Zobrazeno 1 - 10
of 3 591
pro vyhledávání: '"Clonal expansion"'
Publikováno v:
Genes and Environment, Vol 46, Iss 1, Pp 1-12 (2024)
Abstract Background Both mutation induction and clonal expansion of mutated cells cause cancer. The probability of cancer development depends on mutations, clonal growth rates, and carcinogenic mechanisms. A recent study showed cases of occupational
Externí odkaz:
https://doaj.org/article/34031c8157e246e3b19092f9ef835d86
Publikováno v:
Exploration of Immunology, Vol 4, Iss 4, Pp 414-432 (2024)
Aim: This article presents an investigation into various mathematical models for cell population growth, including tumor cells, and their dynamics. Methods: We classify the models into five categories: exponential, logistic, time-tested, heterogeneou
Externí odkaz:
https://doaj.org/article/13937c82c25e41c69b3e783e2319428b
Autor:
Pushpak Bhattacharjee, Miha Pakusch, Matthew Lacorcia, Chris Y. Chiu, Xin Liu, Eleonora Tresoldi, Abby Foster, Laura King, Fergus J. Cameron, Stuart I. Mannering
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Antigen-driven T-cell proliferation is often measured using fluorescent dye dilution assays, such as the CFSE-based proliferation assay. Dye dilution assays have been powerful tools to detect human CD4+ T-cell responses, particularly against autoanti
Externí odkaz:
https://doaj.org/article/dcd1140ad2bc4508954d95b6411be44b
Autor:
Ashrafali Mohamed Ismail, Evan Witt, Taren Bouwman, Wyatt Clark, Bridget Yates, Matteo Franco, Sylvia Fong
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 3, Pp 101294- (2024)
Adeno-associated virus (AAV)-based vectors are used clinically for gene transfer and persist as extrachromosomal episomes. A small fraction of vector genomes integrate into the host genome, but the theoretical risk of tumorigenesis depends on vector
Externí odkaz:
https://doaj.org/article/f3538b44edb3453095b5db1c549aaa71
Autor:
Yu, Wei-Wen 1, 20, 21, Barrett, Joy N.P. 1, 20, Tong, Jie 1, 20, Lin, Meng-Ju 1, Marohn, Meaghan 1, Devlin, Joseph C. 2, 3, Herrera, Alberto 4, Remark, Juliana 1, 3, Levine, Jamie 1, Liu, Pei-Kang 5, Fang, Victoria 6, 7, 8, 9, Zellmer, Abigail M. 10, Oldridge, Derek A. 6, 10, 11, Wherry, E. John 6, 8, 9, Lin, Jia-Ren 12, Chen, Jia-Yun 12, Sorger, Peter 12, Santagata, Sandro 12, 13, Krueger, James G. 14, Ruggles, Kelly V. 2, 15, Wang, Fei 16, 17, Su, Chang 16, 17, Koralov, Sergei B. 4, Wang, Jun 4, 18, Chiu, Ernest S. 1, Lu, Catherine P. 1, 19, 22, ∗
Publikováno v:
In Immunity 10 December 2024 57(12):2827-2842
Autor:
Fikri Abali, Richard Schasfoort, Sanne Nijland, Jelle Wittenberns, Arjan. G. J. Tibbe, Marcel den Hartog, Louis Boon, Leon W. M. M. Terstappen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Increased use of therapeutic monoclonal antibodies and the relatively high manufacturing costs fuel the need for more efficient production methods. Here we introduce a novel, fast, robust, and safe isolation platform for screening and isolat
Externí odkaz:
https://doaj.org/article/f9301016b10442f7ae97b0136080c4f1
Autor:
Lulu Yu, Vladimir Majerciak, Alexei Lobanov, Sameer Mirza, Vimla Band, Haibin Liu, Maggie Cam, Stephen H. Hughes, Douglas R. Lowy, Zhi-Ming Zheng
Publikováno v:
mBio, Vol 15, Iss 5 (2024)
ABSTRACTThe integration of HPV DNA into human chromosomes plays a pivotal role in the onset of papillomavirus-related cancers. HPV DNA integration often occurs by linearizing the viral DNA in the E1/E2 region, resulting in the loss of a critical vira
Externí odkaz:
https://doaj.org/article/c388e3f748c7460a94678b0646a8cfb1
Autor:
Laura K. Godfrey, Jan Forster, Sven-Thorsten Liffers, Christopher Schröder, Johannes Köster, Leonie Henschel, Kerstin U. Ludwig, David Lähnemann, Marija Trajkovic-Arsic, Diana Behrens, Aldo Scarpa, Rita T. Lawlor, Kathrin E. Witzke, Barbara Sitek, Steven A. Johnsen, Sven Rahmann, Bernhard Horsthemke, Michael Zeschnigk, Jens T. Siveke
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-22 (2024)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor prognosis. It is marked by extraordinary resistance to conventional therapies including chemotherapy and radiation, as well as to essentially all targeted t
Externí odkaz:
https://doaj.org/article/d600d9b4f409474cb363cc7b8d335cf3
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Ziyan Shi, Xiaofei Wang, Jiancheng Wang, Hongxi Chen, Qin Du, Yanlin Lang, Lingyao Kong, Wenqin Luo, Yuhan Qiu, Ying Zhang, Chen Li, Dingke Wen, Jie Yao, Xia Cheng, Linjun Cai, Xue Lin, Rui Wang, Zichao Mou, Shuangjie Li, Duanya Liu, Hong Zhou, Hongyu Zhou, Mu Yang
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-14 (2023)
Abstract Background Multiple sclerosis (MS) leads to demyelination and neurodegeneration with autoimmune responses in central nervous system. Patients begin with a relapsing–remitting (RR) course, and more than 80% of them may advance to secondary
Externí odkaz:
https://doaj.org/article/6096925b1cc44a0bbe44ddf55a5c55c2