Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Clifford Sachs"'
Publikováno v:
Pharmaceuticals, Vol 17, Iss 7, p 875 (2024)
The unintended modulation of nuclear receptor (NR) activity by drugs can lead to toxicities amongst the endocrine, gastrointestinal, hepatic cardiovascular, and central nervous systems. While secondary pharmacology screening assays include NRs, safet
Externí odkaz:
https://doaj.org/article/a1d6f1b2234d4e938197f844f1ec0caa
Publikováno v:
Toxics, Vol 11, Iss 10, p 875 (2023)
The process of discovering small molecule drugs involves screening numerous compounds and optimizing the most promising ones, both in vitro and in vivo. However, approximately 90% of these optimized candidates fail during trials due to unexpected tox
Externí odkaz:
https://doaj.org/article/7a4e7dc8155e495d825041b7dd285ccc
Autor:
Carrie Brodmerkel, Charles Pendley, Mary Ann Mascelli, Gopi Shankar, Jacqueline Benson, Honghui Zhou, Clifford Sachs, George Treacy
Publikováno v:
Nature Biotechnology. 29:615-624
Preclinical and clinical studies conducted in the mid-1990s reported strong association and causality between the T-cell helper (T(H)) 1 inductor cytokine interleukin (IL)-12 and numerous immune-mediated disorders, which spurred the development of th
Autor:
Michael Oberst, Kim Rosenthal, James Hair, Catherine Auge, Srinath Kasturirangan, Yanan Zheng, Daniel Freeman, Srinivas Mamidi, Shino Hanabuchi, Francis Neal, Amanda Watkins, Clifford Sachs, Raymond Rothstein, Scott A. Hammond, James Moynihan
Publikováno v:
Cancer Research. 78:2775-2775
Targeted immunotherapy utilizing agonist antibodies (Ab) to OX40 shows great promise in preclinical mouse models alone or in combination with various therapies including PD1/PD-L1 antagonist Abs. Ab-mediated signaling through OX40 requires higher-ord
Autor:
George Treacy, Clifford Sachs, Pauline L. Martin, Satoru Oneda, Noritaka Imai, Hideshi Tsusaki, Qun Jiao
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 89:351-363
BACKGROUND: Ustekinumab is a human monoclonal antibody that binds to the p40 subunit of interleukin (IL) 12 and IL-23 and inhibits their pharmacological activity. To evaluate potential effects of ustekinumab treatment during pregnancy, developmental
Autor:
Suezanne Parker, Rafael Ponce, Ronald Steigerwalt, John L. Vahle, David N. Hovland, Brian Short, Gregory L. Finch, Inge A Ivens, Marque Todd, Clifford Sachs, Shawn M. Heidel
Publikováno v:
Toxicologic pathology. 38(4)
An important safety consideration for developing new therapeutics is assessing the potential that the therapy will increase the risk of cancer. For biotherapeutics, traditional two-year rodent bioassays are often not scientifically applicable or feas
Publikováno v:
Pharmaceutical Sciences Encyclopedia ISBN: 9780470571224
Pharmaceutical Sciences Encyclopedia
Pharmaceutical Sciences Encyclopedia
A number of immunomodulatory biopharmaceuticals (IMBPs), such as peptides, recombinant proteins, and monoclonal antibodies, have been approved or are currently in development to treat chronic inflamatory diseases. IMBPs by virtue of their intended ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af912f5609b92a835074999b49d37716
https://doi.org/10.1002/9780470571224.pse186
https://doi.org/10.1002/9780470571224.pse186
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology.
BACKGROUND: CNTO 530is a biopharmaceutical consisting of a novel peptide that mimics the actions of erythropoietin, fused to the Fc fragment of human IgG4. Pharmacokinetic and pharmacodynamic studies showed that CNTO 530 produced sustained increases
Autor:
Miles Cloyd, Darren Mathews, Clifford Sachs, William S. Lynn, James C. Wallwork, Aubrey Thompson
Publikováno v:
Archives of environmental health. 44(5)
Following injury or activation in some immune cell lines, elevation of intracellular Ca2+ concentration (Cai2+) is an early and major event that precedes cell death. Agents shown to elevate Cai2+ and to result subsequently in the death of some cells