Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Clifford R. Elcombe"'
Autor:
Quan Shi, Juan-Carlos Carrillo, Michael G. Penman, Jason Manton, Elena Fioravanzo, Robert H. Powrie, Clifford R. Elcombe, Tilly Borsboom-Patel, Yuan Tian, Hua Shen, Peter J. Boogaard
Publikováno v:
Chemical Research in Toxicology 35 (2022) 8
Chemical Research in Toxicology, 35(8), 1383-1392
Chemical Research in Toxicology, 35(8), 1383-1392
To reduce the number of animals and studies needed to fulfill the information requirements as required by Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) (EC no. 1907/2006), a read-across approach was used to support appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::578f5d7d8706476f04f9ccfc2df7e09a
https://doi.org/10.1021/acs.chemrestox.2c00089
https://doi.org/10.1021/acs.chemrestox.2c00089
Publikováno v:
Carcinogenicity ISBN: 9781003067641
Carcinogenicity
Carcinogenicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d56f62749ca91ec6a76aedd77a9fe9b
https://doi.org/10.1201/9781003067641-14
https://doi.org/10.1201/9781003067641-14
Autor:
Iain R. Macpherson, Leslie Samuel, Eddie Doyle, Yang Liu, Matteo Convertino, Anna Barnett, Clifford R. Elcombe, Geary W. Olsen, Thomas J. Evans, Timothy R. Church
Publikováno v:
Toxicological Sciences
A phase 1 dose-escalation trial assessed the chemotherapeutic potential of ammonium perfluorooctanoate (APFO). Forty-nine primarily solid-tumor cancer patients who failed standard therapy received weekly APFO doses (50–1200 mg) for 6 weeks. Clinica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53bfe19b2aca033163de3a17ef4d8aab
https://doi.org/10.1093/toxsci/kfy035
https://doi.org/10.1093/toxsci/kfy035
Autor:
Heike Marxfeld, Silke Treumann, Naveed Honarvar, Roland Buesen, Lynsey R. Chatham, Christiane Wiemann, Barbara M. Elcombe, Hongbing Wang, Clifford R. Elcombe, Audrey Vardy, Sibylle Groeters, Manuela Goettel, Brian G. Lake, Linhao Li
Publikováno v:
Toxicology. 426
In a 2-year study the herbicide metazachlor (BAS 479H) was shown to significantly increase the incidence of liver tumours in female Wistar rats at a dietary level of 8000 ppm. As metazachlor is not a genotoxic agent, a series of in vivo and in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b2745416007484b893b5ee4e3b3ebbd
https://pubmed.ncbi.nlm.nih.gov/31465819
https://pubmed.ncbi.nlm.nih.gov/31465819
Autor:
Lynsey R. Chatham, Clifford R. Elcombe, Corinne Haines, Audrey Vardy, John R. Foster, Brian G. Lake
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 49(2)
The hepatic and thyroid gland effects of the constitutive androstane receptor (CAR) activator sodium phenobarbital (NaPB) and the pregnane X receptor (PXR) activator pregnenolone-16α-carbonitrile (PCN) were examined in male Sprague-Dawley wild-type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c17a881f28707a1b4e27a685f4481a
https://pubmed.ncbi.nlm.nih.gov/29424600
https://pubmed.ncbi.nlm.nih.gov/29424600
Autor:
Audrey Vardy, Lynsey R. Chatham, Larry G. Higgins, Barbara M. Elcombe, Corinne Haines, Brian G. Lake, Clifford R. Elcombe
Publikováno v:
Toxicology.
Phenobarbital (PB), a constitutive androstane receptor (CAR) activator, produces liver tumours in rodents by a mitogenic mode of action involving CAR activation. In this study, the hepatic effects of sodium phenobarbital (NaPB) were compared in male
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d207a8fcc7fb97caaa45b61016357dcb
https://pubmed.ncbi.nlm.nih.gov/29425889
https://pubmed.ncbi.nlm.nih.gov/29425889
Autor:
Corinne Haines, John R. Foster, Lynsey R. Chatham, Clifford R. Elcombe, Brian G. Lake, Audrey Vardy
Publikováno v:
Toxicology.
A number of chemicals produce liver and thyroid gland tumours in rodents by nongenotoxic modes of action (MOAs). In this study the hepatic and thyroid gland effects of the constitutive androstane receptor (CAR) activator sodium phenobarbital (NaPB) w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c8cfab79917009dee276b6f2b23c1ed
https://pubmed.ncbi.nlm.nih.gov/29548889
https://pubmed.ncbi.nlm.nih.gov/29548889
Autor:
Philippe Couttet, Jonathan G. Moggs, Valerie Dubost, Antonio Vitobello, Diethilde Theil, Bettina Grasl-Kraupp, Salah-Dine Chibout, Heidrun Ellinger-Ziegelbauer, Hisanori Hara, Colin J. Henderson, Nico Scheer, Rémi Terranova, Harri Lempiäinen, Frank Picard, Michael Schwarz, Clifford R. Elcombe, Pierre Moulin, John P. Thomson, Arne Müller, Olivier Grenet, C. Roland Wolf, Richard R. Meehan, Raphaëlle Luisier, Miriam Geissler, Nina Scherbichler, Albert Braeuning
Publikováno v:
Toxicological Sciences. 139:501-511
The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are closely related nuclear receptors involved in drug metabolism and play important roles in the mechanism of phenobarbital (PB)-induced rodent nongenotoxic hepatocarcinoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0989ade39f36bbc0e35a0230e8c8d048
https://doi.org/10.1093/toxsci/kfu038
https://doi.org/10.1093/toxsci/kfu038
Autor:
Shu-Ching Chang, Patricia E. Noker, John L. Butenhoff, Clifford R. Elcombe, Barbara M. Elcombe, David J. Ehresman, John R. Foster
Publikováno v:
Toxicology. 293:30-40
In a prior 28-day dietary study in rats with 20 and 100 ppm K⁺ PFOS, activation of PPARα and CAR/PXR were concluded to be etiological factors in K⁺ PFOS-induced hepatomegaly and hepatic tumorigenesis. The objective of this study was to evaluate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a8a85ee1ff82822e3ba48d132d84b78
https://doi.org/10.1016/j.tox.2011.12.015
https://doi.org/10.1016/j.tox.2011.12.015
Autor:
John L. Butenhoff, David J. Ehresman, John R. Foster, Clifford R. Elcombe, Shu-Ching Chang, Barbara M. Elcombe
Publikováno v:
Toxicology. 293:16-29
The present study investigated the potential role for activation of PPARα and CAR/PXR by potassium PFOS (K⁺ PFOS) with respect to the etiology of hepatic hypertrophy and hepatocellular adenoma in rats. Male Sprague-Dawley rats were fed K⁺ PFOS (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc17053e85c214cb057377adad22bbe5
https://doi.org/10.1016/j.tox.2011.12.014
https://doi.org/10.1016/j.tox.2011.12.014