Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Clifford E. Berkman"'
Autor:
Brenna C. McAllister, Nooshin Mesbahi, Esther E. Dodson, Sakinah Abdulsalam, Clifford E. Berkman, Leslie A. Caromile
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Giant cell tumor of bone (GCTB) is a rare bone tumor often necessitating surgical intervention, radiation therapy, or treatment with bisphosphonates or denosumab. 99mTc-MDP bone scintigraphy for GCTB has limited specificity, and the relatively high u
Externí odkaz:
https://doaj.org/article/7ed1d90cd17b4d1188e9552bc29a662d
Autor:
Michael D. Pun, Hsin-Hua Wu, Feyisola P. Olatunji, Britany N. Kesic, John W. Peters, Clifford E. Berkman
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1315-1319 (2022)
Histone deacetylases (HDACs) are a family of enzymes responsible for regulating DNA transcription by modulating its binding to histone proteins. HDACs are overexpressed in several types of cancers and are recognised as drug targets. Vorinostat, or su
Externí odkaz:
https://doaj.org/article/a9ccf5c5ec2d408eafe85ab37d1e230c
Autor:
Feyisola P. Olatunji, Michael Pun, Jacob W. Herman, Oscar Romero, Mitchell Maniatopoulos, Joseph D. Latoche, Robert A. Parise, Jianxia Guo, Jan H. Beumer, Carolyn J. Anderson, Clifford E. Berkman
Publikováno v:
Mol Cancer Ther
New targeted chemotherapeutics are urgently needed to minimize off-target toxicity and reduce the high-mortality rate associated with metastatic prostate cancer. Herein, we report on the modular synthesis, pharmacokinetics, and efficacy of two small-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d704048493ad988bca36828290750d
https://doi.org/10.1158/1535-7163.mct-22-0160
https://doi.org/10.1158/1535-7163.mct-22-0160
Autor:
Clifford E. Berkman, Carolyn J. Anderson, Jan H. Beumer, Jianxia Guo, Robert A. Parise, Joseph D. Latoche, Mitchell Maniatopoulos, Oscar Romero, Jacob W. Herman, Michael Pun, Feyisola P. Olatunji
Supplementary Data from Modular Smart Molecules for PSMA-Targeted Chemotherapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b2208a0a3a162c0934bede2fe5cdfa0
https://doi.org/10.1158/1535-7163.22523347
https://doi.org/10.1158/1535-7163.22523347
Autor:
Hsin-Hua Wu, Michael D. Pun, Courtney E. Wise, Bennett R. Streit, Florence Mus, Anna Berim, William M. Kincannon, Abdullah Islam, Sarah E. Partovi, David R. Gang, Jennifer L. DuBois, Carolyn E. Lubner, Clifford E. Berkman, B. Markus Lange, John W. Peters
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(36)
Mercaptoethane sulfonate or coenzyme M (CoM) is the smallest known organic cofactor and is most commonly associated with the methane-forming step in all methanogenic archaea but is also associated with the anaerobic oxidation of methane to CO 2 in an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff36da9d309f13c2282e97c1c5429a2
https://pubmed.ncbi.nlm.nih.gov/36037354
https://pubmed.ncbi.nlm.nih.gov/36037354
Publikováno v:
Chemical Research in Toxicology. 33:2455-2466
Studies with acetylcholinesterase (AChE) inhibited by organophosphorus (OP) compounds with two chiral centers can serve as models or surrogates for understanding the rate, orientation, and postinhibitory mechanisms by the nerve agent soman that posse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c1f1106e6289aefdf66c0c897a5efb8
https://doi.org/10.1021/acs.chemrestox.0c00236
https://doi.org/10.1021/acs.chemrestox.0c00236
Autor:
Mylan Panteah, Nooshin Mesbahi, Cresencia M Talley, Emily A Savoy, Leslie A. Caromile, Christine L Lovingier, Feyisola P. Olatunji, Clifford E. Berkman, Armina Abbasi
Publikováno v:
Bioconjug Chem
The tunable nature of phosphoramidate linkers enables broad applicability as pH-triggered controlled-release platforms, particularly in the context of antibody- and small-molecule-drug conjugates (ADCs and SMDCs), where there remains a need for new l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3781b88fee9ed1dda17e1139570cfe89
https://pubmed.ncbi.nlm.nih.gov/34699177
https://pubmed.ncbi.nlm.nih.gov/34699177
Publikováno v:
Bioorg Med Chem Lett
l-Dopa has continued to be a mainstay in the symptomatic treatment of Parkinson’s disease (PD). However, extensive peripheral metabolism, a short systemic circulation half-life and development of motor complications called dyskinesia prevents its l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7ea18d6d835f49d4758faed0ade6cdf
https://doi.org/10.1016/j.bmcl.2019.08.005
https://doi.org/10.1016/j.bmcl.2019.08.005
Autor:
Beatrice Langton-Webster, Charles M. Laymon, Brenda F. Kurland, Nathan Salamacha, Lora H. Rigatti, Hillarie P Windish, Jonathan J. Geruntho, Carolyn J. Anderson, Cindy J. Choy, Clifford E. Berkman, Ding Shen, Yijen L. Wu, Xiaoxi Ling, Joseph D. Latoche
Publikováno v:
Mol Imaging Biol
PURPOSE: Prostate-specific membrane antigen (PSMA) continues to be the hallmark biomarker for prostate cancer as it is expressed on nearly all prostatic tumors. In addition, increased PSMA expression correlates with castration resistance and progress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f788677b41dc085d9aab3ce9bce79ae
https://doi.org/10.1007/s11307-019-01404-8
https://doi.org/10.1007/s11307-019-01404-8
Publikováno v:
Spectrochim Acta A Mol Biomol Spectrosc
A unique reaction between thiols (RSH) and alkyl sulfonylbenzothiazole was discovered. This reaction was specific for thiols and produced a sulfinic acid (RSO(2)H) as the intermediate, which further triggered an intramolecular cyclization to release
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b3c7e324eb20d57aa498e2117f7eedd
https://europepmc.org/articles/PMC7736145/
https://europepmc.org/articles/PMC7736145/