Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Clifford P Brangwynne"'
Autor:
Yaojun Zhang, Andrew GT Pyo, Ross Kliegman, Yoyo Jiang, Clifford P Brangwynne, Howard A Stone, Ned S Wingreen
Publikováno v:
eLife, Vol 12 (2024)
A hallmark of biomolecular condensates formed via liquid-liquid phase separation is that they dynamically exchange material with their surroundings, and this process can be crucial to condensate function. Intuitively, the rate of exchange can be limi
Externí odkaz:
https://doaj.org/article/595acaa4e15b44639eb721872aafc37b
Autor:
Amy R Strom, Ronald J Biggs, Edward J Banigan, Xiaotao Wang, Katherine Chiu, Cameron Herman, Jimena Collado, Feng Yue, Joan C Ritland Politz, Leah J Tait, David Scalzo, Agnes Telling, Mark Groudine, Clifford P Brangwynne, John F Marko, Andrew D Stephens
Publikováno v:
eLife, Vol 10 (2021)
Chromatin, which consists of DNA and associated proteins, contains genetic information and is a mechanical component of the nucleus. Heterochromatic histone methylation controls nucleus and chromosome stiffness, but the contribution of heterochromati
Externí odkaz:
https://doaj.org/article/7e515497572943718908128a28128049
Autor:
David W Sanders, Chanelle C Jumper, Paul J Ackerman, Dan Bracha, Anita Donlic, Hahn Kim, Devin Kenney, Ivan Castello-Serrano, Saori Suzuki, Tomokazu Tamura, Alexander H Tavares, Mohsan Saeed, Alex S Holehouse, Alexander Ploss, Ilya Levental, Florian Douam, Robert F Padera, Bruce D Levy, Clifford P Brangwynne
Publikováno v:
eLife, Vol 10 (2021)
Many enveloped viruses induce multinucleated cells (syncytia), reflective of membrane fusion events caused by the same machinery that underlies viral entry. These syncytia are thought to facilitate replication and evasion of the host immune response.
Externí odkaz:
https://doaj.org/article/a25f5d2a1fee480aabdd9b8491fcd288
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Cell migration through small constrictions during cancer metastasis requires significant deformation of the nucleus, with associated mechanical stress on the nuclear lamina and chromatin. However, how mechanical deformation impacts various s
Externí odkaz:
https://doaj.org/article/6c26cfee30884116b1924f3078ecc60b
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Phase separation has been suggested as a mechanism for heterochromatin formation through condensation of heterochromatin-associated factors. Here the authors show Polycomb complex PRC1 forms condensates on chromatin. Using optogenetic tools they nucl
Externí odkaz:
https://doaj.org/article/7f452b896dc54166b408650ee691f243
Publikováno v:
APL Bioengineering, Vol 6, Iss 2, Pp 021503-021503-10 (2022)
The cell nucleus can be thought of as a complex, dynamic, living material, which functions to organize and protect the genome and coordinate gene expression. These functions are achieved via intricate mechanical and biochemical interactions among its
Externí odkaz:
https://doaj.org/article/53b6f797d32a4151bce512fb8ccc0c19
Autor:
Nicholas Treen, Shunsuke F. Shimobayashi, Jorine Eeftens, Clifford P. Brangwynne, Michael Levine
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
While recent studies suggest that transcriptional activators form condensates at active loci, less is known about the distribution of repressor proteins. Here, the authors develop an expression assay in living Ciona embryos and visualize puncta of He
Externí odkaz:
https://doaj.org/article/29f07ca6d62e4813bc5ededc4c809dcc
Publikováno v:
Genes & Development. 37:80-85
Zygotic genome activation has been extensively studied in a variety of systems including flies, frogs, and mammals. However, there is comparatively little known about the precise timings of gene induction during the earliest phases of embryogenesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea3103e5e7212fb3eb0e131a22151efd
https://doi.org/10.1101/gad.350164.122
https://doi.org/10.1101/gad.350164.122
Autor:
Bernardo Gouveia, Yoonji Kim, Joshua W. Shaevitz, Sabine Petry, Howard A. Stone, Clifford P. Brangwynne
Publikováno v:
Nature. 609:255-264
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1997940704f41cd07ca48db62946742
https://doi.org/10.1038/s41586-022-05138-6
https://doi.org/10.1038/s41586-022-05138-6
Autor:
Ushnish Rana, Ke Xu, Amal Narayanan, Mackenzie T. Walls, Athanassios Z. Panagiotopoulos, José L. Avalos, Clifford P. Brangwynne
Endogenous biomolecular condensates, comprised of a multitude of proteins and RNAs, can organize into multiphasic structures, with compositionally-distinct phases. This multiphasic organization is generally understood to be critical for facilitating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6559dab3db0715de75c7f8e2a6eb5127
https://doi.org/10.1101/2023.03.11.532188
https://doi.org/10.1101/2023.03.11.532188
