Výsledky vyhledávání - "Clive P Morgan"

Akademický článek

Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt)

Autor: Timothy Erickson, Clive P Morgan, Jennifer Olt, Katherine Hardy, Elisabeth Busch-Nentwich, Reo Maeda, Rachel Clemens, Jocelyn F Krey, Alex Nechiporuk, Peter G Barr-Gillespie, Walter Marcotti, Teresa Nicolson

Publikováno v: eLife, Vol 6 (2017)

Transmembrane O-methyltransferase (TOMT/LRTOMT) is responsible for non-syndromic deafness DFNB63. However, the specific defects that lead to hearing loss have not been described. Using a zebrafish model of DFNB63, we show that the auditory and vestib

Externí odkaz: https://doaj.org/article/8c67b3aa4fc342c1bcf127fb9e97b312

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Akademický článek

PDZD7-MYO7A complex identified in enriched stereocilia membranes

Autor: Clive P Morgan, Jocelyn F Krey, M'hamed Grati, Bo Zhao, Shannon Fallen, Abhiraami Kannan-Sundhari, Xue Zhong Liu, Dongseok Choi, Ulrich Müller, Peter G Barr-Gillespie

Publikováno v: eLife, Vol 5 (2016)

While more than 70 genes have been linked to deafness, most of which are expressed in mechanosensory hair cells of the inner ear, a challenge has been to link these genes into molecular pathways. One example is Myo7a (myosin VIIA), in which deafness

Externí odkaz: https://doaj.org/article/3e65b5e5353b40bf98ff63ca95741554

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Heterodimeric capping protein is required for stereocilia length and width regulation

Autor: Jocelyn F. Krey, Connor B. Benson, Deborah I. Scheffer, David P. Corey, Sarath Vijayakumar, Rachel A. Dumont, Christopher L. Cunningham, Matthew R. Avenarius, Sherri M. Jones, Peter G. Barr-Gillespie, Clive P Morgan, Ulrich Müller

Publikováno v: The Journal of Cell Biology

The authors show that the heterodimeric capping protein subunit CAPZB is required during development of stereocilia, actin-filled processes of the inner ear. They find that CAPZB prevents depolymerization of newly formed actin filaments during the de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae9df068ab825104c6bbc15885878e21
http://europepmc.org/articles/PMC5674897

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TRPV6, TRPM6 and TRPM7 Do Not Contribute to Hair-Cell Mechanotransduction

Autor: Ulrich Müller, Anthony J. Ricci, Bifeng Pan, Peter G. Barr-Gillespie, Clive P Morgan, Michael Bateschell, Wei Xiong, Piotr Kazmierczak, Meredith LeMasurier, Matthew R. Avenarius, Ruby Larisch, Hongyu Zhao

Publikováno v: Frontiers in Cellular Neuroscience, Vol 12 (2018)
Frontiers in Cellular Neuroscience

Hair cells of the inner ear transduce mechanical stimuli like sound or head movements into electrical signals, which are propagated to the central nervous system. The hair-cell mechanotransduction channel remains unidentified. We tested whether three

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d024774b8d190ba13e583cd567910cea
http://journal.frontiersin.org/article/10.3389/fncel.2018.00041/full

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TRPV5, TRPV6, TRPM6, and TRPM7 do not contribute to hair-cell mechanotransduction

Autor: Peter G. Barr-Gillespie, Clive P Morgan, Ruby Larisch, Ulrich Mueller, Meredith LeMasurier, Anthony J. Ricci, Hongyu Zhao, Bifeng Pan, Wei Xiong, Matthew R. Avenarius, Michael Bateschell

The hair-cell mechanotransduction channel remains unidentified. We tested whether four transient receptor channel (TRP) family members, TRPV5, TRPV6, TRPM6, and TRPM7, participated in transduction. Using cysteine-substitution mouse knock-ins and meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd92ab29c6a0e7e8c197295afc52484d
https://doi.org/10.1101/204172

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Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt)

Autor: Jocelyn F. Krey, Katherine Hardy, Peter G. Barr-Gillespie, Clive P Morgan, Teresa Nicolson, Walter Marcotti, Reo Maeda, Rachel Clemens, Timothy B. Erickson, Jennifer Olt, Alex Nechiporuk, Elisabeth M. Busch-Nentwich

Publikováno v: eLife, Vol 6 (2017)
eLife

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f62517a4a3e48fed184a58bb26b30ec3
https://www.repository.cam.ac.uk/handle/1810/277291

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PDZD7-MYO7A complex identified in enriched stereocilia membranes

Autor: Peter G. Barr-Gillespie, Clive P Morgan, Jocelyn F. Krey, Abhiraami Kannan-Sundhari, Bo Zhao, Dongseok Choi, M'hamed Grati, Ulrich Müller, Shannon Fallen, Xue Zhong Liu

Publikováno v: eLife
eLife, Vol 5 (2016)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a884c04e82425afa066ec5226184c4c
http://europepmc.org/articles/PMC5005036

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Regulation of PI3K signalling by the phosphatidylinositol transfer protein PITPα during axonal extension in hippocampal neurons

Autor: Carl Hobbs, Michiel T. van Diepen, Britta J. Eickholt, Michelle Li, Shamshad Cockcroft, Patrick Doherty, Victoria Allen-Baume, Sadaf Shadan, Katharina E. Cosker, Clive P. Morgan

Publikováno v: Journal of Cell Science. 121:796-803

Phosphatidylinositol transfer proteins (PITPs) mediate the transfer of phosphatidylinositol (PtdIns) or phosphatidylcholine (PtdCho) between two membrane compartments, thereby regulating the interface between signalling, phosphoinositide (PI) metabol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e793aa4b2872e9efe617af57e288cf
https://doi.org/10.1242/jcs.019166

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