PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiency

Autor: Yunjong Lee, Sheila K. Pirooznia, Luan Wang, Senthilkumar S. Karuppagounder, Sung Ung Kang, Valina L. Dawson, Changqing Yuan, Mohammed Repon Khan, Yulan Xiong, Ted M. Dawson

Publikováno v: Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-21 (2020)
Molecular Neurodegeneration

Background Mutations in PINK1 and parkin cause autosomal recessive Parkinson’s disease (PD). Evidence placing PINK1 and parkin in common pathways regulating multiple aspects of mitochondrial quality control is burgeoning. However, compelling eviden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9264a302919fdf9855357b113f44a30
http://link.springer.com/article/10.1186/s13024-020-00363-x

A Glio-Protective Role of mir-263a by Tuning Sensitivity to Glutamate

Autor: Sherry Shiying Aw, Melissa Xue Mei Tang, Isaac Kok Hwee Lim, Stephen M. Cohen

Publikováno v: Aw, S S, Lim, I K H, Tang, M X M & Cohen, S M 2017, ' A Glio-Protective Role of mir-263a by Tuning Sensitivity to Glutamate ', Cell Reports, vol. 19, no. 9, pp. 1783-1793 . https://doi.org/10.1016/j.celrep.2017.05.010
Cell Reports, Vol 19, Iss 9, Pp 1783-1793 (2017)

Glutamate is a ubiquitous neurotransmitter, mediating information flow between neurons. Defects in the regulation of glutamatergic transmission can result in glutamate toxicity, which is associated with neurodegeneration. Interestingly, glutamate rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca4b15cdf345c7b8687728abe46952b1
https://pubmed.ncbi.nlm.nih.gov/28564598