Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Clive Da Costa"'
Autor:
Wenhui Zhu, Weifen Li, Jian Jiang, Dilong Wang, Xinliang Mao, Jin Zhang, Xunzhi Zhang, Jinlong Chang, Peijia Yao, Xiuyan Yang, Clive Da Costa, Ying Zhang, Jiezhong Yu, Huiliang Li, Shupeng Li, Xinjin Chi, Ningning Li
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Depression is a common recurrent psychiatric disorder with a high lifetime prevalence and suicide rate. At present, although several traditional clinical drugs such as fluoxetine and ketamine, are widely used, medications with a high efficiency and r
Externí odkaz:
https://doaj.org/article/19c48917f81e41e6a01af424ee77399b
Autor:
E Josue Ruiz, Adan Pinto-Fernandez, Andrew P Turnbull, Linxiang Lan, Thomas M Charlton, Hannah C Scott, Andreas Damianou, George Vere, Eva M Riising, Clive Da Costa, Wojciech W Krajewski, David Guerin, Jeffrey D Kearns, Stephanos Ioannidis, Marie Katz, Crystal McKinnon, Jonathan O'Connell, Natalia Moncaut, Ian Rosewell, Emma Nye, Neil Jones, Claire Heride, Malte Gersch, Min Wu, Christopher J Dinsmore, Tim R Hammonds, Sunkyu Kim, David Komander, Sylvie Urbe, Michael J Clague, Benedikt M Kessler, Axel Behrens
Publikováno v:
eLife, Vol 10 (2021)
Lung squamous cell carcinoma (LSCC) is a considerable global health burden, with an incidence of over 600,000 cases per year. Treatment options are limited, and patient’s 5-year survival rate is less than 5%. The ubiquitin-specific protease 28 (USP
Externí odkaz:
https://doaj.org/article/eeea231092ca40e880a44f8ed5d20d8d
Autor:
E. Josue Ruiz, Linxiang Lan, Markus Elmar Diefenbacher, Eva Madi Riising, Clive Da Costa, Atanu Chakraborty, Joerg D. Hoeck, Bradley Spencer-Dene, Gavin Kelly, Jean-Pierre David, Emma Nye, Julian Downward, Axel Behrens
Publikováno v:
JCI Insight, Vol 6, Iss 13 (2021)
The AP-1 transcription factor c-Jun is required for Ras-driven tumorigenesis in many tissues and is considered as a classical proto-oncogene. To determine the requirement for c-Jun in a mouse model of K-RasG12D–induced lung adenocarcinoma, we induc
Externí odkaz:
https://doaj.org/article/d1bdf75630574d7b9e1c28b13a237cf7
Gremlin-1 Promotes Colorectal Cancer Cell Metastasis by Activating ATF6 and Inhibiting ATF4 Pathways
Autor:
Ruohan Li, Huaixiang Zhou, Mingzhe Li, Qiuyan Mai, Zhang Fu, Youheng Jiang, Changxue Li, Yunfei Gao, Yunping Fan, Kaiming Wu, Clive Da Costa, Xia Sheng, Yulong He, Ningning Li
Publikováno v:
Cells, Vol 11, Iss 14, p 2136 (2022)
Cancer cell survival, function and fate strongly depend on endoplasmic reticulum (ER) proteostasis. Although previous studies have implicated the ER stress signaling network in all stages of cancer development, its role in cancer metastasis remains t
Externí odkaz:
https://doaj.org/article/51b43ba691da42dc8603de8f3f034e00
Autor:
Xianan Fu, Shoupeng Wei, Tao Wang, Hengxin Fan, Ying Zhang, Clive Da Costa, Sebastian Brandner, Guang Yang, Yihang Pan, Yulong He, Ningning Li
Publikováno v:
Cells, Vol 11, Iss 8, p 1334 (2022)
G-protein-coupled receptors (GPCRs) remain one of the most successful targets for therapeutic drugs approved by the US Food and Drug Administration (FDA). Many novel orphan GPCRs have been identified by human genome sequencing and considered as putat
Externí odkaz:
https://doaj.org/article/17d2f3b12d1e4596a56853faaccebb14
Autor:
Tao Wang, Yunxia Zhou, Yunping Fan, Hao Duan, Xiaoyu Guo, Jinlong Chang, Youheng Jiang, Changxue Li, Zhang Fu, Yunfei Gao, Xiaoran Guo, Kastytis Sidlauskas, Zhenqiang He, Clive Da Costa, Xia Sheng, Dinglan Wu, Jinqiu Yuan, Huiliang Li, Yulong He, Yonggao Mou, Ningning Li
Publikováno v:
Advanced Science.
Autor:
Dilong Wang, Wenhui Zhu, Yihang Pan, Tao Wang, Youheng Jiang, Liyang Liang, Shilu Fan, Hui Yan, Clive Da Costa, Xuesong Zhang, Huiliang Li, Yulong He, Ningning Li
Background: Accumulating clinical evidence demonstrated that gut microbiota (GM) transfer substantially ameliorated autistic symptoms, implying a role of GM in autism spectrum disorder (ASD). Continuous investigation reported GM alteration in ASD ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84cbd2fc5956e28576832db32693791a
https://doi.org/10.21203/rs.3.rs-1505710/v1
https://doi.org/10.21203/rs.3.rs-1505710/v1
Publikováno v:
Day 2 Tue, November 16, 2021.
While Floating Offshore Wind (FOW) represents a significant opportunity to foster wind energy development and to contribute to remarkable CO2 emissions reductions, its associated operational costs are still substantially above grid parity, and signif
Autor:
Axel Behrens, Clive Da Costa, Min Wu, David Joseph Guerin, Emma Nye, Jonathan O'Connell, Adan Pinto-Fernandez, Eva M. Riising, Jeffrey D Kearns, Tim Hammonds, Andrew P. Turnbull, Crystal McKinnon, E. Josue Ruiz, Claire Heride, Christopher J. Dinsmore, Malte Gersch, Ian Rosewell, Thomas M. Charlton, Linxiang Lan, Neil P. Jones, Andreas Damianou, Hannah C. Scott, Benedikt M. Kessler, Sylvie Urbé, Michael J. Clague, Natalia Moncaut, Wojciech W. Krajewski, Stephanos Ioannidis, David Komander, Marie Katz, Sunkyu Kim, George Vere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::205d91672bd258cadd1c178b2544807d
https://doi.org/10.7554/elife.71596.sa2
https://doi.org/10.7554/elife.71596.sa2
Autor:
Malte Gersch, Thomas M. Charlton, Michael J. Clague, Linxiang Lan, Hannah C. Scott, Sylvie Urbé, George Vere, Min Wu, Sunkyu Kim, Stephanos Ioannidis, Claire Heride, Jeffrey D Kearns, Jonathan O'Connell, David Komander, Adan Pinto-Fernandez, E. Josue Ruiz, Emma Nye, Axel Behrens, Benedikt M. Kessler, Andrew P. Turnbull, Marie Katz, Natalia Moncaut, Andreas Damianou, Wojciech W. Krajewski, Neil P. Jones, Christopher J. Dinsmore, Ian Rosewell, Tim Hammonds, David Joseph Guerin, Eva M. Riising, Crystal McKinnon, Clive Da Costa
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Lung squamous cell carcinoma (LSCC) is a considerable global health burden, with an incidence of over 600,000 cases per year. Treatment options are limited, and patient’s 5-year survival rate is less than 5%. The ubiquitin-specific protease 28 (USP