Zobrazeno 1 - 10 of 29 pro vyhledávání: '"Clive G, Ballard"'
1
Akademický článek
Dementia with Lewy Bodies Drug Therapies in Clinical Trials: Systematic Review up to 2022
Autor: Carla Abdelnour, Maria Camila Gonzalez, Lucy L. Gibson, Kathleen L. Poston, Clive G. Ballard, Jeffrey L. Cummings, Dag Aarsland
Publikováno v: Neurology and Therapy, Vol 12, Iss 3, Pp 727-749 (2023)
Abstract Introduction Reviews of randomized clinical trials (RCTs) in dementia with Lewy bodies (DLB) are essential for informing ongoing research efforts of symptomatic therapies and potentially disease-modifying therapies (DMTs). Methods We perform
Externí odkaz: https://doaj.org/article/1098fd9019dd4ba8a04039d27687ce28
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2
Akademický článek
Patterns of Mitochondrial TSPO Binding in Cerebral Small Vessel Disease: An in vivo PET Study With Neuropathological Comparison
Autor: Paul Wright, Mattia Veronese, Ndabezinhle Mazibuko, Federico E. Turkheimer, Eugenii A. Rabiner, Clive G. Ballard, Steven C. R. Williams, Avinash Kumar Hari Narayanan, Bahiya Osrah, Ricky Williams, Tiago R. Marques, Oliver D. Howes, Federico Roncaroli, Michael J. O'Sullivan
Publikováno v: Frontiers in Neurology, Vol 11 (2020)
Small vessel disease (SVD) is associated with cognitive impairment in older age and be implicated in vascular dementia. Post-mortem studies show proliferation of activated microglia in the affected white matter. However, the role of inflammation in S
Externí odkaz: https://doaj.org/article/29e9fbcaf5e44f6bb48a11cbfb8b5dc5
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3
Akademický článek
Ras-ERK-ETS inhibition alleviates neuronal mitochondrial dysfunction by reprogramming mitochondrial retrograde signaling.
Autor: Olivia F Duncan, Lucy Granat, Ramya Ranganathan, Vandana K Singh, David Mazaud, Manolis Fanto, David Chambers, Clive G Ballard, Joseph M Bateman
Publikováno v: PLoS Genetics, Vol 14, Iss 7, p e1007567 (2018)
Mitochondrial dysfunction activates the mitochondrial retrograde signaling pathway, resulting in large scale changes in gene expression. Mitochondrial retrograde signaling in neurons is poorly understood and whether retrograde signaling contributes t
Externí odkaz: https://doaj.org/article/6f4f0cf8245141e7b83e7200ec2da95e
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