Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Clifford C, Shone"'
Autor:
April K. Roberts, Hannah C. Harris, Michael Smith, Joanna Giles, Oktawia Polak, Anthony M. Buckley, Emma Clark, Duncan Ewin, Ines B. Moura, William Spitall, Clifford C. Shone, Mark Wilcox, Caroline Chilton, Rossen Donev
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Clostridioides difficile infection (CDI) is a toxin-mediated infection in the gut and a major burden on healthcare facilities worldwide. We rationalized that it would be beneficial to design an antibody therapy that is delivered to, and is active at
Externí odkaz:
https://doaj.org/article/1d79ddd9f6f34938b69e698e2927b838
Autor:
Cornelia Roesl, Elizabeth R. Evans, Kosala N. Dissanayake, Veronika Boczonadi, Ross A. Jones, Graeme R. Jordan, Leire Ledahawsky, Guy C. C. Allen, Molly Scott, Alanna Thomson, Thomas M. Wishart, David I. Hughes, Richard J. Mead, Clifford C. Shone, Clarke R. Slater, Thomas H. Gillingwater, Paul A. Skehel, Richard R. Ribchester
Publikováno v:
Biomolecules, Vol 11, Iss 10, p 1499 (2021)
Live imaging of neuromuscular junctions (NMJs) in situ has been constrained by the suitability of ligands for inert vital staining of motor nerve terminals. Here, we constructed several truncated derivatives of the tetanus toxin C-fragment (TetC) fus
Externí odkaz:
https://doaj.org/article/13eea35c1e66435fbc176e5c7bc2404b
Autor:
Marco Pirazzini, Domenico Azarnia Tehran, Giulia Zanetti, Aram Megighian, Michele Scorzeto, Silvia Fillo, Clifford C. Shone, Thomas Binz, Ornella Rossetto, Florigio Lista, Cesare Montecucco
Publikováno v:
Cell Reports, Vol 8, Iss 6, Pp 1870-1878 (2014)
Botulinum neurotoxins consist of a metalloprotease linked via a conserved interchain disulfide bond to a heavy chain responsible for neurospecific binding and translocation of the enzymatic domain in the nerve terminal cytosol. The metalloprotease ac
Externí odkaz:
https://doaj.org/article/2b65ebbe911044068d24c51c7fcb1948
Autor:
Guy C. C. Allen, Leire M. Ledahawsky, Elizabeth R. Evans, Molly Scott, Kosala N. Dissanayake, Clifford C. Shone, Paul Skehel, Veronika Boczonadi, Richard R. Ribchester, Ross A. Jones, Cornelia Roesl, Thomas M. Wishart, Graeme R. Jordan, Clarke R. Slater, Richard J. Mead, David Hughes, Alanna Thomson, Thomas H. Gillingwater
Publikováno v:
Biomolecules, Vol 11, Iss 1499, p 1499 (2021)
Biomolecules
Volume 11
Issue 10
Biomolecules
Volume 11
Issue 10
Live imaging of neuromuscular junctions (NMJs) in situ has been constrained by the suitability of ligands for inert vital staining of motor nerve terminals. Here, we constructed several truncated derivatives of the tetanus toxin C-fragment (TetC) fus
Autor:
Jay R. Laver, Konstantinos Belogiannis, Richard Hesp, Adam P. Dale, Anish K. Pandey, Robert C. Read, Clifford C. Shone
Publikováno v:
The Journal of Infection
OBJECTIVES: Escherichia coli is the leading cause of bacteraemia. In an era of emerging multi-drug-resistant strains, development of effective preventative strategies will be informed by knowledge of strain diversity associated with specific infectiv
Autor:
William Spitall, Caroline H. Chilton, April K. Roberts, Ines B Moura, Duncan Ewin, Clifford C. Shone, Emma Clark, Mark H. Wilcox, Hannah C Harris, Anthony M. Buckley, Rossen Donev, Oktawia J Polak, Michael Smith, Joanna L. Giles
Publikováno v:
Frontiers in Microbiology
Frontiers in Microbiology, Vol 11 (2020)
Frontiers in Microbiology, Vol 11 (2020)
Clostridioides difficile infection (CDI) is a toxin-mediated infection in the gut and a major burden on healthcare facilities worldwide. We rationalized that it would be beneficial to design an antibody therapy that is delivered to, and is active at
Publikováno v:
Journal of Cell Communication and Signaling
The nosocomially acquired pathogen Clostridium difficile is the primary causative agent of antibiotic associated diarrhoea and causes tens of thousands of deaths globally each year. C. difficile presents a paracrystalline protein array on the surface
Autor:
Mohamed R. Hamed, Clifford C. Shone, Brendon MacKenzie, K. Ravi Acharya, Tanya Monaghan, Ola H. Negm, Mark H. Wilcox, David P. Humphreys
Publikováno v:
Clinical and Experimental Gastroenterology. 10:169-175
Objectives: Despite multiple risk factors and a high rate of colonization for Clostridium difficile, the occurrence of C. difficile infection in patients with cystic fibrosis is rare. The aim of this study was to compare the prevalence of binding C.
Publikováno v:
Acta Crystallographica. Section F, Structural Biology Communications
Bradshaw, W J, Roberts, A K, Shone, C C & Acharya, K R 2015, ' Cwp84, a Clostridium difficile cysteine protease, exhibits conformational flexibility in the absence of its propeptide ', Acta Crystallographica Section F:Structural Biology Communications, vol. 71, pp. 295-303 . https://doi.org/10.1107/S2053230X15001065
Bradshaw, W J, Roberts, A K, Shone, C C & Acharya, K R 2015, ' Cwp84, a Clostridium difficile cysteine protease, exhibits conformational flexibility in the absence of its propeptide ', Acta Crystallographica Section F:Structural Biology Communications, vol. 71, pp. 295-303 . https://doi.org/10.1107/S2053230X15001065
Two structures of Cwp84, a cysteine protease from the S-layer of C. difficile, are presented after propeptide cleavage. They reveal the movement of three loops, two in the active-site groove and one on the surface of the lectin-like domain, exposing
Publikováno v:
The Febs Journal
Clostridium difficile is a burden to healthcare systems around the world, causing tens of thousands of deaths annually. The S‐layer of the bacterium, a layer of protein found of the surface of cells, has received a significant amount of attention o