Hamman, Jason, Allen, Amy, Easton, Clotilde, Bourin, Michael, Gulianello, Jonathan, Lippy, Susheel, Nara, Tarun Kumar, Maishal, Kamalraj, Thiyagarajan, Prasadrao, Jalagam, Sreenivasulu Naidu, Pattipati, Kumaran, Dandapani, Manoj, Dokania, Pradeep, Vattikundala, Vivek, Sharma, Saravanan, Elavazhagan, Manoj Kumar, Verma, Manish Lal, Das, Santosh, Wagh, Anand, Balakrishnan, Benjamin M, Johnson, Kenneth S, Santone, George, Thalody, Rex, Denton, Hariharan, Saminathan, Vinay K, Holenarsipur, Anoop, Kumar, Abhijith, Rao, Siva Prasad, Putlur, Sarat Kumar, Sarvasiddhi, Ganesh, Shankar, Justin V, Louis, Manjunath, Ramarao, Charles M, Conway, Yu-Wen, Li, Rick, Pieschl, Yuan, Tian, Yang, Hong, Jonathan, Ditta, Arvind, Mathur, Jianqing, Li, Daniel, Smith, Joseph, Pawluczyk, Dawn, Sun, Shiuhang, Yip, Dauh-Rurng, Wu, Muthalagu, Vetrichelvan, Anuradha, Gupta, Alan, Wilson, Suma, Gopinathan, Suman, Wason, Linda, Bristow, Charles F, Albright, Joanne J, Bronson, John E, Macor, Carolyn D, Dzierba
Publikováno v: Journal of medicinal chemistry. 65(6)
Recent mouse knockout studies identified adapter protein-2 associated kinase 1 (AAK1) as a viable target for treating neuropathic pain. Potent small-molecule inhibitors of AAK1 have been identified and show efficacy in various rodent pain models. (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1e41976413f9c4afd18a0630ac9bd2a0
https://pubmed.ncbi.nlm.nih.gov/35257579
Zobrazit plný text záznamu
6
757 M9657, a novel tumor-targeted conditional anti-CD137 agonist displays MSLN-dependent anti-tumor immunity
Autor: Amit Deshpande, Barroq Safi, Martina Hubensack, Lindsay Webb, Rene Schweickhardt, Natalya Belousova, Payel Ghatak, Francisca Wollerton, Joern-Peter Halle, Marat Alimzhanov, Frederic Christian Pipp, Jacques Moisan, Brain Rabinovich, Neil Brewis, Xueyuan Zhou, Andree Blaukat, Chunxiao Xu, Jose Munoz-Olaya, Clotilde Bourin, Sireesha Yalavarthi
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundThe costimulatory receptor CD137 (also known as 4-1BB and TNFRSF9) plays an important role in sustaining effective cytotoxic T cell immune responses and its agonism has been investigated as a cancer immunotherapy. In clinical trials, the sy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73aa234bc3dcbc6a5231d8e56b5ec32b
https://doaj.org/article/ac03000f810b45d7aff318ced96b4000
Zobrazit plný text záznamu
7
Abstract 593: Anti-tumor immunity and efficacy of combination treatment of M6223 and bintrafusp alfa versus the combination of M6223 and anti-PD-L1 in preclinical tumor models
Autor: Chunxiao Xu, Sireesha Yalavarthi, Clotilde Bourin, Christie Kelton, Joern-Peter Halle, Jacques Moisan
Publikováno v: Cancer Research. 82:593-593
Background: T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domains (TIGIT) is an inhibitory receptor expressed on lymphocytes and has recently emerged as a target in cancer immunotherapy. M6223 is a fully
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0da086d3b73305b7770741ed83af5105
https://doi.org/10.1158/1538-7445.am2022-593
Zobrazit plný text záznamu
8
Akademický článek
Tau overexpression impacts a neuroinflammation gene expression network perturbed in Alzheimer's disease.
Autor: Paul D Wes, Amy Easton, John Corradi, Donna M Barten, Nino Devidze, Lynn B DeCarr, Amy Truong, Aiqing He, Nestor X Barrezueta, Craig Polson, Clotilde Bourin, Marianne E Flynn, Stefanie Keenan, Regina Lidge, Jere Meredith, Joanne Natale, Sethu Sankaranarayanan, Greg W Cadelina, Charlie F Albright, Angela M Cacace
Publikováno v: PLoS ONE, Vol 9, Iss 8, p e106050 (2014)
Filamentous inclusions of the microtubule-associated protein, tau, define a variety of neurodegenerative diseases known as tauopathies, including Alzheimer's disease (AD). To better understand the role of tau-mediated effects on pathophysiology and g
Externí odkaz: https://doaj.org/article/9d297f74a7fd482c94e62f7c38c08e4e
Zobrazit plný text záznamu
10
326 The anti-TIGIT antibody M6223 induces significant anti-tumor efficacy and immune response via multiple mechanisms of action
Autor: Dong Zhang, Christie A. Kelton, Zhouxiang Chen, Clotilde Bourin, Hong Wang, Sireesha Yalavarthi, Chunxiao Xu, Lindsay Webb, Natalya Belousova, Joern-Peter Halle, Andree Blaukat, Jacques Moisan, Hui Huang, Feng Jiang
Publikováno v: Journal for ImmunoTherapy of Cancer. 9:A351-A352
BackgroundM6223 is a fully human antagonistic anti-T cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT) antibody in IgG1 format with Fc-mediated effector function.MethodsThe ability of M6223 to block the interaction of TIGIT with its li
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db370c5021d2c225a586c6b9b54221bf
https://doi.org/10.1136/jitc-2021-sitc2021.326
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje