Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Clint L. Makino"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Rod photoreceptors in the retina adjust their responsiveness and sensitivity so that they can continue to provide meaningful information over a wide range of light intensities. By stimulating membrane guanylate cyclases in the outer segment to synthe
Externí odkaz:
https://doaj.org/article/52da2cb627814f1caec733ace6f69f41
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Externí odkaz:
https://doaj.org/article/6972b15d6efe4d2f9ceacf2e581647a7
Autor:
Giovanni Caruso, Colin Klaus, Heidi E. Hamm, Vsevolod V. Gurevich, Paolo Bisegna, Daniele Andreucci, Emmanuele DiBenedetto, Clint L. Makino
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2023)
Retinal rods evolved to be able to detect single photons. Despite their exquisite sensitivity, rods operate over many log units of light intensity. Several processes inside photoreceptor cells make this incredible light adaptation possible. Here, we
Externí odkaz:
https://doaj.org/article/5e6823c4d31b43a888fb036601b0ea7d
Autor:
Polina Geva, Giovanni Caruso, Colin Klaus, Heidi E. Hamm, Vsevolod V. Gurevich, Emmanuele DiBenedetto, Clint L. Makino
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Accurate photon counting requires that rods generate highly amplified, reproducible single photon responses (SPRs). The SPR is generated within the rod outer segment (ROS), a multilayered structure built from membranous disks that house rhodopsin. Ph
Externí odkaz:
https://doaj.org/article/fe3df3c0174a40f28486ece3f8b606c3
Autor:
Colin Klaus, Giovanni Caruso, Vsevolod V. Gurevich, Heidi E. Hamm, Clint L. Makino, Emmanuele DiBenedetto
Publikováno v:
PLoS ONE, Vol 16, Iss 10 (2021)
In daylight, cone photoreceptors in the retina are responsible for the bulk of visual perception, yet compared to rods, far less is known quantitatively about their biochemistry. This is partly because it is hard to isolate and purify cone proteins.
Externí odkaz:
https://doaj.org/article/a17d3d185c0b4bea99d37b1564483c72
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 7 (2014)
In vertebrate rods and cones, photon capture by rhodopsin leads to the destruction of cyclic GMP (cGMP) and the subsequent closure of cyclic nucleotide gated (CNG) ion channels in the outer segment plasma membrane. Replenishment of cGMP and reopening
Externí odkaz:
https://doaj.org/article/803d021ecbac4844bed9ceaf26db1933
Autor:
Giovanni Caruso, Colin Klaus, Emmanuele DiBenedetto, Vsevolod V. Gurevich, Clint L. Makino, Heidi E. Hamm
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 10, p e0240527 (2020)
PLoS ONE, Vol 15, Iss 10, p e0240527 (2020)
Retinal rods function as accurate photon counters to provide for vision under very dim light. To do so, rods must generate highly amplified, reproducible responses to single photons, yet outer segment architecture and randomness in the location of rh
Autor:
Vsevolod V. Gurevich, Emmanuele DiBenedetto, Heidi E. Hamm, Clint L. Makino, Giovanni Caruso, Colin Klaus
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0258721 (2021)
PLoS ONE, Vol 16, Iss 10 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 10 (2021)
PLoS ONE
In daylight, cone photoreceptors in the retina are responsible for the bulk of visual perception, yet compared to rods, far less is known quantitatively about their biochemistry. This is partly because it is hard to isolate and purify cone proteins.
Autor:
Alexandre Pertzev, Michael A. Sandberg, Rameshwar K. Sharma, Polina Geva, Tomoki Isayama, Clint L. Makino, Teresa Duda
Publikováno v:
eNeuro
The membrane guanylate cyclase, ROS-GC, that synthesizes cyclic GMP for use as a second messenger for visual transduction in retinal rods and cones, is stimulated by bicarbonate. Bicarbonate acts directly on ROS-GC1, because it enhanced the enzymatic
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1753
Our ability to see is based on the activity of retinal rod and cone photoreceptors. Rods function when there is very little light, while cones operate at higher light levels. Photon absorption by rhodopsin activates a biochemical cascade that convert