Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Clifford D. Jones"'
Autor:
Caroline Phillips, Inder Bhamra, Catherine Eagle, Eimear Flanagan, Richard Armer, Clifford D. Jones, Matilda Bingham, Peter Calcraft, Alicia Edmenson Cook, Ben Thompson, Simon A. Woodcock
Publikováno v:
Cancer Research Communications. 2:914-928
Wnt signaling is implicated in the etiology of gastrointestinal tract cancers. Targeting Wnt signaling is challenging due to on-target toxicity concerns and lack of druggable pathway components. We describe the discovery and characterization of RXC00
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9bb9110f43725fa09f812b6af865ea2
https://doi.org/10.1158/2767-9764.crc-21-0095
https://doi.org/10.1158/2767-9764.crc-21-0095
Autor:
Simon A. Woodcock, Ben Thompson, Alicia Edmenson Cook, Peter Calcraft, Matilda Bingham, Clifford D. Jones, Richard Armer, Eimear Flanagan, Catherine Eagle, Inder Bhamra, Caroline Phillips
Supplementary Figure 1: Effect of RXC004 on gene expression, caspase activity and cell growth in colorectal and pancreatic cancer cell lines in vitro. Supplementary Figure 2: RXC004 effects on gene expression in in vivo xenograft tumor models. Supple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b6893e4d505480fc43f1898c349fe1e
https://doi.org/10.1158/2767-9764.22545548
https://doi.org/10.1158/2767-9764.22545548
Autor:
Simon A. Woodcock, Ben Thompson, Alicia Edmenson Cook, Peter Calcraft, Matilda Bingham, Clifford D. Jones, Richard Armer, Eimear Flanagan, Catherine Eagle, Inder Bhamra, Caroline Phillips
Wnt signaling is implicated in the etiology of gastrointestinal tract cancers. Targeting Wnt signaling is challenging due to on-target toxicity concerns and lack of druggable pathway components. We describe the discovery and characterization of RXC00
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9e1e0c142eeceed8c07581b97cf0c3
https://doi.org/10.1158/2767-9764.c.6550973.v1
https://doi.org/10.1158/2767-9764.c.6550973.v1
Autor:
Paul D. Smith, J. Elizabeth Pease, Sabina C. Cosulich, Iain Simpson, Richard A. Ward, Clifford D. Jones, Stephen E. Fawell, Mathew J. Garnett, Patricia Jaaks, Elizabeth A. Coker, Claire Rooney, Martine P. Roudier, Sophie E. Willis, Philip Hopcroft, Michael Tonge, Karen Roberts, Joanne Wilson, Aaron Smith, Nicola Lindsay, Francis D. Gibbons, Katarzyna Falenta, Sigourney Bell, Paul Farrington, Lyndsey Hanson, Pei Zhang, Oona Delpuech, Linda C. Sandin, David Robinson, Emma J. Davies, Vikki Flemington
Primers used for targeted gene profiling on selected RAS/MAPK pathway genes either on Fluidigm or by qRT-PCR on Roche Lightcycler 480
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24be1d38b84bbeb9fe19955e7de25d2b
https://doi.org/10.1158/1535-7163.22521541
https://doi.org/10.1158/1535-7163.22521541
Autor:
Paul D. Smith, J. Elizabeth Pease, Sabina C. Cosulich, Iain Simpson, Richard A. Ward, Clifford D. Jones, Stephen E. Fawell, Mathew J. Garnett, Patricia Jaaks, Elizabeth A. Coker, Claire Rooney, Martine P. Roudier, Sophie E. Willis, Philip Hopcroft, Michael Tonge, Karen Roberts, Joanne Wilson, Aaron Smith, Nicola Lindsay, Francis D. Gibbons, Katarzyna Falenta, Sigourney Bell, Paul Farrington, Lyndsey Hanson, Pei Zhang, Oona Delpuech, Linda C. Sandin, David Robinson, Emma J. Davies, Vikki Flemington
Supplementary Figure 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d8cb1ae292b59622591433bfe72565e
https://doi.org/10.1158/1535-7163.22521556
https://doi.org/10.1158/1535-7163.22521556
Autor:
