Výsledky vyhledávání - "Clifford Dustin Rubinstein"

Akademický článek

Assessment of Mosaicism and Detection of Cryptic Alleles in CRISPR/Cas9-Engineered Neurofibromatosis Type 1 and TP53 Mutant Porcine Models Reveals Overlooked Challenges in Precision Modeling of Human Diseases

Autor: Clifford Dustin Rubinstein, Dalton T. McLean, Brent P. Lehman, Jennifer J. Meudt, Dominic T. Schomberg, Kathy J. Krentz, Jamie L. Reichert, Mark B. Meyer, Marie Adams, Charles M. Konsitzke, Dhanansayan Shanmuganayagam

Publikováno v: Frontiers in Genetics, Vol 12 (2021)

Genome editing in pigs has been made efficient, practical, and economically viable by the CRISPR/Cas9 platform, representing a promising new era in translational modeling of human disease for research and preclinical development of therapies and devi

Externí odkaz: https://doaj.org/article/c901f93349584b52870a52843c992889

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Generation of an Allelic Series at the Ahr Locus Using an Edited Recombinant Approach

Autor: Jeremiah S. Yee, Rachel H Wilson, Clifford Dustin Rubinstein, Nicholas A Goetz, Jessica C. Parrott, Manabu Nukaya, Susan M. Moran, E.W.N. Glover, Brenda L Rojas, Kathy J. Krentz, Christopher A. Bradfield, Yongna Xing, Patrick R. Carney

Publikováno v: Toxicol Sci

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor and a member of the PER-ARNT-SIM (PAS) superfamily of environmental sensors. The AHR is involved in a series of biological processes including adaptive metabolism of xenob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6495cb26c6b27a21188fb4bb35ec4db
https://pubmed.ncbi.nlm.nih.gov/33480436

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