Výsledky vyhledávání - "Clifford Snapper"

Utilization of distinct antigen-presenting cells for induction of CD4+ T cell-dependent humoral immunity in response to an intact bacterium versus soluble conjugate vaccine (APP3P.105)

Autor: SWAGATA KAR, Clifford Snapper

Publikováno v: The Journal of Immunology. 194:113.6-113.6

We hypothesized that CD4+ T cell-dependent polysaccharide (PS)- and protein-specific IgG responses to intact bacteria versus soluble PS-protein conjugates involve utilization of distinct APC. Confocal microscopy demonstrated that intact Streptococcus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f25c426338fe1a5155584f58af20f53
https://doi.org/10.4049/jimmunol.194.supp.113.6

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Pneumococcal choline-binding proteins contain an activity that mediates Streptococcus pneumoniae-induced immunosuppression (IRC8P.478)

Autor: Saumyaa Saumyaa, Jesus Colino, Clifford Snapper

Publikováno v: The Journal of Immunology. 192:190.6-190.6

We previously demonstrated that intact, inactivated Streptococcus pneumoniae (strain R36A) inhibits murine IgG, T follicular helper, germinal center and plasma cell responses to co-immunized chicken ovalbumin (cOVA), whereas intact, inactivated Strep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::402f9e266fd4fec484ba34883759615f
https://doi.org/10.4049/jimmunol.192.supp.190.6

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Fc receptor-targeted vaccines: an adjuvant-independent approach for mucosal vaccination against intracellular and extracellular mucosal pathogens (P4290)

Autor: Edmund Gosselin, Constantine Bitsaktsis, Bibiana Iglesias, Giang Pham, James Drake, Clifford Snapper, Brian Franz

Publikováno v: The Journal of Immunology. 190:54.14-54.14

We previously demonstrated that immunization with inactivated Francisella tularensis, a Category A intracellular mucosal pathogen, combined with anti-F. tularensis mAb, enhances protection against F. tularensis challenge. We thus sought to determine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da7b99192b3e994b22ea1b39d5ba607c
https://doi.org/10.4049/jimmunol.190.supp.54.14

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Non-covalent association of protein and capsular polysaccharide on bacteria-sized latex beads as a model for polysaccharide-specific humoral immunity to intact Gram-positive extracellular bacteria (P3083)

Autor: Jesus Colino, Leah Duke, Clifford Snapper

Publikováno v: The Journal of Immunology. 190:125.17-125.17

Intact Streptococcus pneumoniae, expressing type 14 capsular polysaccharide (PPS14) and type 3 Streptococcus agalactiae containing a PPS14 core capsule identical to PPS14, exhibit non-covalent associations of PPS14 and bacterial proteins, in contrast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2987c952cd276ac28e383e534672b6cf
https://doi.org/10.4049/jimmunol.190.supp.125.17

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Inflammatory monocytes are critical for induction of a polysaccharide-specific antibody response to an intact bacterium (P3046)

Autor: Quanyi Chen, Clifford Snapper

Publikováno v: The Journal of Immunology. 190:125.1-125.1

Although inflammatory monocytes (IM) [CD11b+Ly6Chi] play important roles in cell-mediated host protection against intracellular pathogens, their impact on humoral immune responses to extracellular bacteria are unknown. IM, localized largely in the sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a30fd0ac8c65859026318cd29164b715
https://doi.org/10.4049/jimmunol.190.supp.125.1

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Regulation of T-cell dependent IgG response to soluble protein antigens in the presence and absence of intact bacteria (43.9)

Autor: Saumyaa Saumyaa, Swadhinya Arjunaraja, Raul Torres, Clifford Snapper

Publikováno v: The Journal of Immunology. 188:43.9-43.9

During bacterial infections the immune system encounters Ags associated with the intact bacterium simultaneously with those that are released in soluble form, although the immunologic consequences of this on IgG responses to the latter are unknown. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d20e630593b376399c3e6c2a3e1d0079
https://doi.org/10.4049/jimmunol.188.supp.43.9

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Structurally identical capsular polysaccharide expressed by intact group B Streptococcus versus Streptococcus pneumoniae elicits distinct murine polysaccharide-specific IgG responses in vivo (43.10)

Autor: Swadhinya Arjunaraja, Lawrence Paoletti, Clifford Snapper

Publikováno v: The Journal of Immunology. 188:43.10-43.10

Our previous studies using intact Streptococcus pneumoniae type 14 (Pn14) (Gram-positive) and Neisseria meningitidis (Gram-negative) indicated distinct differences in the regulation of the associated polysaccharide (PS)-specific IgG responses. In lig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::346d8f54e72ba3fde8debd57819f034f
https://doi.org/10.4049/jimmunol.188.supp.43.10

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Dendritic cell derived exosomes express a Streptococcus pneumoniae capsular polysaccharide type 14 cross-reactive antigen that induces protective immunoglobulin responses against pneumococcal infection in mice (43.10)

Autor: Jesus Colino, Clifford Snapper

Publikováno v: The Journal of Immunology. 178:S38-S38

Exosomes activate T cells in vivo, but whether exosomes are able to induce humoral immune responses is still unknown. We found that dendritic cells, but not other immune cells, constitutively release an exosome-associated glycoconjugate that is cross

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ccc50a4bc6a8f6726dc5b8f59e2e6fd5
https://doi.org/10.4049/jimmunol.178.supp.43.10

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