Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Clinton E Canal"'
Autor:
Uade B Olaghere Da Silva, Michael V Morabito, Clinton E Canal, David C Airey, Ronald B Emeson, Elaine Sanders-Bush
Publikováno v:
Frontiers in Neuroscience, Vol 4 (2010)
Transcripts encoding 5-HT2C receptors are modified posttranscriptionally by RNA editing, generating up to 24 protein isoforms. In recombinant cells, the fully edited isoform, 5-HT2C-VGV, exhibits blunted G-protein coupling and reduced constitutive ac
Externí odkaz:
https://doaj.org/article/ba24d819bba5466da6eb2677ee25a476
Publikováno v:
ACS Chemical Neuroscience. 13:3629-3640
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Central Nervous System Pharmacology - Behavioral.
Autor:
Jessica L. Armstrong, Clinton E. Canal
Publikováno v:
The FASEB Journal. 36
Publikováno v:
The FASEB Journal. 36
Publikováno v:
Biochem Pharmacol
Blockade of the serotonin 5-HT(2A) G protein-coupled receptor (5-HT(2A)R) is a fundamental pharmacological characteristic of numerous antipsychotic medications, which are FDA-approved to treat schizophrenia, bipolar disorder, and as adjunctive therap
Autor:
Jessica L Armstrong, Munmun Mukherjee, Tanishka S Saraf, Clinton E. Canal, Austen B. Casey, Raymond G. Booth
Publikováno v:
ACS Pharmacology & Translational Science. 3:509-523
Fragile X syndrome (FXS) is a neurodevelopmental disorder characterized by intellectual disabilities and a plethora of neuropsychiatric symptoms. FXS is the leading monogenic cause of autism spectrum disorder (ASD), which is defined clinically by rep
Autor:
Yiming Chen, Clinton E. Canal
Publikováno v:
ACS Chemical Neuroscience. 11:960-968
Synthetic cathinones (SCs) are designer, psychostimulant drugs of abuse that primarily act on monoamine transporters; little is known about their off-target liability. Abuse of pyrrolidine-containi...
Publikováno v:
Epilepsy Res
The prevalence of seizures in individuals with fragile X syndrome (FXS) is ~25%; however, there are no reports of spontaneous seizures in the Fmr1 knockout mouse model of FXS. Herein, we report that 48% of adult (median age P96), Fmr1 knockout mice f
Autor:
Luis F. Restrepo, Erin C. Berthold, Aidan J. Hampson, Avi Patel, Lance R. McMahon, Carolina Lopera-Londoño, Takato Hiranita, Shyam H. Kamble, Samuel Obeng, Abhisheak Sharma, Lea R. Gamez-Jimenez, Francisco León, Clinton E. Canal, Marco Mottinelli, Christopher R. McCurdy, Yiming Chen, Tamara I. King
Publikováno v:
J Med Chem
Kratom alkaloids have mostly been evaluated for their opioid activity but less at other targets that could contribute to their physiological effects. Here, we investigated the in vitro and in vivo activity of kratom alkaloids at serotonin receptors (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::749b326c3ebef7e4aed6ae82cdd6614a
https://europepmc.org/articles/PMC9235362/
https://europepmc.org/articles/PMC9235362/