Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Clive S. D'SANTOS"'
Autor:
Benedetto DiCiaccio, Marco Seehawer, Zheqi Li, Andriana Patmanidis, Triet Bui, Pierre Foidart, Jun Nishida, Clive S. D’Santos, Evangelia K. Papachristou, Malvina Papanastasiou, Andrew H. Reiter, Xintao Qiu, Rong Li, Yijia Jiang, Xiao-Yun Huang, Anton Simeonov, Stephen C. Kales, Ganesha Rai, Madhu Lal-Nag, Ajit Jadhav, Myles Brown, Jason S. Carroll, Henry W. Long, Kornelia Polyak
Publikováno v:
Cell Reports, Vol 43, Iss 12, Pp 114991- (2024)
Summary: We previously described that the KDM5B histone H3 lysine 4 demethylase is an oncogene in estrogen-receptor-positive breast cancer. Here, we report that KDM5A is amplified and overexpressed in basal breast tumors, and KDM5 inhibition (KDM5i)
Externí odkaz:
https://doaj.org/article/d86443eea36b447cb9cbe10e44a6827f
Autor:
Leila Hosseinzadeh, Zoya Kikhtyak, Geraldine Laven-Law, Stephen M. Pederson, Caroline G. Puiu, Clive S. D’Santos, Elgene Lim, Jason S. Carroll, Wayne D. Tilley, Amy R. Dwyer, Theresa E. Hickey
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-28 (2024)
Abstract Background The androgen receptor (AR) is a tumor suppressor in estrogen receptor (ER) positive breast cancer, a role sustained in some ER negative breast cancers. Key factors dictating AR genomic activity in a breast context are largely unkn
Externí odkaz:
https://doaj.org/article/d7b51d564a0b4733aace68da8648cf13
Autor:
Danish Memon, Michael B. Gill, Evangelia K. Papachristou, David Ochoa, Clive S. D’Santos, Martin L. Miller, Pedro Beltrao
Publikováno v:
Cell Reports, Vol 35, Iss 7, Pp 109155- (2021)
Summary: Somatic DNA copy number variations (CNVs) are prevalent in cancer and can drive cancer progression, albeit with often uncharacterized roles in altering cell signaling states. Here, we integrate genomic and proteomic data for 5,598 tumor samp
Externí odkaz:
https://doaj.org/article/bcd6d8570bcd420384dd5f5b566fa10a
Autor:
Evangelia K. Papachristou, Kamal Kishore, Andrew N. Holding, Kate Harvey, Theodoros I. Roumeliotis, Chandra Sekhar Reddy Chilamakuri, Soleilmane Omarjee, Kee Ming Chia, Alex Swarbrick, Elgene Lim, Florian Markowetz, Matthew Eldridge, Rasmus Siersbaek, Clive S. D’Santos, Jason S. Carroll
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Chromatin-associated protein complexes play a critical role in the regulation of gene expression in health and disease. Here, the authors describe a sensitive mass spectrometry-based method to monitor the dynamic interactions of endogenous chromatin-
Externí odkaz:
https://doaj.org/article/6d77c38577f14fe9922378d351669816
Autor:
Charles G. Mullighan, Kathryn G. Roberts, Clive S. D'Santos, Evangelia K. Papachristou, Gang Wu, Beisi Xu, Laura J. Janke, Yunchao Chang, Emily A. Backhaus, Hiroki Yoshihara, Zhaohui Gu, Ilaria Iacobucci, Qingsong Gao, Chunxu Qu, Kirsten M. Dickerson
Supplementary Data from ZNF384 Fusion Oncoproteins Drive Lineage Aberrancy in Acute Leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d296a1585dea01389f577a8557e2afb
https://doi.org/10.1158/2643-3230.22544664.v1
https://doi.org/10.1158/2643-3230.22544664.v1
Autor:
