Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Clinton G. Mikek"'
Autor:
Clinton G. Mikek, Savannah J. West, J. Cole Gwin, Neetu Dayal, Herman O. Sintim, Edwin A. Lewis
Publikováno v:
ACS Omega, Vol 3, Iss 9, Pp 11582-11591 (2018)
Externí odkaz:
https://doaj.org/article/02b666152b8946b6a0eba67c42496286
Autor:
Herman O. Sintim, Neetu Dayal, Brandon Carter-Cooper, George A Naclerio, Delmis E. Hernandez, Clinton G. Mikek, Rena G. Lapidus, Elizabeth Fei Yin Chu
Publikováno v:
European Journal of Medicinal Chemistry. 180:449-456
Rho-associated protein kinases (ROCKs) are ubiquitously expressed in most adult tissues, and are involved in modulating the cytoskeleton, protein synthesis and degradation pathways, synaptic function, and autophagy to list a few. A few ROCK inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ed90d843ed2f78a2ed8048ae571b784
https://doi.org/10.1016/j.ejmech.2019.06.089
https://doi.org/10.1016/j.ejmech.2019.06.089
Publikováno v:
Medchemcomm
The cyclic dinucleotide-cGAS–STING axis plays important roles in host immunity. Activation of this signaling pathway, via cytosolic sensing of bacterial-derived c-di-GMP/c-di-AMP or host-derived cGAMP, leads to the production of inflammatory interf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5efecafc8a85f04265a06bf5195f04ab
https://doi.org/10.1039/c8md00555a
https://doi.org/10.1039/c8md00555a
Publikováno v:
Biochemistry and Biophysics Reports, Vol 12, Iss C, Pp 158-165 (2017)
Linker histones (H1) are the basic proteins in higher eukaryotes that are responsible for the final condensation of chromatin. In contrast to the nucleosome core histone proteins, the role of H1 in compacting DNA is not clearly understood. In this st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f807a456cb27a2a99d11e69205af5e
http://www.sciencedirect.com/science/article/pii/S240558081730184X
http://www.sciencedirect.com/science/article/pii/S240558081730184X
Autor:
Frederick M. MacDonnell, J. Cole Gwin, Logan R. Martin, Jake C. White, Nagham Alatrash, Savannah J. West, Clinton G. Mikek, Carmen Shumaker, Edwin A. Lewis, Venkata R. Machha, Arseniy Butrin
Publikováno v:
European Journal of Inorganic Chemistry. 2017:3953-3960
ITC and CD were used to study the thermodynamics of RPC*G-quadruplex DNA (G4) complex formation. RPCs were [Ru(phen)₃]²+ (1²+), [Ru(phen)₂(dppz)]²+ (2²+), [Ru(phen)₂(tatpp)]²+ (3²+), and [Ru(phen)₂(tatpp)(phen)₂Ru]⁴+ (4⁴+) and tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff811de0b195f6be20618f9dc4d3b103
https://doi.org/10.1002/ejic.201700789
https://doi.org/10.1002/ejic.201700789
Autor:
Frederick M. MacDonnell, Jake C. White, Logan R. Martin, Nagham Alatrash, Edwin A. Lewis, Venkata R. Machha, Jesse I. DuPont, Clinton G. Mikek
Publikováno v:
European Journal of Inorganic Chemistry. 2017:3604-3611
ITC, CD, and ESI-MS techniques were used to study the thermodynamics of RPC*DNA complex formation for binding three different RPCs to duplex DNA. RPCs were [Ru(phen)₃]2+ (1), [Ru(phen)₂(dppz)]2+ (2), and [Ru(phen)₂(tatpp)]2+ (3). We examined th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f8613ea42dafc1a7f0451b4e35353ac
https://doi.org/10.1002/ejic.201700462
https://doi.org/10.1002/ejic.201700462
Autor:
Clinton G. Mikek, Edwin A. Lewis, Min Guo, Benjamin T. Roembke, Brandon Carter-Cooper, Jie Zhou, Herman O. Sintim, Musabbir A. Saeed, Jinbing Liu, Rena G. Lapidus, Changhao Wang, Yixuan Du
Publikováno v:
European Journal of Medicinal Chemistry. 118:266-275
G-quadruplex ligands have been touted as potential anticancer agents, however, none of the reported G-quadruplex-interactive small molecules have gone past phase II clinical trials. Recently it was revealed that diminazene (berenil, DMZ) actually bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4910eb21c4af73d25e80b810499268ce
Autor:
Moloud Aflaki Sooreshjani, Modi Wang, Clinton G. Mikek, Herman O. Sintim, Clement Opoku-Temeng
Publikováno v:
Future medicinal chemistry. 10(11)
Aim: Persistent activation of STING pathway is the basis for several autoimmune diseases. STING is activated by cGAMP, which is produced by cGAS in the presence of DNA. Results/methodology: HPLC-based medium throughput screening for inhibitors of cGA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8138a887a9ef3d00e66f43d1de3a22ad
https://pubmed.ncbi.nlm.nih.gov/29558821
https://pubmed.ncbi.nlm.nih.gov/29558821
Autor:
Jake C. White, Nagham Alatrash, Jesse I. DuPont, Clinton G. Mikek, Edwin A. Lewis, Venkata R. Machha, Frederick M. MacDonnell, Logan R. Martin
Publikováno v:
European Journal of Inorganic Chemistry. 2017:3587-3587
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d075b14016229d0726037efd6e78fef9
https://doi.org/10.1002/ejic.201700777
https://doi.org/10.1002/ejic.201700777
Autor:
Clinton G. Mikek, Jesse I. DuPont, Venkata R. Machha, Jake C. White, Logan R. Martin, Nagham Alatrash, Frederick M. MacDonnell, Edwin A. Lewis
Publikováno v:
European Journal of Inorganic Chemistry. 2017:3588-3588
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b67811d31a7028169b9b9dcf4dc0c1b7
https://doi.org/10.1002/ejic.201700778
https://doi.org/10.1002/ejic.201700778