Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Clifford Longley"'
Autor:
Madhukumar Venkatesh, Sean Kim, Gary L. Goldberg, Sridhar Mani, Michael Sinz, Kathleen D. Whitney, Divya Gupta, Clifford Longley, Hongwei Wang
Publikováno v:
Clinical Cancer Research. 14:5332-5340
Purpose: We examined the presence of the pregnane X receptor (PXR) and its effects on ovarian cancer cells after activation by its cognate ligand. Experimental Design: SKOV-3 and OVCAR-8 ovarian carcinoma cells were analyzed for expression of PXR by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::197445ad37589df4a34d8f19d9387d70
https://doi.org/10.1158/1078-0432.ccr-08-1033
https://doi.org/10.1158/1078-0432.ccr-08-1033
Autor:
Yoany Lozanguiez, Hong Zhao, Prasanna Reddy, Ying Gao, Clifford Longley, Anthony Martinez, Dechun Wu, Belen Rubio, Prakash Sai, Puja Sapra, Lee M. Greenberger, Ivan D. Horak
Publikováno v:
Bioconjugate Chemistry. 19:849-859
CPT-11, also known as irinotecan, is a prodrug that is approved for the treatment of advanced colorectal cancer. The active metabolite of CPT-11, SN38 (7-ethyl-10-hydroxy-camptothecin), has 100- to 1000-fold more potent cytotoxic activity in tissue c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::509b0527d67547c05f62383a090e7cdf
https://doi.org/10.1021/bc700333s
https://doi.org/10.1021/bc700333s
Autor:
Clifford Longley
Investigating a burglary at an English country house, DI Robbie Peele comes face to face with some of the most mysterious objects in world archaeology, disks similar to the Phaestos Disk - and with a Middle Eastern terrorist cell determined to steal
Autor:
Mary Mehlig, Clifford Longley, Ping Peng, Virna Borowski, Gerrit Borchard, Cy A. Stein, Jing Xia, Prasanna Reddy, Luba Benimetskaya, Hong Zhao, Jack M. Lipman, Yue Zhang
Publikováno v:
Journal of Controlled Release. 119:143-152
In order to overcome the problems of enzymatic degradation and short plasma half life, which can limit the delivery of antisense oligonucleotides, and the potential immuno-stimulatory effects of CpG motifs, we utilized a polyethylene glycol (PEG) tec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a06fb8be4f949a9346766814ae01ed
https://doi.org/10.1016/j.jconrel.2006.12.021
https://doi.org/10.1016/j.jconrel.2006.12.021
Autor:
Karen Yang, David J. FitzGerald, Gerald Petti, Raffit Hassan, Deshan Yu, Dechun Wu, Hong Zhao, Zhenfan Zhang, Robert J. Kreitman, Amartya Basu, Ahsen Janjua, Qing-cheng Wang, Zhihua Zhang, Laiman Xiang, Mitchell Ho, Jun Liu, Xiguang Li, Clifford Longley, John Zhou, David Filpula, Richard Beers, Ira Pastan, Maoliang Wang, Ping Peng
Publikováno v:
Bioconjugate Chemistry. 18:773-784
Recombinant immunotoxins exhibit targeting and cytotoxic functions needed for cell-specific destruction. However, antitumor efficacy, safety, and pharmacokinetics of these therapeutics might be improved by further macromolecular engineering. SS1P is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e0ceabad0d54d1425c3f733df4fb515
https://doi.org/10.1021/bc060314x
https://doi.org/10.1021/bc060314x
Autor:
Zhihua Zhang, Eun Jang, Hsien-Ching Liu, Prakash Sai, Manickam Viswanathan, Gerald Petti, Clifford Longley, Xiguang Li, Virna Borowski, Karen Yang, Amartya Basu, Ping Peng, Stephen K. Youngster, Sam Liu, David Filpula, Maoliang Wang, Thomas Palm, Mary Mehlig, Hong Zhao, Lisa Hwang, Jack Hua, Yue Zhang
Publikováno v:
Bioconjugate Chemistry. 17:1447-1459
Arginine is an important metabolite in the normal function of several biological systems, and arginine deprivation has been investigated in animal models and human clinical trials for its effects on inhibition of tumor growth, angiogenesis, or nitric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f414284390dfc691d44aa7d7bb546ed
https://doi.org/10.1021/bc060198y
https://doi.org/10.1021/bc060198y
Autor:
Jing Xia, Clifford Longley, Yun H. Choe, Charles D. Conover, Qiuxia Zhao, Shuiyun Guan, Richard B. Greenwald, Hong Zhao
Publikováno v:
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics. 14:455-468
6-Mercaptopurine (6-MP) is an orally administered, water-insoluble purine analog that is effective against acute lymphatic leukemia. Oral absorption of 6-MP, however, is quite erratic, with only 16-50% of the administered dose reaching the blood. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e767024f29b977de5f73e17d0962657
https://doi.org/10.3727/0965040041791446
https://doi.org/10.3727/0965040041791446
Publikováno v:
Bioconjugate Chemistry. 14:661-666
This paper reports on the synthesis, safety, and efficacy of a series of water-soluble derivatives of poly(ethylene glycol) (PEG)-conjugated amphotericin B (AmB). PEG 40 000 attached to the sugar amino group of AmB via labile carbamate and carbonate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59774e3a9da645781d0cdfb861db18ac
https://doi.org/10.1021/bc0256594
https://doi.org/10.1021/bc0256594
Autor:
Lee M. Greenberger, Clifford Longley, Puja Sapra, Jennifer Malaby, Hong Zhao, Ivan Horak, Patricia Kraft, Mary Mehlig
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 14(6)
Purpose: Clinical development of SN38, the active metabolite of camptothecin-11 (CPT-11), has been hampered due to its poor solubility. We have developed a novel polymer-drug conjugate, EZN-2208, made by linking SN38 with a multiarm polyethylene glyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2115488d00fb12c8ffbc106aa285d0f0
https://pubmed.ncbi.nlm.nih.gov/18347192
https://pubmed.ncbi.nlm.nih.gov/18347192
Autor:
Ping Peng, Manickam Viswanathan, Amartya Basu, Ahsen Janjua, Xiguang Li, Dechun Wu, Hong Zhao, Zhihua Zhang, John Zhou, Jun Liu, Magda Mendez, Maoliang Wang, Zhenfan Zhang, Jack Hua, Karen Yang, David Filpula, Gerald Petti, Ramesh Chintala, Virna Borowski, Clifford Longley, Thomas Palm, Mary Mehlig, Sam Liu, Ming-Ching Hsieh
Publikováno v:
Bioconjugate chemistry. 17(3)
Recombinant interferon-beta-1b (IFN-beta-1b) is used clinically in the treatment of multiple sclerosis. In common with many biological ligands, IFN-beta-1b exhibits a relatively short serum half-life, and bioavailability may be further diminished by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::632b990fb39c1979b6660e82ee0611b7
https://pubmed.ncbi.nlm.nih.gov/16704199
https://pubmed.ncbi.nlm.nih.gov/16704199