Výsledky vyhledávání - "Clodia Osipo"

Akademický článek

The effect of an exopolysaccharide probiotic molecule from Bacillus subtilis on breast cancer cells

Autor: Mai R. Nguyen, Emily Ma, Debra Wyatt, Katherine L. Knight, Clodia Osipo

Publikováno v: Frontiers in Oncology, Vol 13 (2023)

IntroductionMany well-known risk factors for breast cancer are associated with dysbiosis (an aberrant microbiome). However, how bacterial products modulate cancer are poorly understood. In this study, we investigated the effect of an exopolysaccharid

Externí odkaz: https://doaj.org/article/a8ed490ebc1746b2845e2c786134e72d

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Abstract P3-11-01: Increasing DAXX Expression in ER+ Breast Cancer Cells to Overcome Endocrine Therapy Resistance

Autor: Clodia Osipo, Kathy S. Albain, Daniel Peiffer, Debra Wyatt

Publikováno v: Cancer Research. 83:P3-11

Background: New treatment paradigms are needed to overcome resistance to endocrine therapy (ET; tamoxifen or aromatase inhibitors, AI) in ER+ breast cancer (BC). ET resistance is due to survival of breast cancer stem cells (BCSCs) that contribute to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0fb42787d18be4ee62601deb94db1916
https://doi.org/10.1158/1538-7445.sabcs22-p3-11-01

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2 Supplementary Tables and 8 Supplementary Figures with Legends from Deubiquitinase OTUD6B Isoforms Are Important Regulators of Growth and Proliferation

Autor: Maurizio Bocchetta, Clodia Osipo, Vijayalakshmi Ananthanarayanan, Megan J. Weber, Sara Alani, Caroline Askonas, Anna Sobol

Table ST1. List of oligonucleotides and siRNAs used in this study. Table ST2. List of antibodies used in this study. Figure S1. Sequence alignment of OTUD6A and OTUD6B (isoform 1) performed using Clustal omega software. Figure S2. RNA silencing to OT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced2f842a48e25a77c25e6d760ef995a
https://doi.org/10.1158/1541-7786.22510750

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Data from Deubiquitinase OTUD6B Isoforms Are Important Regulators of Growth and Proliferation

Autor: Maurizio Bocchetta, Clodia Osipo, Vijayalakshmi Ananthanarayanan, Megan J. Weber, Sara Alani, Caroline Askonas, Anna Sobol

Deubiquitinases (DUB) are increasingly linked to the regulation of fundamental processes in normal and cancer cells, including DNA replication and repair, programmed cell death, and oncogenes and tumor suppressor signaling. Here, evidence is presente

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75ea945406ad6cf41d53005b81b32724
https://doi.org/10.1158/1541-7786.c.6539719

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Abstract P1-08-22: The role of DAXX as a critical growth regulator of triple negative breast cancer

Autor: Clodia Osipo, Debra Wyatt, Michelle Fernandez, Daniel S Peiffer, Kathy S Albain

Publikováno v: Cancer Research. 82:P1-08

Background: Triple negative breast cancer (TNBC) is a heterogeneous disease that frequently presents at a metastatic stage or upon initial early stage diagnosis, and may recur quickly. Treatment options are limited outside of cytotoxic chemotherapy i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6119f0d447b8dd63df12af52e83012fc
https://doi.org/10.1158/1538-7445.sabcs21-p1-08-22

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Abstract P5-12-10: A commensal’s exopolysaccharide inhibits breast cancer proliferation in vitro but promotes tumor growth in vivo

Autor: Mai Rachel Nguyen, Katherine L Knight, Clodia Osipo

Publikováno v: Cancer Research. 82:P5-12

Background: Recent decades have started to realize the importance of the microbiome in cancer initiation, progression and response to therapy. Recent findings suggest that both the local and distal microbiome may influence tumor growth. Although many

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85d555514fa69701db5a4abaf9cb5908
https://doi.org/10.1158/1538-7445.sabcs21-p5-12-10

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Table S2 from Inhibition of HER2 Increases JAGGED1-dependent Breast Cancer Stem Cells: Role for Membrane JAGGED1

Autor: Clodia Osipo, Lucio Miele, Alexandra Filipovic, Andrew Green, Emad Rakha, Michelle Fernandez, Daniel S. Peiffer, Patricia Simms, Andrew T. Baker, Debra Wyatt, Deep Shah

Case processing summary (upper tables) and overall comparisons (lower tables) for the tissue microarray (TMA) analysis performed on 145 primary, stage II-III, HER2+ breast cancer tissues. Statistics was performed using Log Rank (Mantel-Cox test).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::128d19039893b6d86cd169520ea02a2b
https://doi.org/10.1158/1078-0432.22464417

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Data from DAXX Suppresses Tumor-Initiating Cells in Estrogen Receptor–Positive Breast Cancer Following Endocrine Therapy

Autor: Clodia Osipo, Kathy S. Albain, Andrew K. Dingwall, Jeffrey Ng, Ali Piracha, Andrei Zlobin, Debra Wyatt, Daniel S. Peiffer

Estrogen receptor (ER)-positive breast cancer recurrence is thought to be driven by tumor-initiating cells (TIC). TICs are enriched by endocrine therapy through NOTCH signaling. Side effects have limited clinical trial testing of NOTCH-targeted thera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a3e6a081da63e2549986c34c25de2f9
https://doi.org/10.1158/0008-5472.c.6511124.v1

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