Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Clifford B. Longley"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:2251-2254
The moenomycin trisaccharide degradation product and synthetic disaccharide analogues based on the disaccharide core were bactericidal to Gram-positive bacteria, inhibited lipid II polymerization, and inhibited cell wall synthesis in Entercoccus faec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373e9d6be2230072bf2693f5cb5ba5ab
https://doi.org/10.1016/s0960-894x(00)00443-1
https://doi.org/10.1016/s0960-894x(00)00443-1
Autor:
Sunita Midha, Clifford B. Longley, Kiho Han, Helena R. Axelrod, Arthur A. Branstrom, Eugene R. Baizman
Publikováno v:
Analytical Biochemistry. 280:315-319
Bacterial peptidoglycan synthesis is a well-characterized system for targeting new antimicrobial drugs. Formation of the peptidoglycan precursors Lipid I and Lipid II is catalyzed by the gene products of mraY and murG, which are involved in the first
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc5ab22bdfde0ce7fd12bc2b055a85c5
https://doi.org/10.1006/abio.2000.4530
https://doi.org/10.1006/abio.2000.4530
Publikováno v:
FEMS Microbiology Letters. 183:209-214
Novel glycopeptide analogs are known that have activity on vancomycin resistant enterococci despite the fact that the primary site for drug interaction, D-ala-D-ala, is replaced with D-ala-D-lactate. The mechanism of action of these compounds may inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe7f26971f4f4fd0dbfccf6c98fdaa0
https://doi.org/10.1111/j.1574-6968.2000.tb08959.x
https://doi.org/10.1111/j.1574-6968.2000.tb08959.x
Autor:
Rui Liang, Chunguang Wang, Kiho Han, Nicole T. Hatzenbuhler, Buwen Huang, Muthoni G. Kamau, Helena R. Axelrod, Jan A. Anderson, Ramesh Kakarla, Neil Bristol, Anna Chen, Domingos J. Silva, Arthur Branstrom, Robert D. Goldman, Richard G. Dulina, Huiming Wang, Feng Chi, David Gange, Clifford B. Longley, Michael J. Sofia, Nigel M. Allanson, Dashan Liu, Rakesh K. Jain, Eugene R. Baizman, Natan A. Kogan, Sunita Midha
Publikováno v:
Journal of Medicinal Chemistry. 42:3193-3198
The increase in bacterial resistance to conventional chemotherapy has resulted in a resurgent interest in the discovery and development of antibacterial agents.1-4 The search for novel antibiotics active against resistant phenotypes is increasingly f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae445443dbe326863e7cdf3e76e733bc
https://doi.org/10.1021/jm990212a
https://doi.org/10.1021/jm990212a
Autor:
Babu Suresh D, Leigh Wierichs, Suzanne Walker, Natan A. Kogan, Michael J. Sofia, Karen Bruker, Ramesh Kakarla, Helena R. Axelrod, Clifford B. Longley, Sunita Midha, Daniel Kahne
Publikováno v:
Proceedings of the National Academy of Sciences. 93:1585-1590
A promising class of compounds for DNA transfection have been designed by conjugating various polyamines to bile-acid-based amphiphiles. Formulations containing these compounds were tested for their ability to facilitate the uptake of a beta-galactos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8205ded88c6b73d16ebf384df7cea67d
https://doi.org/10.1073/pnas.93.4.1585
https://doi.org/10.1073/pnas.93.4.1585
Autor:
Evgenia N Olsufyeva, Andrey Y. Pavlov, Robert C. Goldman, M. I. Reznikova, Eugene R. Baizman, Gyula Batta, Ferenc Sztaricskai, Maria N. Preobrazhenskaya, Clifford B. Longley, Elena B. Isakova, Arthur A. Branstrom, Elena P. Mirchink, Svetlana S. Printsevskaya
Publikováno v:
Journal of medicinal chemistry. 45(6)
Des-(N-methyl-D-leucyl)eremomycin was obtained by Edman degradation of eremomycin. Derivatives with a hydrophobic substituent at the exterior of the molecule were then synthesized, and their antibacterial activities were compared with similar derivat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bf9ca7d53c1f4d6ae9e5afb86dddc17
https://pubmed.ncbi.nlm.nih.gov/11882003
https://pubmed.ncbi.nlm.nih.gov/11882003
Autor:
Charlotte A. Burton, Michiel E. Ultee, Geoffrey W. Henson, Sreenivasan Padmanabhan, Forrest E. Gaul, Michael J. Abrams, Gary Bridger, David A. Schwartz, Clifford B. Longley, Scott K. Larsen
Publikováno v:
Bioconjugate chemistry. 7(2)
The design and synthesis of hydrazinopyridine bifunctional chelating agents (BCA's) featuring amide, ester, and disulfide groups are described. The BCA's site-specifically react with the free thiol groups of the tumor-specific monoclonal antibody fra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dafa8049011c63de03c68143d51ba8d
https://pubmed.ncbi.nlm.nih.gov/8983348
https://pubmed.ncbi.nlm.nih.gov/8983348