Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Clifford W. Sachs"'
Publikováno v:
Biochemical Pharmacology. 58:1587-1592
To determine whether individual protein kinase C (PKC) isozymes differentially phosphorylate sites in the linker region of human P-glycoprotein (P-gp), we used a synthetic peptide substrate, PG-2, exactly corresponding to amino acid residues spanning
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e068776d8e9577150a1cecfba85d82e4
https://doi.org/10.1016/s0006-2952(99)00240-3
https://doi.org/10.1016/s0006-2952(99)00240-3
Publikováno v:
The Oncologist. 1:261-268
The multidrug resistant (MDR) phenotype is a well-studied subject that has been recognized as a determinant underlying specific types of drug resistance in human cancer. Although it is clear that the P-glycoprotein plays a major role in MDR, it is no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30ecfd52b2c410227babdef127fe2ebb
https://doi.org/10.1634/theoncologist.1-4-261
https://doi.org/10.1634/theoncologist.1-4-261
Publikováno v:
STEM CELLS. 14:47-55
The multidrug resistant (MDR) phenotype is a well-studied subject that has been recognized as a determinant underlying specific types of drug resistance in human cancer. Although it is clear that the P-glycoprotein plays a major role in MDR, it is no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaf8af3b99b0c5f213dc254823c0eeb3
https://doi.org/10.1002/stem.140047
https://doi.org/10.1002/stem.140047
Publikováno v:
Journal of Biological Chemistry. 270:22859-22865
Prenylcysteine methyl esters that represent the C-terminal structures of prenylated proteins demonstrate specific substrate-like interactions with P-glycoprotein (Zhang, L., Sachs, C. W., Fine, R. L., and Casey, P. J. (1994) J. Biol. Chem. 269, 15973
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57e45201e7bfa86b7c5277a4d536f278
https://doi.org/10.1074/jbc.270.39.22859
https://doi.org/10.1074/jbc.270.39.22859
Autor:
Yusuf A. Hannun, Gerard C. Blobe, Robert L. Fine, Wasiuddin A. Khan, Doriano Fabbro, Clifford W. Sachs, Lina M. Obeid, William C. Wetsel, S Stabel
Publikováno v:
Journal of Biological Chemistry. 268:658-664
The multidrug resistance (MDR) phenotype induces cross-resistance to many chemotherapeutic agents in cancer cells. Protein kinase C (PKC) has been implicated in the regulation of the MDR phenotype. In order to determine the role of specific PKC isoen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e9f5d2e3cb763ee44067da559f67e22
https://doi.org/10.1016/s0021-9258(18)54202-2
https://doi.org/10.1016/s0021-9258(18)54202-2
Publikováno v:
American Review of Respiratory Disease. 141:1249-1255
Several lines of evidence indicate that neutrophil elastase and oxidants secreted by phagocytic inflammatory cells play key roles in the development of centrilobular emphysema. A recent report suggests that ethanol consumption may have a protective r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45139decb7af6352ecd7baa5e7f5f829
https://doi.org/10.1164/ajrccm/141.5_pt_1.1249
https://doi.org/10.1164/ajrccm/141.5_pt_1.1249
Autor:
Robert M. Bell, Ahmad R. Safa, Clifford W. Sachs, Frank I. Carroll, Ballas Lm, Carson R. Loomis, Fine Rl, Lewin Ah, S W Mascarella
Publikováno v:
Biochemical pharmacology. 52(4)
To investigate the role of protein kinase C (PKC) in the regulation of multidrug resistance and P-glycoprotein (P-gp) phosphorylation, the natural isomer of sphingosine (SPH), D-erythro sphingosine (De SPH), and its three unnatural stereoisomers were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51461ec1658aa8c7e8ca509cca2140cf
https://pubmed.ncbi.nlm.nih.gov/8759033
https://pubmed.ncbi.nlm.nih.gov/8759033
Publikováno v:
The Journal of biological chemistry. 270(44)
Safingol is a lysosphingolipid protein kinase C (PKC) inhibitor that competitively interacts at the regulatory phorbol binding domain of PKC. We investigated the effects of safingol on antineoplastic drug sensitivity and PKC activity of MCF-7 tumor c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::693daf9c0388e4e92a88e8ff37201775
https://pubmed.ncbi.nlm.nih.gov/7592889
https://pubmed.ncbi.nlm.nih.gov/7592889