Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Clinical Puzzle"'
Publikováno v:
Disease Models & Mechanisms
article-version (VoR) Version of Record
Disease Models & Mechanisms, Vol 13, Iss 9 (2020)
article-version (VoR) Version of Record
Disease Models & Mechanisms, Vol 13, Iss 9 (2020)
Heterotopic ossification (HO) is a disorder characterised by the formation of ectopic bone in soft tissue. Acquired HO typically occurs in response to trauma and is relatively common, yet its aetiology remains poorly understood. Genetic forms, by con
Autor:
Lea-Ann S. Kirkham, Michael Cheeseman, Joseph E. Kerschner, Mahmood F. Bhutta, Ruth B. Thornton
Publikováno v:
Disease Models & Mechanisms
Disease Models & Mechanisms, Vol 10, Iss 11, Pp 1289-1300 (2017)
Bhutta, M F, Thornton, R B, Kirkham, L-A S, Kerschner, J E & Cheeseman, M T 2017, ' Understanding the aetiology and resolution of chronic otitis media from animal and human studies ', Disease Models and Mechanisms, vol. 10, no. 11, pp. 1289-1300 . https://doi.org/10.1242/dmm.029983, https://doi.org/10.1242/dmm.029983
Disease Models & Mechanisms, Vol 10, Iss 11, Pp 1289-1300 (2017)
Bhutta, M F, Thornton, R B, Kirkham, L-A S, Kerschner, J E & Cheeseman, M T 2017, ' Understanding the aetiology and resolution of chronic otitis media from animal and human studies ', Disease Models and Mechanisms, vol. 10, no. 11, pp. 1289-1300 . https://doi.org/10.1242/dmm.029983, https://doi.org/10.1242/dmm.029983
Inflammation of the middle ear, known clinically as chronic otitis media, presents in different forms, such as chronic otitis media with effusion (COME; glue ear) and chronic suppurative otitis media (CSOM). These are highly prevalent diseases, espec
Publikováno v:
Disease Models & Mechanisms
Disease Models & Mechanisms, Vol 7, Iss 11, Pp 1205-1213 (2014)
Disease Models & Mechanisms, Vol 7, Iss 11, Pp 1205-1213 (2014)
The efficient healing of a skin wound is something that most of us take for granted but is essential for surviving day-to-day knocks and cuts, and is absolutely relied on clinically whenever a patient receives surgical intervention. However, the mana
Publikováno v:
Disease Models & Mechanisms, Vol 7, Iss 4, Pp 411-419 (2014)
Disease Models & Mechanisms
Disease Models & Mechanisms
The classical form of α1-antitrypsin deficiency (ATD) is an autosomal co-dominant disorder that affects ~1 in 3000 live births and is an important genetic cause of lung and liver disease. The protein affected, α1-antitrypsin (AT), is predominantly
Publikováno v:
Disease Models & Mechanisms
Disease Models & Mechanisms, Vol 6, Iss 4, Pp 877-888 (2013)
Disease Models & Mechanisms, Vol 6, Iss 4, Pp 877-888 (2013)
Asthmatics with a severe form of the disease are frequently refractory to standard medications such as inhaled corticosteroids, underlining the need for new treatments to prevent the occurrence of potentially life-threatening episodes. A major obstac
Publikováno v:
Disease Models & Mechanisms
Disease Models & Mechanisms, Vol 6, Iss 2, Pp 281-292 (2013)
Disease Models & Mechanisms, Vol 6, Iss 2, Pp 281-292 (2013)
Cholangiocarcinoma is a fatal cancer of the biliary epithelium and has an incidence that is increasing worldwide. Survival beyond a year of diagnosis is less than 5%, and therapeutic options are few. Known risk factors include biliary diseases such a
Publikováno v:
Disease Models & Mechanisms
Disease Models & Mechanisms, Vol 6, Iss 1, Pp 9-17 (2013)
Disease Models & Mechanisms, Vol 6, Iss 1, Pp 9-17 (2013)
Idiopathic pulmonary fibrosis (IPF) is a progressive and often fatal lung disease for which there is no known treatment. Although the traditional paradigm of IPF pathogenesis emphasized chronic inflammation as the primary driver of fibrotic remodelin
Autor:
Philipp Mergenthaler, Andreas Meisel
Publikováno v:
Disease Models & Mechanisms, Vol 5, Iss 6, Pp 718-725 (2012)
Disease Models & Mechanisms
Disease Models & Mechanisms; Vol 5
Disease Models & Mechanisms
Disease Models & Mechanisms; Vol 5
Stroke is one of the leading causes of death worldwide and the biggest reason for long-term disability. Basic research has formed the modern understanding of stroke pathophysiology, and has revealed important molecular, cellular and systemic mechanis
Autor:
Edmond H. M. M. Rings, Carsten Posovszky, Ben N G Giepmans, Sven C.D. van IJzendoorn, Arend W. Overeem
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 1, Pp 1-12 (2016)
Disease Models and Mechanisms, 9(1), 1-12
Disease models & mechanisms, 9(1), 1-12. COMPANY OF BIOLOGISTS LTD
Disease Models & Mechanisms, 9(1), 1-12. Company of Biologists Ltd
Disease Models & Mechanisms
Disease Models and Mechanisms, 9(1), 1-12
Disease models & mechanisms, 9(1), 1-12. COMPANY OF BIOLOGISTS LTD
Disease Models & Mechanisms, 9(1), 1-12. Company of Biologists Ltd
Disease Models & Mechanisms
Congenital diarrheal disorders are rare, often fatal, diseases that are difficult to diagnose (often requiring biopsies) and that manifest in the first few weeks of life as chronic diarrhea and the malabsorption of nutrients. The etiology of congenit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e358c1ec4ddd47dc88d651f8578a7167
https://hdl.handle.net/1887/113440
https://hdl.handle.net/1887/113440
Autor:
Jessica M. Schlitt, Laura C. Schulz, Kathleen A. Pennington, Danny J. Schust, Daniel L. Jackson
Publikováno v:
Disease Models & Mechanisms, Vol 5, Iss 1, Pp 9-18 (2012)
Disease Models & Mechanisms
Disease Models & Mechanisms
Preeclampsia is a pregnancy-specific disorder characterized by hypertension and excess protein excretion in the urine. It is an important cause of maternal and fetal morbidity and mortality worldwide. The disease is almost exclusive to humans and del