Zobrazeno 1 - 10
of 3 858
pro vyhledávání: '"Clock gene"'
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-22 (2024)
Abstract Background Temporomandibular joint osteoarthritis (TMJOA) has a high incidence rate, but its pathogenesis remains unclear. Circadian rhythm is an important oscillation in the human body and influences various biological activities. However,
Externí odkaz:
https://doaj.org/article/846f6d9c1cf34e2ea8fd3bcc514db8bf
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-19 (2024)
Abstract Background The androgen receptor (AR) is a drug target used to inhibit AR and prostate cancer (PCa) growth. Surprisingly, treatment with supraphysiological androgen level (SAL), used in bipolar androgen therapy, inhibits growth of PCa sugges
Externí odkaz:
https://doaj.org/article/1a795d9f667a48d68b5166f2f0ec8f96
Publikováno v:
Progress in Fishery Sciences, Vol 45, Iss 3, Pp 101-116 (2024)
Clock genes play a pivotal role in the rhythm maturation of bony fish ovaries. To explore the role of clock genes in the rhythmic ovarian development and maturation of tongue sole (Cynoglossus semilaevis), we used real-time fluorescent quantitative P
Externí odkaz:
https://doaj.org/article/ccd6fc9dd6ce4ce9a50f625ca3684659
Publikováno v:
Jichu yixue yu linchuang, Vol 44, Iss 2, Pp 231-234 (2024)
Objective To investigate whether discontinuous sleep supplementation can reduce myocardial ischemia-reperfusion injury in diabetic rats aggravated by circadian rhythm disorder. Methods The rats were injected intra-peritoneal with 1% streptozotocin(ST
Externí odkaz:
https://doaj.org/article/52a609534be946b3b2f07c308ad8f530
Autor:
Stevenson, Tyler John, author
Publikováno v:
On Rheostasis : The Hierarchical Organization of Physiological Stability, 2023, ill.
Externí odkaz:
https://doi.org/10.1093/oso/9780197665572.003.0003
Publikováno v:
Heliyon, Vol 10, Iss 10, Pp e30708- (2024)
Objectives: Vascular diseases are often caused by the interaction between macrophages and vascular smooth muscle cells (VSMCs). This study aims to elucidate whether chronotherapy with rosiglitazone (RSG) can regulate the secretion rhythm of macrophag
Externí odkaz:
https://doaj.org/article/3dcb4f3c91b34421b46d83ba6bcde5bd
Publikováno v:
Nutrients, Vol 16, Iss 14, p 2263 (2024)
Circadian rhythm plays an important role in intestinal homeostasis and intestinal immune function. Circadian rhythm dysregulation was reported to induce intestinal microbiota dysbiosis, intestinal barrier disruption, and trigger intestinal inflammati
Externí odkaz:
https://doaj.org/article/c5599564edfd4d089030f50733581464
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7458 (2024)
Circadian rhythms regulate physiological processes in approximately 24 h cycles, and their disruption is associated with various diseases. Inflammation may perturb circadian rhythms, though these interactions remain unclear. This study examined wheth
Externí odkaz:
https://doaj.org/article/d48c2c6c82084475b580a0dc287b4c6a
Autor:
Xiaojun Wang, Xuanqi Liu, Qiushuang Gao, Xuchao Gu, Guannan Zhang, Zhiyuan Sheng, Tao Wu, Zheling Su, Wenhao Wang, Maoqing Ye
Publikováno v:
Chinese Medicine, Vol 18, Iss 1, Pp 1-16 (2023)
Abstract Background The Gegen Qinlian Decoction (GGQLD) is a renowned traditional Chinese medicinal formula that has been used for centuries to effectively treat asymptomatic Hyperuricemia (HUA). This study aims to investigate the underlying mechanis
Externí odkaz:
https://doaj.org/article/749f8f1d6fb14e95bd6c91a5d632cbd0
Autor:
Margherita Tassan Mazzocco, Claudia Pisanu, Luigi Russo, Clementina Acconcia, Marco Cambiaghi, Sofia De Girolamo, Alessio Squassina, Laura Cherchi, Elena Monzani, Francesca Scebba, Debora Angeloni, Danilo De Gregorio, Sofia Nasini, Stefano Dall’Acqua, Stefania Sut, Federico Suprani, Mario Garzilli, Beatrice Guiso, Vittoria Pulcinelli, Maria Novella Iaselli, Ilaria Pinna, Giulia Somaini, Laura Arru, Carolina Corrias, Pasquale Paribello, Federica Pinna, Gabriella Gobbi, Flavia Valtorta, Bernardo Carpiniello, Mirko Manchia, Stefano Comai
Publikováno v:
Pharmacological Research, Vol 198, Iss , Pp 106993- (2023)
The treatment of bipolar disorder (BD) still remains a challenge. Melatonin (MLT), acting through its two receptors MT1 and MT2, plays a key role in regulating circadian rhythms which are dysfunctional in BD. Using a translational approach, we examin
Externí odkaz:
https://doaj.org/article/2266cc8d3b0c4df090ca73432daa27fa