Protein Expression and Codon 72 Polymorphism of TP53 Gene in Triple Negative Breast Cancer

Autor: Leandra Fiori Lopes, Roberta Losi Guembarovski, Alda Losi Guembarovski, Marina Okuyama Kishima, Clodoaldo Zago Campos, Daniela Rudgeri Derossi, Carolina Batista Ariza, Patricia Midori Murobushi Ozawa, Carlos Eduardo Coral de Oliveira, Bruna Karina Banin-Hirata, Glauco Akelinghton Freire Vitiello, Sueli Donizete Borelli, Maria Angelica Ehara Watanabe

Publikováno v: Brazilian Archives of Biology and Technology, Vol 57, Iss 6, Pp 895-899 (2014)

A subgroup of tumor that has received attention is triple-negative breast cancer (TNBC), which presents phenotype of negative estrogen receptor, negative progesterone receptor and has no overexpression of HER2. TP53 acts as a tumor suppressor limitin

Externí odkaz: https://doaj.org/article/b30f5b2e67b94ae99b8328324b479f47

Análise de polimorfismos genéticos das enzimas de metabolização GSTM1, GSTT1 e NQO1 : possíveis implicações na suscetibilidade, prognóstico e resposta terapêutica a curto prazo do câncer de mama

Autor: Clodoaldo Zago Campos

Publikováno v: Biblioteca Digital de Teses e Dissertações da UELUniversidade Estadual de LondrinaUEL.

Câncer de mama, doença incomum antes dos 35 anos, mas de incidência crescente após esta idade, é a principal neoplasia entre as mulheres no mundo. No Brasil, o Instituto Nacional do Câncer (INCA), estima para 2014 o surgimento de 57.120 novos c

Externí odkaz: http://www.bibliotecadigital.uel.br/document/?code=vtls000191501

Transforming growth factor beta receptor II (TGFBR2) promoter region polymorphism in Brazilian breast cancer patients: association with susceptibility, clinicopathological features, and interaction with TGFB1 haplotypes

Autor: Karen Brajão de Oliveira, Roberta Losi-Guembarovski, Marla Karine Amarante, Glauco Akelinghton Freire Vitiello, Bruna Karina Banin-Hirata, Maria Angelica Ehara Watanabe, Clodoaldo Zago Campos

Publikováno v: Breast Cancer Research and Treatment. 178:207-219

Transforming growth factor beta (TGFβ) has paradoxical effects in breast cancer (BC), inhibiting initial tumors while promoting aggressive ones. A polymorphism on TGFBR2 promoter region (G-875A, rs3087465) increases TGFβ type II receptor expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9194696e7961771dfd66284567d5e7c0
https://doi.org/10.1007/s10549-019-05370-1

Transforming growth factor beta 1 (TGFβ1) polymorphisms and haplotype structures have dual roles in breast cancer pathogenesis

Autor: Maria Angelica Ehara Watanabe, Clodoaldo Zago Campos, Glauco Akelinghton Freire Vitiello, Guilherme Cesar Martelossi Cebinelli, Roberta Losi Guembarovski, Marla Karine Amarante, Karen Brajão de Oliveira, Carlos Eduardo Coral de Oliveira, Bruna Karina Banin Hirata, Alda Losi Guembarovski

Publikováno v: Journal of Cancer Research and Clinical Oncology. 144:645-655

Despite the documented dual role of TGFβ1 in breast cancer (BC) pathogenesis, the subtype-specific influences of its polymorphisms remain undocumented. The present study investigated the effects of the TGFB1 promoter region (rs1800468 or G-800A and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ae512c6ee873fc633a8b2a8908e8b4
https://doi.org/10.1007/s00432-018-2585-9

Concordance Analysis of ALK Gene Fusion Detection Methods in Patients with Non-Small-Cell Lung Cancer from Chile, Brazil, and Peru

Autor: Gonzalo Sepúlveda-Hermosilla, Matías Freire, Alejandro Blanco, Javier Cáceres, Rodrigo Lizana, Liliana Ramos, Rodrigo Assar Cuevas, Diego Ampuero, Osvaldo Aren, Sara Chernilo, María L. Spencer, Giuliano Bernal, Jacqueline Flores, Germán Rasse, Carolina Sánchez, Katherine Marcelain, Solange Rivas, Gabriela P. Branco, María Galli de Amorim, Diana N. Nunes, Emmanuel Dias-Neto, Helano C. Freitas, Cristina Fernández, Paola Pérez, Ricardo Armisén, Luiz Araujo, Luis Pires, Nils Skare, Gustavo Girotto, Manuela Zereu, Helano Freitas, Hakaru Tadokoro, Ana Caroline Gelatti, Jose Fernando Moura, Clarissa Mathias, Pedro Rafael De Marchi, Fernando Silva, Mayler Olombrada Nunes de Santos, Marianna Deway Andrade Dracoulakis, Renata Pinho Costa, Luciana Castro, Paulo Guilherme de Oliveira Salles, Clodoaldo Zago Campos, Maria Andrade Livia, Osvaldo Arén Frontera, Eduardo Yanez Ruiz, Monica Ahumada Olea, Loreto Spencer, Alejandro Ortega Vasquez, German Rasse, Juan Bertoglio, Jose David Zorrilla Silvera, Hernan Moron Escobar, Luis Riva Gonzalez, Luis Alberto Mas Lopez, José Luis Fernando Hurtado De Mendoza Acurio, Giovanna Victoria Abrill Mendoza, Alfredo Aguilar, Gerardo Campos Siccha, Ricardo Sanchez Sevillano, Sylvia Chandía, Pablo Araos, Ana Mejías, Francisca Angulo, Jessica Troncoso, David Jara, Marcela Astete, María Jesús Galleguillos, Helano Carioca Freitas, Diana Noronha Nunes, Gabriela Branco, Marina Eloi, Melissa Pizzi, Jordana Silva, Thais F. Bartelli, Jessica Toro, Luciana Oliveira-Cruz, Daniela Diez

Publikováno v: The Journal of molecular diagnostics : JMD. 23(9)

About 4% to 7% of the non–small-cell lung cancer patients have anaplastic lymphoma kinase (ALK) rearrangements, and specific targeted therapies improve patients' outcomes significantly. ALK gene fusions are detected by immunohistochemistry or fluor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a8b21a25b5a16472f51facac5bc122
https://pubmed.ncbi.nlm.nih.gov/34186175