Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Clinton Elfers"'
Publikováno v:
Journal of Obesity, Vol 2011 (2011)
Low-serum concentrations of 25-hydroxyvitamin D [25(OH)D] are associated with insulin resistance in adults. Less data are available in pediatric populations. Serum 25(OH)D serum concentrations were assessed in 125 obese and 31 nonobese children (age
Externí odkaz:
https://doaj.org/article/4c1f5562216c4415a67d75ffeea73251
Autor:
Ashley H. Shoemaker, Heidi J. Silver, Maciej Buchowski, James C. Slaughter, Jack A. Yanovski, Clinton Elfers, Christian L. Roth, M. Jennifer Abuzzahab
Publikováno v:
International Journal of Obesity. 46:623-629
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7244a2e4174d876d44fc5552cabf5d2b
https://doi.org/10.1038/s41366-021-01043-6
https://doi.org/10.1038/s41366-021-01043-6
Autor:
Christian L. Roth, Oleg G. Chepurny, Bart C. De Jonghe, George G. Holz, Clinton Elfers, Kylie S. Chichura, Matthew R. Hayes, Tito Borner, Robert P. Doyle, Ian R. Sweet, Brandon T. Milliken
Publikováno v:
J Med Chem
There is a critical unmet need for therapeutics to treat the epidemic of comorbidities associated with obesity and type 2 diabetes, ideally devoid of nausea/emesis. This study developed monomeric peptide agonists of glucagon-like peptide 1 receptor (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f87628e79fa1735fd176ff82760e989
https://doi.org/10.1021/acs.jmedchem.0c01783
https://doi.org/10.1021/acs.jmedchem.0c01783
Autor:
Kylie Chichura, Clinton Elfers, Therese Salameh, Ian Sweet, Christian Roth, Prof Robert Doyle
Publikováno v:
Journal of the Endocrine Society. 6:A418-A419
Current treatments for type 2 diabetes (T2D) and obesity do not reliably achieve long-term weight-loss and up to 50% of patients experience nausea and vomiting. Thus, there is a critical need for obesity medications that provide glycemic control with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f9e3363f1b09621ba24e2cb1777172c
https://doi.org/10.1210/jendso/bvac150.871
https://doi.org/10.1210/jendso/bvac150.871
Autor:
M. Jennifer Abuzzahab, Jack A. Yanovski, Clinton Elfers, Christian L. Roth, Ashley H. Shoemaker, Kathryn B. Whitlock, Francisco A. Perez
Publikováno v:
Diabetes, Obesity & Metabolism
Aim To evaluate the efficacy, safety and tolerability of a glucagon‐like peptide‐1 receptor agonist (GLP‐1 RA) in patients with hypothalamic obesity (HO). Materials and Methods A two‐arm, randomized, multicentre, double‐blind, placebo‐con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b42b006eb965282e626072a0f297665
http://europepmc.org/articles/PMC7821019
http://europepmc.org/articles/PMC7821019
Autor:
Kelley Scholz, Brian E. Saelens, Mary Rosalynn B. De Leon, Christian L. Roth, Susan J. Melhorn, Clinton Elfers, Maya Rowland, Ellen A. Schur
Publikováno v:
International journal of obesity (2005)
Background and Objectives: Family-based behavioral treatment (FBT) is the recommended treatment for children with common obesity. However, there is a large variability in short- and long-term treatment response and mechanisms for unsuccessful treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b87e31a2f6906cbfedea625baf8bda05
http://europepmc.org/articles/PMC7530004
http://europepmc.org/articles/PMC7530004
Autor:
Richard Pittner, Elizabeth A. Lawson, Alex Kiselyov, Clinton Elfers, Christian L. Roth, David Silva, James E. Blevins
Publikováno v:
Frontiers in Physiology
Frontiers in Physiology, Vol 12 (2021)
Frontiers in Physiology, Vol 12 (2021)
Background: Oxytocin is a hypothalamic neuropeptide that participates in the network of appetite regulation. Recently the oxytocin signaling pathway has emerged as an attractive target for treating obesity. However, the short half-life limits its dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a939a17f3b48e2659cdc383bfc172aa5
Autor:
Ashley H, Shoemaker, Heidi J, Silver, Maciej, Buchowski, James C, Slaughter, Jack A, Yanovski, Clinton, Elfers, Christian L, Roth, M Jennifer, Abuzzahab
Publikováno v:
International journal of obesity (2005). 46(3)
Hypothalamic obesity (HO) frequently occurs following suprasellar tumors from a combination of decreased energy expenditure and increased energy intake. Glucagon-like peptide-1 receptor agonist (GLP1RA) therapy is associated with increased satiety an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::85d3d6728e155b4a4c9e951ff473c774
https://pubmed.ncbi.nlm.nih.gov/34975146
https://pubmed.ncbi.nlm.nih.gov/34975146
Autor:
Francisco A. Perez, M. Jennifer Abuzzahab, Jack A. Yanovski, Clinton Elfers, Christian L. Roth, Ashley H. Shoemaker
Publikováno v:
Diabetes Obes Metab
AIM To evaluate whether neuroimaging-delineated regions of hypothalamic injury are associated with a differential treatment response to a glucagon-like peptide-1 receptor agonist (GLP-1RA) in patients with hypothalamic obesity (HO). MATERIALS AND MET
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757867025fded74d90e6da9cb7d823e5
https://pubmed.ncbi.nlm.nih.gov/33651438
https://pubmed.ncbi.nlm.nih.gov/33651438