Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Clifford Liongue"'
Publikováno v:
Journal of Innate Immunity, Pp 1-1 (2024)
Introduction: Signal transducer and activator of transcription (STAT) 3 is extensively involved in the development, homeostasis, and function of immune cells, with STAT3 disruption associated with human immune-related disorders. The roles ascribed to
Externí odkaz:
https://doaj.org/article/52b8ef9053994760a0505d13c7c584fc
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2977 (2024)
The Janus kinase (JAK) family is a small group of protein tyrosine kinases that represent a central component of intracellular signaling downstream from a myriad of cytokine receptors. The JAK3 family member performs a particularly important role in
Externí odkaz:
https://doaj.org/article/edd979fbe39d4003bffad918b5dadfda
Autor:
Clifford Liongue, Alister C. Ward
Publikováno v:
Cancers, Vol 16, Iss 2, p 313 (2024)
Myeloproliferative neoplasms (MPNs) are hematopoietic diseases characterized by the clonal expansion of single or multiple lineages of differentiated myeloid cells that accumulate in the blood and bone marrow. MPNs are grouped into distinct categorie
Externí odkaz:
https://doaj.org/article/84bd6de8d46c450fbc845ed59c6bc3d5
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 389 (2023)
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor activated canonically by numerous cytokines and other factors, with significant roles in immunity, immune diseases, and cancer. It has also been implicated in severa
Externí odkaz:
https://doaj.org/article/f93115f58581479fa4ce817ab1dd4916
Publikováno v:
Biomedicines, Vol 12, Iss 1, p 45 (2023)
The signal transducer and activator of transcription (STAT) family of proteins has been demonstrated to perform pivotal roles downstream of a myriad of cytokines, particularly those that control immune cell production and function. This is highlighte
Externí odkaz:
https://doaj.org/article/18c29329811f4f438c0570e63e161ec5
Autor:
Saeed Maymand, Asha L. Lakkavaram, Wasan Naser, Parisa Rasighaemi, Daniel Dlugolenski, Clifford Liongue, John Stambas, Tania F. de Koning-Ward, Alister C. Ward
Publikováno v:
Biomolecules, Vol 13, Iss 10, p 1510 (2023)
The cytokine-inducible SH2 domain-containing (CISH) protein was the first member of the suppressor of cytokine signaling (SOCS) family of negative feedback regulators discovered, being identified in vitro as an inducible inhibitor of erythropoietin (
Externí odkaz:
https://doaj.org/article/e419f84742744f50bc89c18b8ec24685
Autor:
Mohamed L. Sobah, Aimee C. Scott, Miranda Laird, Cassandra Koole, Clifford Liongue, Alister C. Ward
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionSuppressor of cytokine signaling 3 (SOCS3) is a critical component of the negative feedback regulation that controls signaling by cytokines and other factors thereby ensuring that important processes such as hematopoiesis and inflammation
Externí odkaz:
https://doaj.org/article/39779044a8b044bfb38719ceb50d6910
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
IntroductionThe granulocyte colony-stimulating factor receptor (G-CSFR), encoded by the CSF3R gene, is involved in the production and function of neutrophilic granulocytes. Somatic mutations in CSF3R leading to truncated G-CSFR forms are observed in
Externí odkaz:
https://doaj.org/article/97a8e211c6af4ea78514a7ce1874cbcd
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 28, Iss 8, p 187 (2023)
Background: Signal transducer and activator of transcription (STAT) proteins play key roles in development, growth, and homeostasis. These roles have principally been assigned to their “canonical” function as inducible transcriptional activators
Externí odkaz:
https://doaj.org/article/0e123a21fbda496f9e66fb57b99478e3
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-17 (2021)
Abstract STAT proteins represent an important family of evolutionarily conserved transcription factors that play key roles in diverse biological processes, notably including blood and immune cell development and function. Classically, STAT proteins h
Externí odkaz:
https://doaj.org/article/b77538a809cf432fa5e70a478f2244e6