Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Clive Yik Sham Chung"'
Autor:
Sze Keong Tey, Samuel Wan Ki Wong, Cherlie Lot Sum Yeung, Jason Ying Ki Li, Xiaowen Mao, Clive Yik Sham Chung, Judy Wai Ping Yam
Publikováno v:
Journal of Extracellular Biology, Vol 1, Iss 5, Pp n/a-n/a (2022)
Abstract MET receptor tyrosine kinase is a cell surface receptor that plays important role in embryonic development and tissue regeneration. Aberrant MET activation has been widely reported in different human cancers, making MET an attractive therape
Externí odkaz:
https://doaj.org/article/a64727e9f234401ea2558fbfa61591a7
Autor:
Xiaowen Mao, Sze Keong Tey, Cherlie Lot Sum Yeung, Ernest Man Lok Kwong, Yi Man Eva Fung, Clive Yik Sham Chung, Lung‐Yi Mak, Danny Ka Ho Wong, Man‐Fung Yuen, James Chung Man Ho, Herbert Pang, Maria Pik Wong, Carmen Oi‐Ning Leung, Terence Kin Wah Lee, Victor Ma, William Chi‐Shing Cho, Peihua Cao, Xiaoping Xu, Yi Gao, Judy Wai Ping Yam
Publikováno v:
Advanced Science, Vol 7, Iss 21, Pp n/a-n/a (2020)
Abstract In hepatocellular carcinoma (HCC) patients with extrahepatic metastasis, the lung is the most frequent site of metastasis. However, how the lung microenvironment favors disseminated cells remains unclear. Here, it is found that nidogen 1 (NI
Externí odkaz:
https://doaj.org/article/b579b31386644f0d93cd314e5ed657ce
Autor:
Abdullah Husain, Yung-Tuen Chiu, Karen Man-Fong Sze, Daniel Wai-Hung Ho, Yu-Man Tsui, Eliana Mary Senires Suarez, Vanilla Xin Zhang, Lo-Kong Chan, Eva Lee, Joyce Man-Fong Lee, Tan-To Cheung, Carmen Chak-Lui Wong, Clive Yik-Sham Chung, Irene Oi-Lin Ng
Publikováno v:
Journal of Hepatology. 77:383-396
The highly proliferative nature of hepatocellular carcinoma (HCC) frequently results in a hypoxic intratumoural microenvironment, which creates a therapeutic challenge owing to a lack of mechanistic understanding of the phenomenon. We aimed to identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc150c3be83a1e8d8b1a5670db6c538e
https://doi.org/10.1016/j.jhep.2022.02.018
https://doi.org/10.1016/j.jhep.2022.02.018
Publikováno v:
Nat Protoc
Nature protocols, vol 17, iss 7
Nature protocols, vol 17, iss 7
Hydrogen peroxide (H(2)O(2)) is a key member of the reactive oxygen species family of transient small molecules that has broad contributions to oxidative stress and redox signaling. The development of selective and sensitive chemical probes can enabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30c66976a077f505c9d8a56f5894e09d
https://doi.org/10.1038/s41596-022-00694-7
https://doi.org/10.1038/s41596-022-00694-7
We report a new class of compounds, N-acryloylindole-alkynes (NAIAs), as promising cysteine-reactive probes for proteome-wide cysteine profiling and imaging of thiol oxidative modifications. NAIAs showed superior cysteine reactivity owing to delocali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12602f4ca9b8ec69e3657ea9301d8d4c
https://doi.org/10.26434/chemrxiv-2022-khww5
https://doi.org/10.26434/chemrxiv-2022-khww5
Autor:
Clive Yik-Sham Chung, Pei Liu, Kevin J. Bruemmer, Evan W. Miller, Christopher J. Chang, Kaoru Saijo, Yuki Nishikawa, Sumin Lee, Itaru Hamachi, Laura Craciun
Publikováno v:
Journal of the American Chemical Society, vol 142, iss 35
J Am Chem Soc
J Am Chem Soc
Copper is a required nutrient for life and particularly important to the brain and central nervous system. Indeed, copper redox activity is essential to maintaining normal physiological responses spanning neural signaling to metabolism, but at the sa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cad14cdb2dd12d99665d869e65c01c4
https://doi.org/10.1021/jacs.0c05727
https://doi.org/10.1021/jacs.0c05727
Autor:
Zuo Hang Yu, Fung Kit Tang, Thomas Hin Fung Wong, Ho Yu Au-Yeung, Hajime Hirao, Clive Yik-Sham Chung
Publikováno v:
ChemPlusChem. 85:653-658
Fluorescein-derived superoxide probes featuring a copper(II) complex that can be activated by superoxide to initiate ether bond cleavage and uncage a fluorescein reporter for imaging in live cells are described. Compared to other superoxide sensing m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b53fda699284a6d05ff5bcc9068c8f
https://doi.org/10.1002/cplu.202000059
https://doi.org/10.1002/cplu.202000059
Autor:
Donita C. Brady, Tiffany Tsang, Jessica M. Posimo, Christopher J. Chang, Julianne M. Davis, Sumin Lee, Clive Yik-Sham Chung
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 37
Copper is essential for life, and beyond its well-established ability to serve as a tightly-bound, redox-active active site cofactor for enzyme function, emerging data suggest that cellular copper also exists in labile pools, defined as loosely bound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe9873a0915d94a21e973419f7cbeebf
https://doi.org/10.1073/pnas.1904610116
https://doi.org/10.1073/pnas.1904610116
Autor:
Carl C. Ward, James A. Olzmann, Roberto Zoncu, Charles A. Berdan, Hijai R. Shin, Clive Yik-Sham Chung, Daniel K. Nomura, Breanna Ford
Publikováno v:
Nature chemical biology, vol 15, iss 8
Nature chemical biology
Nature chemical biology
Autophagy is a lysosomal degradation pathway that eliminates aggregated proteins and damaged organelles to maintain cellular homeostasis. A major route for activating autophagy involves inhibition of the mTORC1 kinase, but current mTORC1-targeting co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99fb22331151eb9f8df7a9c7b23a8e0c
https://doi.org/10.1038/s41589-019-0308-4
https://doi.org/10.1038/s41589-019-0308-4
Autor:
Herbert Pang, Man-Fung Yuen, Xiaowen Mao, Ernest Man Lok Kwong, William C. Cho, Sze Keong Tey, Yi Gao, Maria Pik Wong, Cherlie Lot Sum Yeung, Judy Wai Ping Yam, Victor W.S. Ma, Yi Man Eva Fung, Carmen Oi Ning Leung, Xiaoping Xu, James Chung-Man Ho, Lung-Yi Mak, Terence Kin Wah Lee, Peihua Cao, Clive Yik-Sham Chung, Danny Ka-Ho Wong
Publikováno v:
Advanced Science
Advanced Science, Vol 7, Iss 21, Pp n/a-n/a (2020)
Advanced Science, Vol 7, Iss 21, Pp n/a-n/a (2020)
In hepatocellular carcinoma (HCC) patients with extrahepatic metastasis, the lung is the most frequent site of metastasis. However, how the lung microenvironment favors disseminated cells remains unclear. Here, it is found that nidogen 1 (NID1) in me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::908f4317b9c183bbfe19a68ed1c099a8
https://pubmed.ncbi.nlm.nih.gov/33173740
https://pubmed.ncbi.nlm.nih.gov/33173740