Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Clive S. McKimmie"'
Autor:
Lorna Hayden, Tiia Semenoff, Verena Schultz, Simon F. Merz, Katie J. Chapple, Moses Rodriguez, Arthur E. Warrington, Xiaohong Shi, Clive S. McKimmie, Julia M. Edgar, Katja Thümmler, Chris Linington, Marieke Pingen
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-16 (2020)
Abstract Progressive multi-focal leukoencephalopathy (PML) is a potentially fatal encephalitis caused by JC polyomavirus (JCV). PML principally affects people with a compromised immune system, such as patients with multiple sclerosis (MS) receiving t
Externí odkaz:
https://doaj.org/article/134b9017783e48d094d6013af6dc4be8
Autor:
Emma Brown, Gemma Swinscoe, Daniella A Lefteri, Ravi Singh, Amy Moran, Rebecca F Thompson, Daniel Maskell, Hannah Beaumont, Matthew J Bentham, Claire Donald, Alain Kohl, Andrew Macdonald, Neil Ranson, Richard Foster, Clive S McKimmie, Antreas C Kalli, Stephen Griffin
Publikováno v:
eLife, Vol 13 (2024)
Flaviviruses, including Zika virus (ZIKV), are a significant global health concern, yet no licensed antivirals exist to treat disease. The small membrane (M) protein plays well-defined roles during viral egress and remains within virion membranes fol
Externí odkaz:
https://doaj.org/article/2ea2a660429141029618f43cf5ee6d6c
Autor:
Claire Scott, Jayakanth Kankanala, Toshana L Foster, Daniel H Goldhill, Peng Bao, Katie Simmons, Marieke Pingen, Matthew Bentham, Elizabeth Atkins, Eleni Loundras, Ruth Elderfield, Jolyon K Claridge, Joseph Thompson, Peter R Stilwell, Ranjitha Tathineni, Clive S McKimmie, Paul Targett-Adams, Jason R Schnell, Graham P Cook, Stephen Evans, Wendy S Barclay, Richard Foster, Stephen Griffin
Publikováno v:
PLoS Pathogens, Vol 16, Iss 8, p e1008716 (2020)
Pandemic influenza A virus (IAV) remains a significant threat to global health. Preparedness relies primarily upon a single class of neuraminidase (NA) targeted antivirals, against which resistance is steadily growing. The M2 proton channel is an alt
Externí odkaz:
https://doaj.org/article/b1c9af88e0784e2fbf40273c4f74c8fe
Autor:
Christopher. W. Wasson, Eva. M. Clavane, Rebecca. L. Ross, Gemma Migneco, Cristina Antinozzi, Jane. M. Y. Brown, Luigi Di Luigi, Clive. S. McKimmie, Francesco Del Galdo, Paul. J. Meakin
BackgroundThe beta-amyloid precursor protein cleaving enzyme 1 (BACE1) is well known for its role in the development of Alzheimer’s disease via the generation of β-amyloid. Recent publications, including our own, have demonstrated a role for this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65c1f79584eb3b2ec24beeb008fbb637
https://doi.org/10.1101/2022.12.22.521579
https://doi.org/10.1101/2022.12.22.521579
Autor:
Daniella A. Lefteri, Steven R. Bryden, Marieke Pingen, Sandra Terry, Ailish McCafferty, Emily F. Beswick, Georgi Georgiev, Marleen Van der Laan, Valeria Mastrullo, Paola Campagnolo, Robert M. Waterhouse, Margus Varjak, Andres Merits, Rennos Fragkoudis, Stephen Griffin, Kave Shams, Emilie Pondeville, Clive S. McKimmie
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 24, pp. e2114309119
Viruses transmitted by Aedes mosquitoes are an increasingly important global cause of disease. Defining common determinants of host susceptibility to this large group of heterogenous pathogens is key for informing the rational design of panviral medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b791903ad8f28ff5ffa919132885371
https://serval.unil.ch/resource/serval:BIB_141ADBB062C5.P001/REF.pdf
https://serval.unil.ch/resource/serval:BIB_141ADBB062C5.P001/REF.pdf
Autor:
Christopher W. Wasson, Jörg H W Distler, Clarissa Corinaldesi, Rebecca L. Ross, Agne Antanaviciute, Clive S. McKimmie, Francesco Del Galdo, Yasser M. El-Sherbiny, Steve Holmes, Antonio Carriero, Ian M. Carr, Gemma Migneco
Publikováno v:
Annals of the Rheumatic Diseases
ObjectivesPlasmacytoid dendritic cells (pDC) have been implicated in the pathogenesis of autoimmune diseases, such as scleroderma (SSc). However, this has been derived from indirect evidence using ex vivo human samples or mouse pDC in vivo. We have d
Autor:
Clive S. McKimmie, Antreas C. Kalli, Griffin Sc, Alain Kohl, Rebecca F. Thompson, Matthew Bentham, Neil A. Ranson, Richard Foster, Andrew Macdonald, Gemma Swinscoe, D.P. Maskell, Beaumont H, Andres Merits, Singh R, Daniella A. Lefteri, Emma Brown, Claire L. Donald
Flaviviruses, including Zika virus (ZIKV), are a significant global health concern, yet no licensed antivirals exist to treat disease. The small M (Membrane) protein plays well-defined roles during viral egress, yet remains within virion membranes fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3cc356cc04297908b5106fb6c6a138f
https://doi.org/10.1101/2021.03.11.435022
https://doi.org/10.1101/2021.03.11.435022
Autor:
Rennos Fragkoudis, Andres Merits, Steven R. Bryden, Daniella A. Lefteri, Georgi Georgiev, Paola Campagnolo, Emilie Pondeville, Margus Varjak, Kave Shams, Robert M. Waterhouse, Emily F Beswick, Stephen Griffin, Sandra Terry, Marleen Van der Laan, Valeria Mastrullo, Marieke Pingen, Clive S. McKimmie
SummaryViruses transmitted byAedesmosquitoes constitute an increasingly important global health burden. Defining common determinants of host susceptibility to this large group of heterogenous pathogens are key for informing the rational design of new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22fa4c62aac4672c6d93df599baf9ac8
https://doi.org/10.1101/2021.02.19.431961
https://doi.org/10.1101/2021.02.19.431961
Autor:
Place S, Stephen J. Richards, Peter Hillmen, Claire E McKinley, Clive S. McKimmie, Richard D. Parker, Baretto Rl, Darren J. Newton, Dalal S, Stephen Griffin, Graham P. Cook, Leach R, Kathryn Riley, Talha Munir, Payne Dj, Louise Arnold
Advancing age and chronic health conditions, significant risk factors for severe COVID-19, are associated with a pro-inflammatory state, termed inflamm-aging. CXCR6+T cells are known to traffic to the lung and have been reported to increase with age.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f558f2dfcee134bfcccf00f50c4d3d8a
https://doi.org/10.1101/2021.01.25.428125
https://doi.org/10.1101/2021.01.25.428125
Autor:
Marieke Pingen, Katie J. Chapple, Tiia Semenoff, Clive S. McKimmie, Lorna Hayden, Christopher Linington, Arthur E. Warrington, Xiaohong Shi, Julia M. Edgar, Verena Schultz, Moses Rodriguez, Katja Thümmler, Simon F. Merz
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-16 (2020)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
Progressive multi-focal leukoencephalopathy (PML) is a potentially fatal encephalitis caused by JC polyomavirus (JCV). PML principally affects people with a compromised immune system, such as patients with multiple sclerosis (MS) receiving treatment