Paul D. Smith, J. Elizabeth Pease, Sabina C. Cosulich, Iain Simpson, Richard A. Ward, Clifford D. Jones, Stephen E. Fawell, Mathew J. Garnett, Patricia Jaaks, Elizabeth A. Coker, Claire Rooney, Martine P. Roudier, Sophie E. Willis, Philip Hopcroft, Michael Tonge, Karen Roberts, Joanne Wilson, Aaron Smith, Nicola Lindsay, Francis D. Gibbons, Katarzyna Falenta, Sigourney Bell, Paul Farrington, Lyndsey Hanson, Pei Zhang, Oona Delpuech, Linda C. Sandin, David Robinson, Emma J. Davies, Vikki Flemington
Supplementary Figure 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d656816b18c3ad9cb8c303b7ebd7f0b
https://doi.org/10.1158/1535-7163.22521559
https://doi.org/10.1158/1535-7163.22521559
Autor:
Paul D. Smith, J. Elizabeth Pease, Sabina C. Cosulich, Iain Simpson, Richard A. Ward, Clifford D. Jones, Stephen E. Fawell, Mathew J. Garnett, Patricia Jaaks, Elizabeth A. Coker, Claire Rooney, Martine P. Roudier, Sophie E. Willis, Philip Hopcroft, Michael Tonge, Karen Roberts, Joanne Wilson, Aaron Smith, Nicola Lindsay, Francis D. Gibbons, Katarzyna Falenta, Sigourney Bell, Paul Farrington, Lyndsey Hanson, Pei Zhang, Oona Delpuech, Linda C. Sandin, David Robinson, Emma J. Davies, Vikki Flemington
KRAS mutation status of cell lines included in in vitro combination screen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2948856a623204b2bfff5869f7d00b5e
https://doi.org/10.1158/1535-7163.22521529.v1
https://doi.org/10.1158/1535-7163.22521529.v1
Autor:
Paul D. Smith, J. Elizabeth Pease, Sabina C. Cosulich, Iain Simpson, Richard A. Ward, Clifford D. Jones, Stephen E. Fawell, Mathew J. Garnett, Patricia Jaaks, Elizabeth A. Coker, Claire Rooney, Martine P. Roudier, Sophie E. Willis, Philip Hopcroft, Michael Tonge, Karen Roberts, Joanne Wilson, Aaron Smith, Nicola Lindsay, Francis D. Gibbons, Katarzyna Falenta, Sigourney Bell, Paul Farrington, Lyndsey Hanson, Pei Zhang, Oona Delpuech, Linda C. Sandin, David Robinson, Emma J. Davies, Vikki Flemington
The RAS-regulated RAF–MEK1/2–ERK1/2 (RAS/MAPK) signaling pathway is a major driver in oncogenesis and is frequently dysregulated in human cancers, primarily by mutations in BRAF or RAS genes. The clinical benefit of inhibitors of this pathway as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bdb35b33664ffcfa90648d650a5e76d
https://doi.org/10.1158/1535-7163.c.6543055.v1
https://doi.org/10.1158/1535-7163.c.6543055.v1
Autor:
Paul D. Smith, J. Elizabeth Pease, Sabina C. Cosulich, Iain Simpson, Richard A. Ward, Clifford D. Jones, Stephen E. Fawell, Mathew J. Garnett, Patricia Jaaks, Elizabeth A. Coker, Claire Rooney, Martine P. Roudier, Sophie E. Willis, Philip Hopcroft, Michael Tonge, Karen Roberts, Joanne Wilson, Aaron Smith, Nicola Lindsay, Francis D. Gibbons, Katarzyna Falenta, Sigourney Bell, Paul Farrington, Lyndsey Hanson, Pei Zhang, Oona Delpuech, Linda C. Sandin, David Robinson, Emma J. Davies, Vikki Flemington
Supplementary Figure 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16f46c618c3a5211c6970b472f7e487f
https://doi.org/10.1158/1535-7163.22521547
https://doi.org/10.1158/1535-7163.22521547
Autor:
Paul D. Smith, J. Elizabeth Pease, Sabina C. Cosulich, Iain Simpson, Richard A. Ward, Clifford D. Jones, Stephen E. Fawell, Mathew J. Garnett, Patricia Jaaks, Elizabeth A. Coker, Claire Rooney, Martine P. Roudier, Sophie E. Willis, Philip Hopcroft, Michael Tonge, Karen Roberts, Joanne Wilson, Aaron Smith, Nicola Lindsay, Francis D. Gibbons, Katarzyna Falenta, Sigourney Bell, Paul Farrington, Lyndsey Hanson, Pei Zhang, Oona Delpuech, Linda C. Sandin, David Robinson, Emma J. Davies, Vikki Flemington
Supplementary materials and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5b82dd79cbfd859f34b41f858212fb
https://doi.org/10.1158/1535-7163.22521526.v1
https://doi.org/10.1158/1535-7163.22521526.v1