Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Clive R, Pullinger"'
Autor:
Jelena Mustra Rakic, Clive R. Pullinger, Erin L. Van Blarigan, Irina Movsesyan, Eveline Oestreicher Stock, Mary J. Malloy, John P. Kane
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 24 (2023)
Background African American smokers have 2.5 times higher risk for stroke compared with nonsmokers (higher than other races). About 50% of the African American population carry 1 or 2 genetic variants (G1 and G2; rare in other races) of the apolipopr
Externí odkaz:
https://doaj.org/article/7634921acbe8489abb6382cf06a176d5
Autor:
Mark Terrelonge, Sara C. LaHue, Christopher Tang, Irina Movsesyan, Clive R. Pullinger, Dena B. Dubal, Jacqueline Leung, Vanja C. Douglas
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-6 (2022)
Abstract Despite the association between cognitive impairment and delirium, little is known about whether genetic differences that confer cognitive resilience also confer resistance to delirium. To investigate whether older adults without postoperati
Externí odkaz:
https://doaj.org/article/058ec36c04b548ac886a0f33a8448677
Autor:
Weilai Dong, Karen H.Y. Wong, Youbin Liu, Michal Levy-Sakin, Wei-Chien Hung, Mo Li, Boyang Li, Sheng Chih Jin, Jungmin Choi, Francesc Lopez-Giraldez, Dedeepya Vaka, Annie Poon, Catherine Chu, Richard Lao, Melek Balamir, Irina Movsesyan, Mary J. Malloy, Hongyu Zhao, Pui-Yan Kwok, John P. Kane, Richard P. Lifton, Clive R. Pullinger
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 6, Pp 100209- (2022)
Low levels of high density lipoprotein-cholesterol (HDL-C) are associated with an elevated risk of arteriosclerotic coronary heart disease. Heritability of HDL-C levels is high. In this research discovery study, we used whole-exome sequencing to iden
Externí odkaz:
https://doaj.org/article/9009d5614d1843c1a294988f08875cf9
Autor:
Grace Marie Jones, Russell Caccavello, Sergiu P. Palii, Clive R. Pullinger, John P. Kane, Kathleen Mulligan, Alejandro Gugliucci, Jean-Marc Schwarz
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 3, Pp 455-463 (2020)
Elevated levels of triglyceride-rich lipoproteins (TRLs), both fasting and postprandial, are associated with increased risk for atherosclerosis. However, guidelines for treatment are defined solely by fasting lipid levels, even though postprandial li
Externí odkaz:
https://doaj.org/article/9db46222ea3b45a89912dd109e562aee
Autor:
Jacqueline S. Dron, Jian Wang, Adam D. McIntyre, Henian Cao, John F. Robinson, P. Barton Duell, Priya Manjoo, James Feng, Irina Movsesyan, Mary J. Malloy, Clive R. Pullinger, John P. Kane, Robert A. Hegele
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 11, Pp 1953-1958 (2019)
Severe hypertriglyceridemia (HTG) is a relatively common form of dyslipidemia with a complex pathophysiology and serious health complications. HTG can develop in the presence of rare genetic factors disrupting genes involved in the triglyceride (TG)
Externí odkaz:
https://doaj.org/article/cdf329801bed4b7895839adade6cadb7
Autor:
Clive R. Pullinger, Patricia M. O’Connor, Josefina M. Naya‐Vigne, Steven T. Kunitake, Irina Movsesyan, Philip H. Frost, Mary J. Malloy, John P. Kane
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 7 (2021)
Background We previously showed that levels of prebeta‐1 high‐density lipoprotein (HDL), the principal acceptor of cholesterol effluxed from cells, including artery wall macrophages, are positively associated with coronary heart disease (CHD) and
Externí odkaz:
https://doaj.org/article/4bd5053424c64daf88adf626a6d457d9
Autor:
Karen H.Y. Wong, Michal Levy‐Sakin, Walfred Ma, Nina Gonzaludo, Angel C.Y. Mak, Dedeepya Vaka, Annie Poon, Catherine Chu, Richard Lao, Melek Balamir, Zoe Grenville, Nicolas Wong, John P. Kane, Pui‐Yan Kwok, Mary J. Malloy, Clive R. Pullinger
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 7, Iss 12, Pp n/a-n/a (2019)
Abstract Background Homozygous Familial Hypercholesterolemia (HoFH) is an inherited recessive condition associated with extremely high levels of low‐density lipoprotein (LDL) cholesterol in affected individuals. It is usually caused by homozygous o
Externí odkaz:
https://doaj.org/article/d6dd132b586144a49db854b61fbb6e01
Autor:
Jelena Mustra Rakic, Clive R. Pullinger, Erin L. Van Blarigan, Irina Movsesyan, Eveline Oestreicher Stock, Mary J. Malloy, John P. Kane
Publikováno v:
medRxiv
IntroductionAmong African Americans, tobacco smokers have 2.5 times higher risk for stroke compared to non-smokers; the tobacco-related stroke risk being higher than in other races/ethnicities. About one half of African Americans carry at least one o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::290785c5cabf892915ad6df83a6d01ce
https://doi.org/10.1101/2023.04.28.23289292
https://doi.org/10.1101/2023.04.28.23289292
Autor:
Henian Cao, Jacqueline S. Dron, Robert A. Hegele, John P. Kane, Adam D. McIntyre, Praneet K. Gill, Clive R. Pullinger, Allison A Dilliott, Mary J. Malloy, Irina G. Movsesyan, Jian Wang
Publikováno v:
Journal of Clinical Lipidology. 15:88-96
Susceptibility to severe hypertriglyceridemia (HTG), defined as plasma triglyceride (TG) levels ≥10 mmol/L (880 mg/dL), is conferred by both heterozygous rare variants in five genes involved in TG metabolism and numerous common single-nucleotide po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25e706aed83b98a1d796d801d93d8ec5
https://doi.org/10.1016/j.jacl.2020.11.007
https://doi.org/10.1016/j.jacl.2020.11.007
Autor:
Henian Cao, Arden Lawson, John P. Kane, Robert A. Hegele, Adam D. McIntyre, Irina Movsesyan, Mary J. Malloy, Brent D. Davis, Allison A Dilliott, Clive R. Pullinger, Jacqueline S. Dron, Jian Wang
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 40:1935-1941
Objective: Genetic determinants of severe hypertriglyceridemia include both common variants with small effects (assessed using polygenic risk scores) plus heterozygous and homozygous rare variants in canonical genes directly affecting triglyceride me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76b1b878743aab483985b60a4c68f8a4
https://doi.org/10.1161/atvbaha.120.314168
https://doi.org/10.1161/atvbaha.120.314168