Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Cliona M. O'Mahony"'
Publikováno v:
Pharmacology Biochemistry and Behavior; Vol 97
The neurochemical basis of depression focuses on alterations in the monoaminergic and amino acid neurotransmitter systems. Moreover, decreases in serum levels of the neurotrophin brain-derived neurotrophic factor (BDNF) have led to the more recent ne
Publikováno v:
Neuroscience Letters; Vol 482
There is increasing evidence to suggest that metabotropic glutamate (mGlu) receptors including mGlu(7) receptor are important in the pathophysiology of stress-related psychiatric disorders such as anxiety and major depression. mGlu(7) receptor is hig
Autor:
John F. Cryan, Niall P. Hyland, Siobhain M. O'Mahony, Timothy G. Dinan, Cliona M. O'Mahony, Dervla O'Malley
Publikováno v:
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 27(1)
Background Early-life stress and a genetic predisposition to display an anxiety- and depressive-like phenotype are associated with behavioral and gastrointestinal (GI) dysfunction. Animals exposed to early-life stress, and those genetically predispos
Autor:
Cliona M. O'Mahony, Marcela Julio-Pieper, John F. Cryan, Javier A. Bravo, Timothy G. Dinan, Gerard Clarke
Publikováno v:
Stress (Amsterdam, Netherlands). 15(2)
Mood disorders and chronic stress are frequently associated with gastrointestinal (GI) symptoms including diarrhoea or constipation. Locally produced serotonin [5-hydroxytryptamine (5-HT)] regulates GI motility and is a key factor in the pathophysiol
Publikováno v:
Behavioural Brain Research; Vol 213
Genetically identical inbred mouse strains are one of the most useful tools in dissecting the genetic basis of complex disorders. C57BL/6 and BALB/c mice differ markedly in emotionality. In particular, BALB/c mice are more stress-sensitive and have b
Autor:
Karen Bannerton, Dara Bree, Cliona M. O'Mahony, Daniel Broom, Orla Moriarty, Bradley Morris, David P. Finn, John P. Kelly, Michelle Roche
Publikováno v:
The Journal of Pain. 16:421-435.e6
Acute postoperative pain remains a significant health care issue. Development of anatomically relevant animal models of postoperative pain, with improved predictive validity, would advance understanding of postoperative pain mechanisms and improve tr
Autor:
Timothy G. Dinan, Fergus Shanahan, Mónica Tramullas, Patrick Fitzgerald, John F. Cryan, Gerard Clarke, Sue Grenham, Cliona M. O'Mahony, Declan P. McKernan, Paul Scully
Publikováno v:
Brain, Behavior, and Immunity. 24:S55-S56
Publikováno v:
European Neuropsychopharmacology. 19:S46-S47
Method: 34 participants were randomised to receive a single oral dose of either 5mg aripiprazole (n = 12), 1mg risperidone (n = 11), or placebo (n = 11) following a double blind study design. Particpants were instructed in the the N-Back task of work
Publikováno v:
European Neuropsychopharmacology. 23:S509
Autor:
Patrick Fitzgerald, Mónica Tramullas, Sue Grenham, Declan P. McKernan, Cliona M. O'Mahony, Gerard Clarke, Fergus Shanahan, Timothy G. Dinan, John F. Cryan, Paul Scully
Publikováno v:
Gastroenterology. 138:S-141