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pro vyhledávání: '"Clive Sweet"'
Autor:
Clive Sweet
Publikováno v:
Access Microbiology
Studies with a murine cytomegalovirus mutant tsm5 suggested two possible approaches to producing a live attenuated human cytomegalovirus vaccine. One approach would be to use a combination of five to six mutants where an attenuating mutation in the g
Autor:
Abdulaziz Al-Ali, Clive Sweet
Publikováno v:
Journal of Medical Virology. 88:1613-1621
A mutation (C890Y) introduced into the M70 primase gene of murine cytomegalovirus (MCMV) resulted in reduced viral replication in murine embryo fibroblasts at 40°C and the mutant was severely attenuated in vivo. The attenuated replication of the M70
Publikováno v:
Journal of Medical Virology. 85:1968-1974
Cytomegalovirus (CMV) is a widely prevalent herpesvirus that is well tolerated by an immune competent host yet establishes a state of chronic infection. The virus is thought to undergo frequent subclinical episodes of reactivation which leads to an u
Publikováno v:
Journal of Medical Virology. 84:912-922
A mutant of murine cytomegalovirus (MCMV), tsm5, which is temperature-sensitive for replication in murine embryo fibroblasts at 40°C, failed to replicate to detectable levels in mice. A total of 18 non-synonymous mutations have been identified in ts
Publikováno v:
The Journal of Adhesion. 86:1029-1040
At present there are few methods available for observing the adhesion of viruses. Also, it is difficult to determine virus concentrations on-line. This paper describes the “NanoSight,” a microscope instrument which counts nanoparticles directly f
Publikováno v:
Journal of Chemical Technology & Biotechnology. 85:1223-1228
BACKGROUND: The surge of studies on artificial and natural nanoparticles has revealed a new world for engineering and life sciences, but in most instances, the small scale has made their number-concentration determination in liquids a challenging pro
Autor:
Graham Anderson, Vasileios Bekiaris, Peter J. L. Lane, David R. Withers, Mi-Yeon Kim, Clive Sweet, Fabrina Gaspal
Publikováno v:
European Journal of Immunology. 39:2120-2125
Prior to acquiring a memory phenotype, antigen-activated CD8(+) T cells need to expand and then undergo a contraction phase. Utilizing two different antigenic stimuli, we provide evidence that the tumor necrosis factor receptors OX40 and CD30 integra
Publikováno v:
Journal of Medical Virology
Identification of mutations in mutants derived chemically is a difficult and relatively random process. NimbleGen Comparative Genome Sequencing (CGS) was assessed as an inexpensive, rapid method of identifying mutations in the temperature‐sensitive
Publikováno v:
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. 7:59-70
Influenza virus is a major human pathogen that causes epidemics and pandemics with increased morbidity and, especially in the elderly and those with pre-existing medical conditions, increased mortality. Currently avian influenza viruses are causing d
Publikováno v:
Journal of Medical Virology. 80:1233-1242
A viable virus could not be recovered from a mutant murine cytomegalovirus (MCMV) BAC in which the M34 ORF had been deleted (BACDeltaM34). In contrast, an M34 mutant virus (RcM34), in which the M34 ORF was interrupted by transposon insertion at nt 44