Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Clint L. Makino"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Rod photoreceptors in the retina adjust their responsiveness and sensitivity so that they can continue to provide meaningful information over a wide range of light intensities. By stimulating membrane guanylate cyclases in the outer segment to synthe
Externí odkaz:
https://doaj.org/article/52da2cb627814f1caec733ace6f69f41
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Externí odkaz:
https://doaj.org/article/6972b15d6efe4d2f9ceacf2e581647a7
Autor:
Giovanni Caruso, Colin Klaus, Heidi E. Hamm, Vsevolod V. Gurevich, Paolo Bisegna, Daniele Andreucci, Emmanuele DiBenedetto, Clint L. Makino
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2023)
Retinal rods evolved to be able to detect single photons. Despite their exquisite sensitivity, rods operate over many log units of light intensity. Several processes inside photoreceptor cells make this incredible light adaptation possible. Here, we
Externí odkaz:
https://doaj.org/article/5e6823c4d31b43a888fb036601b0ea7d
Autor:
Polina Geva, Giovanni Caruso, Colin Klaus, Heidi E. Hamm, Vsevolod V. Gurevich, Emmanuele DiBenedetto, Clint L. Makino
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Accurate photon counting requires that rods generate highly amplified, reproducible single photon responses (SPRs). The SPR is generated within the rod outer segment (ROS), a multilayered structure built from membranous disks that house rhodopsin. Ph
Externí odkaz:
https://doaj.org/article/fe3df3c0174a40f28486ece3f8b606c3
Autor:
Colin Klaus, Giovanni Caruso, Vsevolod V. Gurevich, Heidi E. Hamm, Clint L. Makino, Emmanuele DiBenedetto
Publikováno v:
PLoS ONE, Vol 16, Iss 10 (2021)
In daylight, cone photoreceptors in the retina are responsible for the bulk of visual perception, yet compared to rods, far less is known quantitatively about their biochemistry. This is partly because it is hard to isolate and purify cone proteins.
Externí odkaz:
https://doaj.org/article/a17d3d185c0b4bea99d37b1564483c72
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 9 (2016)
Photoreceptor ROS-GC1, a prototype subfamily member of the membrane guanylate cyclase family, is a central component of phototransduction. It is a single transmembrane-spanning protein, composed of modular blocks. In rods, guanylate cyclase activatin
Externí odkaz:
https://doaj.org/article/e77792d80a324d21a3642016d525f54b
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 7 (2014)
In vertebrate rods and cones, photon capture by rhodopsin leads to the destruction of cyclic GMP (cGMP) and the subsequent closure of cyclic nucleotide gated (CNG) ion channels in the outer segment plasma membrane. Replenishment of cGMP and reopening
Externí odkaz:
https://doaj.org/article/803d021ecbac4844bed9ceaf26db1933
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 7 (2014)
Photoreceptor rod outer segment membrane guanylate cyclase (ROS-GC) is central to visual transduction; it generates cyclic GMP, the second messenger of the photon signal. Photoexcited rhodopsin initiates a biochemical cascade that leads to a drop in
Externí odkaz:
https://doaj.org/article/81d8f41f4ed7427d9b7558caf30a630a
Autor:
Giovanni Caruso, Colin Klaus, Emmanuele DiBenedetto, Vsevolod V. Gurevich, Clint L. Makino, Heidi E. Hamm
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 10, p e0240527 (2020)
PLoS ONE, Vol 15, Iss 10, p e0240527 (2020)
Retinal rods function as accurate photon counters to provide for vision under very dim light. To do so, rods must generate highly amplified, reproducible responses to single photons, yet outer segment architecture and randomness in the location of rh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb9cd7af9f3d25ad7f0078faff412ce
http://europepmc.org/articles/PMC7556485
http://europepmc.org/articles/PMC7556485
Autor:
Clint L Makino, Xiao-Hong Wen, Elena V Olshevskaya, Igor V Peshenko, Andrey B Savchenko, Alexander M Dizhoor
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47637 (2012)
Regulation of cGMP synthesis by retinal membrane guanylyl cyclase isozymes (RetGC1 and RetGC2) in rod and cone photoreceptors by calcium-sensitive guanylyl cyclase activating proteins (GCAP1 and GCAP2) is one of the key molecular mechanisms affecting
Externí odkaz:
https://doaj.org/article/f620b9f3b9f145fdb68e0aa4d7ef4ff9