Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Clive Wilson"'
Autor:
John D. Mason, Ewan Marks, Shih‐Jung Fan, Kristie McCormick, Clive Wilson, Adrian L. Harris, Freddie C. Hamdy, Chris Cunningham, Deborah C. I. Goberdhan
Publikováno v:
Journal of Extracellular Vesicles, Vol 13, Iss 6, Pp n/a-n/a (2024)
Abstract Exosomes are secreted vesicles made intracellularly in the endosomal system. We have previously shown that exosomes are not only made in late endosomes, but also in recycling endosomes marked by the monomeric G‐protein Rab11a. These vesicl
Externí odkaz:
https://doaj.org/article/7e95800ddaf04b45a7772cc3e250af9b
Autor:
Adam Wells, Cláudia C Mendes, Felix Castellanos, Phoebe Mountain, Tia Wright, S Mark Wainwright, M Irina Stefana, Adrian L Harris, Deborah C I Goberdhan, Clive Wilson
Publikováno v:
PLoS Genetics, Vol 19, Iss 10, p e1010979 (2023)
Secretory cells in glands and the nervous system frequently package and store proteins destined for regulated secretion in dense-core granules (DCGs), which disperse when released from the cell surface. Despite the relevance of this dynamic process t
Externí odkaz:
https://doaj.org/article/3a0376c416114f0cba80597cd7bc3c26
Autor:
Aashika Sekar, Aaron Leiblich, S Mark Wainwright, Cláudia C Mendes, Dhruv Sarma, Josephine E E U Hellberg, Carina Gandy, Deborah C I Goberdhan, Freddie C Hamdy, Clive Wilson
Publikováno v:
PLoS Genetics, Vol 19, Iss 6, p e1010815 (2023)
In prostate cancer, loss of the tumour suppressor gene, Retinoblastoma (Rb), and consequent activation of transcription factor E2F1 typically occurs at a late-stage of tumour progression. It appears to regulate a switch to an androgen-independent for
Externí odkaz:
https://doaj.org/article/bba9b34ae61a425293f1b4d2428048d7
Autor:
Pauline P. Marie, Shih‐Jung Fan, John Mason, Adam Wells, Cláudia C. Mendes, S. Mark Wainwright, Sheherezade Scott, Roman Fischer, Adrian L. Harris, Clive Wilson, Deborah C. I. Goberdhan
Publikováno v:
Journal of Extracellular Vesicles, Vol 12, Iss 3, Pp n/a-n/a (2023)
Abstract Exosomes are secreted nanovesicles with potent signalling activity that are initially formed as intraluminal vesicles (ILVs) in late Rab7‐positive multivesicular endosomes, and also in recycling Rab11a‐positive endosomes, particularly un
Externí odkaz:
https://doaj.org/article/50b2356af6a840a7a39fb67b07019c8c
Autor:
Ghulam Hassan Dar, Cláudia C. Mendes, Wei-Li Kuan, Alfina A. Speciale, Mariana Conceição, André Görgens, Inna Uliyakina, Miguel J. Lobo, Wooi F. Lim, Samir EL Andaloussi, Imre Mäger, Thomas C. Roberts, Roger A. Barker, Deborah C. I. Goberdhan, Clive Wilson, Matthew J. A. Wood
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
GAPDH is generally considered a housekeeping gene and functions in glycolysis. Here, the authors show that GAPDH has a role in promoting vesicle clustering in endosomes and can load siRNA onto the surface of extracellular vesicles, which can be explo
Externí odkaz:
https://doaj.org/article/b286aa9a491c4fbfb8a3ac8161e8f868
Autor:
Luca Cassetta, Pedro Rodrigues, Toni Andreu, Bruno Botta, Sven Brandau, Chrissie Brierley, Clive Wilson, Inga Dadeshidze, Lucia Forzi, Federica Ortelli, Mafalda Quintas
Publikováno v:
Research Ideas and Outcomes, Vol 6, Iss , Pp 1-15 (2020)
Cancer has been for many years the second leading cause of mortality right after cardiovascular diseases, representing 25% of all the deaths reported yearly and this tendency is expected to increase. Although the recent public health emergency caused
Externí odkaz:
https://doaj.org/article/90e7161754c7411d8286d87b2c5eca7c
Autor:
Derek M R Nye, Richard M Albertson, Alexis T Weiner, J Ian Hertzler, Matthew Shorey, Deborah C I Goberdhan, Clive Wilson, Kevin A Janes, Melissa M Rolls
Publikováno v:
PLoS Biology, Vol 18, Iss 3, p e3000657 (2020)
While many regulators of axon regeneration have been identified, very little is known about mechanisms that allow dendrites to regenerate after injury. Using a Drosophila model of dendrite regeneration, we performed a candidate screen of receptor tyr
Externí odkaz:
https://doaj.org/article/f335bd2fb73341978ccd9bb1deec833d
Autor:
Ghulam Hassan Dar, Cláudia C. Mendes, Wei-Li Kuan, Alfina A. Speciale, Mariana Conceição, André Görgens, Inna Uliyakina, Miguel J. Lobo, Wooi F. Lim, Samir EL Andaloussi, Imre Mäger, Thomas C. Roberts, Roger A. Barker, Deborah C. I. Goberdhan, Clive Wilson, Matthew J. A. Wood
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/cd863df03b094f24b93fa9ac4d906638
Publikováno v:
Biology Open, Vol 6, Iss 5, Pp 563-570 (2017)
Insulin and insulin-like growth factor signalling (IIS), which is primarily mediated by the PI3-kinase (PI3K)/PTEN/Akt kinase signalling cassette, is a highly evolutionarily conserved pathway involved in co-ordinating growth, development, ageing and
Externí odkaz:
https://doaj.org/article/39f2af9c7a2945868faea83c36d275e4
Autor:
Aaron Leiblich, Josephine E E U Hellberg, Aashika Sekar, Carina Gandy, Claudia C Mendes, Siamak Redhai, John Mason, Mark Wainwright, Pauline Marie, Deborah C I Goberdhan, Freddie C Hamdy, Clive Wilson
Publikováno v:
PLoS Biology, Vol 17, Iss 10, p e3000145 (2019)
Male reproductive glands like the mammalian prostate and the paired Drosophila melanogaster accessory glands secrete seminal fluid components that enhance fecundity. In humans, the prostate, stimulated by environmentally regulated endocrine and local
Externí odkaz:
https://doaj.org/article/d282914d9b1345bcb8a8f49206fdf220