Zobrazeno 1 - 10
of 2 969
pro vyhledávání: '"Clifton E"'
Publikováno v:
BMC Plant Biology, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background Sclerotinia spp. are generalist fungal pathogens, infecting over 700 plant hosts worldwide, including major crops. While host resistance is the most sustainable and cost-effective method for disease management, complete resistance
Externí odkaz:
https://doaj.org/article/c0d377b66ee44aafb402788a1dc6ea2a
Autor:
R. M. Naseer Khan, Yong-Mo Ahn, Gwendolyn A. Marriner, Laura E. Via, Francois D’Hooge, Seung Seo Lee, Nan Yang, Falguni Basuli, Alexander G. White, Jaime A. Tomko, L. James Frye, Charles A. Scanga, Danielle M. Weiner, Michelle L. Sutphen, Daniel M. Schimel, Emmanuel Dayao, Michaela K. Piazza, Felipe Gomez, William Dieckmann, Peter Herscovitch, N. Scott Mason, Rolf Swenson, Dale O. Kiesewetter, Keriann M. Backus, Yiqun Geng, Ritu Raj, Daniel C. Anthony, JoAnne L. Flynn, Clifton E. Barry, Benjamin G. Davis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Tuberculosis remains a large global disease burden for which treatment regimens are protracted and monitoring of disease activity difficult. Existing detection methods rely almost exclusively on bacterial culture from sputum which limits sam
Externí odkaz:
https://doaj.org/article/78179b9a20084b6790bf89a43f40ffbf
Autor:
Maral Budak, Laura E. Via, Danielle M. Weiner, Clifton E. Barry III, Pariksheet Nanda, Gabrielle Michael, Khisimuzi Mdluli, Denise Kirschner
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 4, Pp 673-685 (2024)
Abstract Tuberculosis (TB) is a life‐threatening infectious disease. The standard treatment is up to 90% effective; however, it requires the administration of four antibiotics (isoniazid, rifampicin, pyrazinamide, and ethambutol [HRZE]) over long t
Externí odkaz:
https://doaj.org/article/ed57ab311edd4ce7b47a12de44090263
Autor:
Meenal Datta, McCarthy Kennedy, Saeed Siri, Laura E Via, James W Baish, Lei Xu, Véronique Dartois, Clifton E Barry, Rakesh K Jain
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 2, p e1011847 (2024)
Physiological abnormalities in pulmonary granulomas-pathological hallmarks of tuberculosis (TB)-compromise the transport of oxygen, nutrients, and drugs. In prior studies, we demonstrated mathematically and experimentally that hypoxia and necrosis em
Externí odkaz:
https://doaj.org/article/b54bc0f89440443ca165ac06b7b9b370
Publikováno v:
Pharmaceuticals, Vol 17, Iss 2, p 211 (2024)
Tuberculosis (TB) is notorious as the leading cause of death worldwide due to a single infectious entity and its causative agent, Mycobacterium tuberculosis (Mtb), has been able to evolve resistance to all existing drugs in the treatment arsenal comp
Externí odkaz:
https://doaj.org/article/85007ad3f4864bfd8ade6f5af64aa29c
Autor:
Jansy P. Sarathy, Min Xie, Richard M. Jones, Adrienne Chang, Paulina Osiecki, Danielle Weiner, Wen-Shan Tsao, Maureen Dougher, Landry Blanc, Nader Fotouhi, Laura E. Via, Clifton E. Barry, Iwijn De Vlaminck, David R. Sherman, Véronique A. Dartois
Publikováno v:
mBio, Vol 14, Iss 2 (2023)
ABSTRACT Caseous necrosis is a hallmark of tuberculosis (TB) pathology and creates a niche for drug-tolerant persisters within the host. Cavitary TB and high bacterial burden in caseum require longer treatment duration. An in vitro model that recapit
Externí odkaz:
https://doaj.org/article/3362e75bb01a4154a6c86b4dffebc625
Autor:
Kira S. Makarova, Brittney Blackburne, Yuri I. Wolf, Anastasia Nikolskaya, Svetlana Karamycheva, Marlene Espinoza, Clifton E. Barry, Carole A. Bewley, Eugene V. Koonin
Publikováno v:
Biology Direct, Vol 17, Iss 1, Pp 1-22 (2022)
Abstract Background Bacteria and archaea produce an enormous diversity of modified peptides that are involved in various forms of inter-microbial conflicts or communication. A vast class of such peptides are Ribosomally synthesized, Postranslationall
Externí odkaz:
https://doaj.org/article/91f78b3e86694fbfae915c075d626b9e
Autor:
Kheyandra D. Lewis, Lauren Destino, Jennifer Everhart, Anupama Subramony, Benard Dreyer, Brenda Allair, Michele Anderson, Jennifer Baird, Zia Bismilla, Brian Good, Jennifer Hepps, Alisa Khan, Nicholas Kuzma, Christopher P. Landrigan, Katherine Litterer, Theodore C. Sectish, Nancy D. Spector, H. Shonna Yin, Clifton E. Yu, Sharon Calaman, Jennifer K. O'Toole
Publikováno v:
MedEdPORTAL, Vol 18 (2022)
Introduction Patient and family-centered rounds (PFCRs) are an important element of family-centered care often used in the inpatient pediatric setting. However, techniques and best practices vary, and faculty, trainees, nurses, and advanced care prov
Externí odkaz:
https://doaj.org/article/6dd3aa0a884c428f8586503156cf24b2
Autor:
Vitor Mendes, Simon R. Green, Joanna C. Evans, Jeannine Hess, Michal Blaszczyk, Christina Spry, Owain Bryant, James Cory-Wright, Daniel S-H. Chan, Pedro H. M. Torres, Zhe Wang, Navid Nahiyaan, Sandra O’Neill, Sebastian Damerow, John Post, Tracy Bayliss, Sasha L. Lynch, Anthony G. Coyne, Peter C. Ray, Chris Abell, Kyu Y. Rhee, Helena I. M. Boshoff, Clifton E. Barry, Valerie Mizrahi, Paul G. Wyatt, Tom L. Blundell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The bifunctional enzyme CoaBC catalyses the second and third step in the Coenzyme A (CoA) biosynthesis pathway and is of interest as a M. tuberculosis drug target. Here, the authors present the full-length crystal structure of Mycobacterium smegmatis
Externí odkaz:
https://doaj.org/article/dfbd7ac1fa2f42d49910fcdc7940c42e
Autor:
Stephanus T. Malherbe, Ray Y. Chen, Patrick Dupont, Ilse Kant, Magdalena Kriel, André G. Loxton, Bronwyn Smith, Caroline G. G. Beltran, Susan van Zyl, Shirely McAnda, Charmaine Abrahams, Elizna Maasdorp, Alex Doruyter, Laura E. Via, Clifton E. Barry, David Alland, Stephanie Griffith- Richards, Annare Ellman, Thomas Peppard, John Belisle, Gerard Tromp, Katharina Ronacher, James M. Warwick, Jill Winter, Gerhard Walzl
Publikováno v:
EJNMMI Research, Vol 10, Iss 1, Pp 1-15 (2020)
Abstract Background There is a growing interest in the use of F-18 FDG PET-CT to monitor tuberculosis (TB) treatment response. Tuberculosis lung lesions are often complex and diffuse, with dynamic changes during treatment and persisting metabolic act
Externí odkaz:
https://doaj.org/article/5d6e9e74073f4ab0a71f8f008e07ff38