Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Clothier, Michael F"'
Autor:
Lee, Byung H a, Dutton, Fred E a, Clothier, Michael F a, Bowman, Jerry W a, Davis, John P a, Johnson, Sandra S a, Thomas, Eileen M a, Zantello, Marjorie R a, Zinser, Erich W a, McGuire, James C b, Thompson, David P a, Geary, Timothy G a
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1999 9(12):1727-1732
Autor:
Byung H. Lee, Clothier Michael F
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:3415-3418
The dioxepinoindole ring found in marcfortine A (1) is unique among natural products. In order to determine the importance of the substitution pattern of the C24-C25 olefin, we synthesized a variety of analogs at these positions. With the exception o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2433d28563b6c07580f3106f22d42779
https://doi.org/10.1016/s0960-894x(98)00615-5
https://doi.org/10.1016/s0960-894x(98)00615-5
Publikováno v:
Tetrahedron Letters. 38:6119-6122
It has been shown that cyanogen iodide reacts with the tertiary amine ring of marcfortine A (1) to give cyano (4) and iodocyano (3) substituted products. We have now extended this reaction to various cyclic tertiary amines. © 1997 Elsevier Science L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c0af27db9a0da71e058662b74437196
https://doi.org/10.1016/s0040-4039(97)01387-7
https://doi.org/10.1016/s0040-4039(97)01387-7
Autor:
Clothier Michael F, Byung H. Lee
Publikováno v:
Tetrahedron Letters. 38:4009-4012
An improved synthesis of 14α-hydroxymarcfortine A from marcfortine A was achieved by means of a redesigned synthesis of the key intermediate [4α-hydroxy-15,16-dehydro-17-oxomarcfortine A ( 8 ).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::339f8d09574b0f9df1f64beddc61b46c
https://doi.org/10.1016/s0040-4039(97)00821-6
https://doi.org/10.1016/s0040-4039(97)00821-6
Autor:
Byung H. Lee, Clothier Michael F
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:1261-1266
The C26 dimethyl dioxepinoindole ring found in marcfortine A is unique among natural products. In order to ascertain the importance of the dimethyl moiety to anthelmintic activity, we prepared a variety of C26-dialkyl and spiroalkyl analogs. They inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92822bea78e2b6773a62db5982d97a5e
https://doi.org/10.1016/s0960-894x(97)00224-2
https://doi.org/10.1016/s0960-894x(97)00224-2
Autor:
Clothier Michael F, Byung H. Lee
Publikováno v:
The Journal of Organic Chemistry. 62:1795-1798
The paraherquamides and marcfortines represent a novel class of anthelmintics. The sole structural difference between paraherquamide A and marcfortine A occurs in ring G. We synthesized paraherquamide B from marcfortine A in six steps. Paraherquamide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cd68f44f6843c4efdbd482f3ff170e3
https://doi.org/10.1021/jo9622791
https://doi.org/10.1021/jo9622791
Autor:
Byung H. Lee, Clothier Michael F
Publikováno v:
The Journal of Organic Chemistry. 62:1863-1867
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5dbc33b52633c6b7e433e4313bc9799
https://doi.org/10.1021/jo962131h
https://doi.org/10.1021/jo962131h
Autor:
Byung H. Lee, Clothier Michael F
Publikováno v:
Tetrahedron Letters. 37:6053-6056
Treatment of Marcfortine A with various metallic oxidizing agents has led to functionalization at C12, C16, and C17. The new functional groups provide opportunities for further elaboration of this important new class of anthelmintics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c308af18a47570812071f2049b407c7
https://doi.org/10.1016/0040-4039(96)01313-5
https://doi.org/10.1016/0040-4039(96)01313-5
Autor:
Clothier Michael F, Lee Byung H
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 33:823-826
The novel [14C]-labelled 3-carbamoyl-4-hydroxycoumarins were prepared in two steps from 4-chloro-acetylsalicyloyl chloride (3). The isotope was incorporated by the reaction of diethyl malonate-1,3-14C with 4-chloro-acetylsalicyloyl chloride (3). Subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29b9f8c7049c968256a3bbbf3f921c3a
https://doi.org/10.1002/jlcr.2580330905
https://doi.org/10.1002/jlcr.2580330905
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2e0b3830863ccd05fe466283c4bfd20
https://doi.org/10.1002/chin.199134310
https://doi.org/10.1002/chin.199134310