Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Cliona P MacSweeney"'
Autor:
Lindsay Gibson, David R. Barn, Mark Craighead, William Arbuckle, Rachel Milne, Hazel Sloan, Chris Claxton, Susan Elizabeth Napier, Matilda Bingham, Grant Wishart, Cliona P MacSweeney, Richard Goodwin, N.G. Irving, Zara Turnbull, Kirsteen Buchanan, Jeremy Presland, Angus R. Brown, Alan Byford, Chris Mort, Fiona Thomson, Susan Goutcher, James R. Baker, Lee Fielding, Trevor Young
The discovery of a novel series of 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamide antagonists of the vasopressin V(1A) receptor is disclosed. Compounds 47 and 48 were found to be high affinity, selective vasopressin V(1A) antagonists.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dc0d41bbebfcb82e69bfeb8a58ca72c
https://doi.org/10.1016/j.bmcl.2011.02.096
https://doi.org/10.1016/j.bmcl.2011.02.096
Autor:
Jack Pick, Mark Craighead, Heather A. Zanetakos, Jeffrey J. Letourneau, Rachel Milne, Hema Desai, Leigh Campbell-Wan, Jeremy Presland, Michael Ohlmeyer, James R. Baker, Nasrin Ansari, Ray Jui-Hsiang Chan, Cliona P MacSweeney, Douglas S. Auld, Maria L. Webb, Jiuqiao Zhao, Chris Riviello, J. Richard Morphy, Stuart A. Best, Irina Neagu, Susan Elizabeth Napier, Koc-Kan Ho
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:3813-3817
Synthesis and structure–activity relationships (SAR) of a novel series of vasopressin V1b antagonists are described. 2-(6-Aminomethylaryl-2-aryl-4-oxo-quinazolin-3(4H)-yl)acetamide have been identified with low nanomolar affinity for the V1b recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::644306305bb4a232c2c9422c904af22d
https://doi.org/10.1016/j.bmcl.2011.04.022
https://doi.org/10.1016/j.bmcl.2011.04.022
Autor:
Francesca Spiga, Mark Craighead, Louise R Harrison, Fiona Thomson, Stafford L. Lightman, Cliona P MacSweeney
Publikováno v:
Journal of Endocrinology. 200:285-291
Exposure to chronic restraint (CR) modifies the hypothalamic–pituitary–adrenal (HPA) axis response to subsequent acute stressors with adaptation of the response to a homotypic and sensitization of the response to a heterotypic stressor. Since vas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0208c5f86c02a481ef3c453a62075be
https://doi.org/10.1677/joe-08-0425
https://doi.org/10.1677/joe-08-0425
Autor:
Fiona Thomson, Stafford L. Lightman, Cliona P MacSweeney, SA Wood, Louise R Harrison, DM Knight, Mark Craighead, Francesca Spiga
Publikováno v:
Journal of Endocrinology. 200:273-283
Vasopressin (AVP), produced in parvocellular neurons of the hypothalamic paraventricular nucleus, regulates, together with CRH, pituitary ACTH secretion. The pituitary actions of AVP are mediated through the G protein receptor V1b (V1b|R). In man, hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f198fc9e4bbcf11256a245e73a9eedb
https://doi.org/10.1677/joe-08-0421
https://doi.org/10.1677/joe-08-0421
Autor:
Morag Grassie, Fiona Thomson, Stafford L. Lightman, SA Wood, Louise R Harrison, Cliona P MacSweeney, Mark Craighead, Francesca Spiga
Publikováno v:
University of Bristol-PURE
We investigated the effect of the glucocorticoid receptor (GR) antagonist Org 34850 on fast and delayed inhibition of corticosterone secretion in response to the synthetic glucocorticoid methylprednisolone (MPL). Male rats were implanted with a cathe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::581b30c14986c3bc927230b49da9cdf3
https://doi.org/10.1677/joe-07-0503
https://doi.org/10.1677/joe-07-0503
Autor:
Jiuqiao Zhao, Gé S.F. Ruigt, J. Richard Morphy, Mark Craighead, Maria L. Webb, Susan Elizabeth Napier, Chris Riviello, Jeffrey J. Letourneau, Irina Neagu, Rachel Milne, Ard Peeters, Heather A. Zanetakos, Michael Ohlmeyer, Fiona Thomson, Koc-Kan Ho, Leigh Campbell-Wan, Cliona P MacSweeney, Katharine A. Goan, Douglas S. Auld, Jeremy Presland, Stuart A. Best, Jui-Hsiang Chan, Nasrin Ansari, James R. Baker, Ellen G.J. Hulskotte, Hema Desai
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(6)
Synthesis and structure-activity relationships (SAR) of a novel series of vasopressin V(1b) (V(3)) antagonists are described. 2-(4-Oxo-2-aryl-quinazolin-3(4H)-yl)acetamides have been identified with low nanomolar affinity for the V(1b) receptor and g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a649bc2a59fc110b6f0e0bf28067ca98
https://pubmed.ncbi.nlm.nih.gov/21353540
https://pubmed.ncbi.nlm.nih.gov/21353540
Autor:
Mark Craighead, Susanne K. Droste, YM Kershaw, Fiona Thomson, Becky L. Conway-Campbell, Stafford L. Lightman, Francesca Spiga, Bernard W. M. M. Peeters, DM Knight, Cliona P MacSweeney
The effects of RU486 and S-P, a more selective glucocorticoid receptor antagonist from Schering-Plough, were investigated on glucocorticoid receptor nuclear translocation and DNA binding. In the in vitro study, AtT20 cells were treated with vehicle o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e031875fe3f2eba80eede431fd561d1
https://europepmc.org/articles/PMC4984974/
https://europepmc.org/articles/PMC4984974/
Autor:
Rachel Milne, Mark Craighead, Fiona Thomson, Hugh M. Marston, Leigh Campbell-Wan, Jeremy Presland, Lynn Watson, Cliona P MacSweeney
It has been argued that hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis is a major biological abnormality in patients suffering from psychiatric conditions such as major depression. Both arginine vasopressin (AVP) and corticotrophin re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9a4cdf03d85b718a5f30d90641389ef
https://doi.org/10.1016/s0079-6123(08)00440-8
https://doi.org/10.1016/s0079-6123(08)00440-8
Autor:
Fiona Thomson, Stafford L. Lightman, Cliona P MacSweeney, M Grassie, Mark Craighead, SA Wood, Francesca Spiga, Louise R Harrison, Helen C. Atkinson
Publikováno v:
University of Bristol-PURE
The activity of the hypothalamic-pituitary-adrenal (HPA) axis is characterised both by an ultradian pulsatile pattern of glucocorticoid secretion and an endogenous diurnal rhythm. Glucocorticoid feedback plays a major role in regulating HPA axis acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbed20acc2feca3e43fdc844df1bca59
https://pubmed.ncbi.nlm.nih.gov/17927667
https://pubmed.ncbi.nlm.nih.gov/17927667
Publikováno v:
European journal of pharmacology. 318(2-3)
The forced swimming test is a behavioural model developed to predict the efficacy of antidepressant drugs. Few studies have been aimed at evaluating the mechanism of action of antidepressants in the forced swimming test. The present study was designe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b29b1e63caef21bc324042d89846df6
https://pubmed.ncbi.nlm.nih.gov/9016908
https://pubmed.ncbi.nlm.nih.gov/9016908