Zobrazeno 1 - 10
of 247
pro vyhledávání: '"Closed conformation"'
Akademický článek
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Autor:
Soumya Lipsa Rath, Kishant Kumar
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Statistical and epidemiological data imply temperature sensitivity of the SARS-CoV-2 coronavirus. However, the molecular level understanding of the virus structure at different temperature is still not clear. Spike protein is the outermost structural
Externí odkaz:
https://doaj.org/article/e39a843eeeba4679a297266bfe1879a2
Autor:
Jing Li, Johannes Buchner
Publikováno v:
Biomedical Journal, Vol 36, Iss 3, Pp 106-117 (2013)
Heat shock protein 90 (Hsp90) is an ATP-dependent molecular chaperone which is essential in eukaryotes. It is required for the activation and stabilization of a wide variety of client proteins and many of them are involved in important cellular pathw
Externí odkaz:
https://doaj.org/article/a3d7e158c37446e7b56a94e9c66961e6
Publikováno v:
FEBS Open Bio, Vol 4, Iss C, Pp 915-922 (2014)
Peptidyl-tRNA hydrolase (Pth) catalyses the release of tRNA and peptide components from peptidyl-tRNA molecules. Pth from a Gram-positive bacterium Streptococcus pyogenes (SpPth) was cloned, expressed, purified and crystallised. Three-dimensional str
Externí odkaz:
https://doaj.org/article/da865ff2802147efb65d2ffef6b52088
Akademický článek
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Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
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Publikováno v:
International Journal of Biological Macromolecules. 163:200-208
Protein tyrosine phosphatase 1B (PTP1B) is a highly validated target for the treatment of type 2 diabetes and obesity. Previous studies have shown that bromophenols from marine red alga Rhodomela confervoides can inhibit PTP1B activity. However, trad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f7a331c906a96088f83344d56a79483
https://doi.org/10.1016/j.ijbiomac.2020.06.263
https://doi.org/10.1016/j.ijbiomac.2020.06.263
Autor:
Zachary Maben, Mats Larhed, Efstratios Stratikos, Lawrence J. Stern, Emmanuel N. Saridakis, Mathias Hallberg, Petros Giastas, Anastasia Mpakali
Publikováno v:
ACS Med Chem Lett
[Image: see text] Insulin-regulated aminopeptidase (IRAP) is a transmembrane zinc metallopeptidase with many important biological functions and an emerging pharmacological target. Although previous structural studies have given insight on how IRAP re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c33cd91382bbb6166397e900dce62c5c
https://doi.org/10.1021/acsmedchemlett.0c00172
https://doi.org/10.1021/acsmedchemlett.0c00172
Autor:
Yuanqing Ma, Geva Hilzenrat, Zhengmin Yang, Katharina Gaus, Elvis Pandzic, Jérémie Rossy, Daniel J. Nieves, Jesse Goyette
Publikováno v:
Biophys J
T cell receptor phosphorylation by Lck is an essential step in T cell activation. It is known that the conformational states of Lck control enzymatic activity; however, the underlying principles of how Lck finds its substrate over the plasma membrane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16b66da620e244f87ba70b5b1651e681
https://doi.org/10.1016/j.bpj.2020.01.041
https://doi.org/10.1016/j.bpj.2020.01.041
Publikováno v:
Journal of Oceanology and Limnology. 38:1891-1899
Thymidylate synthase (TS) is a key enzyme in the de novo biosynthesis of thymidine monophosphate, serving as a well-known drug target in chemotherapy against cancers and infectious diseases. Additional to its clinical value, TS is supposed to be a pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4cfe1b89c2a11d0126df5844c0ed413
https://doi.org/10.1007/s00343-019-9184-8
https://doi.org/10.1007/s00343-019-9184-8