Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Clinton M, Heinze"'
Autor:
Zachary S Morris, Jasdeep Kler, Kyung Mann Kim, Emily I Guy, Paul A Clark, Raghava N Sriramaneni, Won Jong Jin, Justin C Jagodinsky, Amber M Bates, Abigail A Jaquish, Bryce R Anderson, Trang Le, Jonathan A Lubin, Ishan Chakravarty, Ian S Arthur, Clinton M Heinze, Kelsey A Klar, Peter M Carlson, John S Kuo
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Immune checkpoint inhibition (ICI) alone is not efficacious for a large number of patients with melanoma brain metastases. We previously established an in situ vaccination (ISV) regimen combining radiation and immunocytokine to enhance res
Externí odkaz:
https://doaj.org/article/5403053984ba479cad7610cc87ac2b46
Autor:
Claire C. Baniel, Clinton M. Heinze, Anna Hoefges, Elizabeth G. Sumiec, Jaquelyn A. Hank, Peter M. Carlson, Won Jong Jin, Ravi B. Patel, Raghava N. Sriramaneni, Stephen D. Gillies, Amy K. Erbe, Ciara N. Schwarz, Alexander A. Pieper, Alexander L. Rakhmilevich, Paul M. Sondel, Zachary S. Morris
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
In a syngeneic murine melanoma (MEL) model, we recently reported an in situ vaccination response to combined radiation (RT) and intra-tumoral (IT) injection of anti-GD2 hu14. 18-IL2 immunocytokine (IC). This combined treatment resulted in 71% complet
Externí odkaz:
https://doaj.org/article/69d352c38672413f9676b26e4741f6de
Autor:
Paul M. Sondel, Paul M. Harari, Alexander L. Rakhmilevich, Jacquelyn A. Hank, Amy K. Erbe, Alan J. Korman, Stephen D. Gillies, Hans Loibner, Lakeesha L. Carmichael, Raghava N. Sriramaneni, Abigail A. Jaquish, Sara M. Busche, Jasdeep S. Kler, Clinton M. Heinze, Peter M. Carlson, Lauryn R. Werner, Emily I. Guy, Zachary S. Morris
Concomitant immune tolerance prevents an immunotherapeutic response at the distant tumor site, is observed with an 8 Gy x 3 fraction RT regimen, and requires a well-established macroscopic secondary tumor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92254349c1fed9f2a810f37376c5a2d7
https://doi.org/10.1158/2326-6066.22539017.v1
https://doi.org/10.1158/2326-6066.22539017.v1
Autor:
Paul M. Sondel, Paul M. Harari, Alexander L. Rakhmilevich, Jacquelyn A. Hank, Amy K. Erbe, Alan J. Korman, Stephen D. Gillies, Hans Loibner, Lakeesha L. Carmichael, Raghava N. Sriramaneni, Abigail A. Jaquish, Sara M. Busche, Jasdeep S. Kler, Clinton M. Heinze, Peter M. Carlson, Lauryn R. Werner, Emily I. Guy, Zachary S. Morris
In situ vaccination is an emerging cancer treatment strategy that uses local therapies to stimulate a systemic antitumor immune response. We previously reported an in situ vaccination effect when combining radiation (RT) with intratumor (IT) injectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e318cbf624cef92a30ae9c67df48f38
https://doi.org/10.1158/2326-6066.c.6548969
https://doi.org/10.1158/2326-6066.c.6548969
Autor:
Paul M. Sondel, Paul M. Harari, Alexander L. Rakhmilevich, Jacquelyn A. Hank, Amy K. Erbe, Alan J. Korman, Stephen D. Gillies, Hans Loibner, Lakeesha L. Carmichael, Raghava N. Sriramaneni, Abigail A. Jaquish, Sara M. Busche, Jasdeep S. Kler, Clinton M. Heinze, Peter M. Carlson, Lauryn R. Werner, Emily I. Guy, Zachary S. Morris
Supplemental Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94e0aef92280465dad14cf60df132bde
https://doi.org/10.1158/2326-6066.22539008.v1
https://doi.org/10.1158/2326-6066.22539008.v1
Autor:
Alan J. Korman, Jacquelyn A. Hank, Zachary S. Morris, Stephen D. Gillies, Paul M. Harari, Hans Loibner, Sara M. Busche, Emily I. Guy, Alexander L. Rakhmilevich, Lakeesha Carmichael, Lauryn R. Werner, Paul M. Sondel, Abigail A Jaquish, Raghava N. Sriramaneni, Jasdeep S. Kler, Amy K. Erbe, Clinton M. Heinze, Peter M. Carlson
Publikováno v:
Cancer Immunology Research. 6:825-834
In situ vaccination is an emerging cancer treatment strategy that uses local therapies to stimulate a systemic antitumor immune response. We previously reported an in situ vaccination effect when combining radiation (RT) with intratumor (IT) injectio
Autor:
Ravi Patel, Zachary S. Morris, Amy K. Erbe, Maureen Riegert, Lauryn R. Werner, Clinton M. Heinze, Joseph Kern, Mahyar Abbariki, Raghava N. Sriramaneni, Lindsey K. Werner, Monica M. Gressett, Paul M. Harari, Jasdeep S. Kler
Publikováno v:
Radiotherapy and Oncology. 124:418-426
Background and purpose We recently reported a time-sensitive, cooperative, anti-tumor effect elicited by radiation (RT) and intra-tumoral-immunocytokine injection in vivo . We hypothesized that RT triggers transcriptional-mediated changes in tumor ex
Autor:
Zachary S, Morris, Emily I, Guy, Lauryn R, Werner, Peter M, Carlson, Clinton M, Heinze, Jasdeep S, Kler, Sara M, Busche, Abigail A, Jaquish, Raghava N, Sriramaneni, Lakeesha L, Carmichael, Hans, Loibner, Stephen D, Gillies, Alan J, Korman, Amy K, Erbe, Jacquelyn A, Hank, Alexander L, Rakhmilevich, Paul M, Harari, Paul M, Sondel
Publikováno v:
Cancer immunology research. 6(7)
In situ vaccination is an emerging cancer treatment strategy that uses local therapies to stimulate a systemic antitumor immune response. We previously reported an in situ vaccination effect when combining radiation (RT) with intra-tumor (IT) injecti