Lisa Drew, Stephen E. Fawell, Michael Zinda, David M. Weinstock, Raphael Koch, Jamal C. Saeh, Wenlin Shao, Clive S. D'Santos, Chandra Sekhar Reddy Chilamakuri, Valar Nila Roamio Franklin, Nancy Su, Petar Pop-Damkov, Maryann San Martin, Steven W. Criscione, Douglas Ferguson, Theresa Proia, Scott Boiko, Justin Cidado
Intermittent dosing of AZD4573 drives regression of hematological tumor xenografts as predicted by a PK/PD/efficacy model.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4089f363c0de6f76d589e6db02857ef6
https://doi.org/10.1158/1078-0432.22473198.v1
https://doi.org/10.1158/1078-0432.22473198.v1
Autor:
Lisa Drew, Stephen E. Fawell, Michael Zinda, David M. Weinstock, Raphael Koch, Jamal C. Saeh, Wenlin Shao, Clive S. D'Santos, Chandra Sekhar Reddy Chilamakuri, Valar Nila Roamio Franklin, Nancy Su, Petar Pop-Damkov, Maryann San Martin, Steven W. Criscione, Douglas Ferguson, Theresa Proia, Scott Boiko, Justin Cidado
List of antibodies (S1), PK/PD/efficacy model parameters (S2), putative cancer-associated genes (S3), and transcripts modulated by AZD4573 (S4).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c9d91db0a50ac30baa8045d2a585387
https://doi.org/10.1158/1078-0432.22473189.v1
https://doi.org/10.1158/1078-0432.22473189.v1
Autor:
Lisa Drew, Stephen E. Fawell, Michael Zinda, David M. Weinstock, Raphael Koch, Jamal C. Saeh, Wenlin Shao, Clive S. D'Santos, Chandra Sekhar Reddy Chilamakuri, Valar Nila Roamio Franklin, Nancy Su, Petar Pop-Damkov, Maryann San Martin, Steven W. Criscione, Douglas Ferguson, Theresa Proia, Scott Boiko, Justin Cidado
Purpose:Cyclin-dependent kinase 9 (CDK9) is a transcriptional regulator and potential therapeutic target for many cancers. Multiple nonselective CDK9 inhibitors have progressed clinically but were limited by a narrow therapeutic window. This work des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e78a2f9d8bc4116c23d641a6d2430c69
https://doi.org/10.1158/1078-0432.c.6528438
https://doi.org/10.1158/1078-0432.c.6528438
Autor:
Kornelia Polyak, Jason S. Carroll, Carlos Caldas, Andrew H. Beck, Oscar M. Rueda, Clive S. D'Santos, Andriy Marusyk, Ying Su, Katherine Murphy, Evangelia K. Papachristou, Chandra Sekhar Reddy Chilamakuri, Anne Trinh, Francisco Beca, Laura E. Stevens, Felipe Flores, Bojana Jovanović, Natalie Kingston, Nicholas W. Harper, Ashim Subedee, Guillermo Peluffo
Supplementary Figure S1. Transcription factors enriched in TNBC. Supplementary Figure S2. EN1 is a dependency in TNBC cell lines. Supplementary Figure S3. Transcriptional and genomic targets of EN1 in TNBC cells. Supplementary Figure S4. The effect o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::658c98b4219b2e3179638ae9f9eefb09
https://doi.org/10.1158/0008-5472.22422632.v1
https://doi.org/10.1158/0008-5472.22422632.v1
Autor:
Lisa Drew, Stephen E. Fawell, Michael Zinda, David M. Weinstock, Raphael Koch, Jamal C. Saeh, Wenlin Shao, Clive S. D'Santos, Chandra Sekhar Reddy Chilamakuri, Valar Nila Roamio Franklin, Nancy Su, Petar Pop-Damkov, Maryann San Martin, Steven W. Criscione, Douglas Ferguson, Theresa Proia, Scott Boiko, Justin Cidado
Material, methods, supplementary references, and list of supplementary tables.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::452c2d4f2e72a9f64fb946ec7fddeb69
https://doi.org/10.1158/1078-0432.22473192
https://doi.org/10.1158/1078-0432.22473192