Validation of NASH-CHECK: a novel patient-reported outcome measure for nonalcoholic steatohepatitis

Autor: James Twiss, Diane Whalley, Lynda Doward, Maria-Magdalena Balp, Clifford A. Brass, Donna Cryer, Arun Sanyal, Quentin M. Anstee

Publikováno v: Journal of Patient-Reported Outcomes, Vol 7, Iss 1, Pp 1-14 (2023)

Abstract Background Standardized measures for evaluating patients’ experiences with nonalcoholic steatohepatitis (NASH) and their perceived changes with treatment in clinical trials have been limited. To meet this need, a patient-reported outcome (

Externí odkaz: https://doaj.org/article/8b44ccc2a203433ba698e8da08c32158

Tropifexor for nonalcoholic steatohepatitis: an adaptive, randomized, placebo-controlled phase 2a/b trial

Autor: Arun J. Sanyal, Patricia Lopez, Eric J. Lawitz, Kathryn J. Lucas, Juergen Loeffler, Won Kim, George B. B. Goh, Jee-Fu Huang, Carla Serra, Pietro Andreone, Yi-Cheng Chen, Stanley H. Hsia, Vlad Ratziu, Diego Aizenberg, Hiroshi Tobita, Aasim M. Sheikh, John M. Vierling, Yoon Jun Kim, Hideyuki Hyogo, Dean Tai, Zachary Goodman, Felicity Schaefer, Ian R. I. Carbarns, Sophie Lamle, Miljen Martic, Nikolai V. Naoumov, Clifford A. Brass

Publikováno v: Nature Medicine. 29:392-400

The multimodal activities of farnesoid X receptor (FXR) agonists make this class an attractive option to treat nonalcoholic steatohepatitis. The safety and efficacy of tropifexor, an FXR agonist, in a randomized, multicenter, double-blind, three-part

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1dc2773f3efdbc3a1d53a40666606e76
https://doi.org/10.1038/s41591-022-02200-8

Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance

Autor: Raluca Pais, Rachel Ostroff, Stephen Harrison, Lars Friis Mikkelsen, Elisabeth Erhardtsen, Sudha Shankar, Kimmo Porthan, Jérôme Boursier, Antonia Sinisi, Michael Kalutkiewicz, Sven Francque, Miljen Martic, Vanessa Pellegrinelli, Phil N. Newsome, Guido Hanauer, Hannele Yki-Järvinen, Rebecca Darlay, Joel Myers, Carla Yunis, Salvatore Petta, Mette Skalshøi Kjær, Pablo Ortiz, Ann K. Daly, James H. Clark, Dina Tiniakos, Yasaman Vali, Hadi Zafarmand, Matej Orešič, Maurizio Parola, Estelle Sandt, Lori L. Jennings, Matt Kelly, Tuulia Hyötyläinen, Detlef Schuppan, Céline Fournier, Chiara Rosso, Diane E. Shevell, Maria Manuela Tonini, Paul Hockings, Aidan McGlinchey, Salma Akhtar, Mette Juul Fisker, Morten A. Karsdal, Diane Whalley, Melissa R. Miller, Aldo Trylesinski, Mattias Ekstedt, Stefan Neubauer, Jeremy M. Palmer, Partho Sen, Michael Pavlides, Per Qvist, Isabel Fernández, Luca Miele, Fabio Marra, Stergios Kechagias, Richard Torstenson, Katherine Johnson, Jean-François Dufour, Elisabetta Bugianesi, M. Julia Brosnan, George V. Papatheodoridis, Kay M. Pepin, Daniel Guldager Kring Rasmussen, Henrik Landgren, Rachel Queen, Simon Cockell, Michael Allison, Patrick M.M. Bossuyt, Rocío Gallego-Durán, Christian Rosenquist, Leigh Alexander, Elizabeth Shumbayawonda, Michele Vacca, Antonio Vidal-Puig, David Wenn, Rémy Hanf, Oscar Millet, Michalina Zatorska, R. Myers, José M. Mato, Jenny Lee, Theresa Tuthill, James Twiss, Ramy Younes, Peter Leary, Lynda Doward, Kristy Wonders, Guruprasad P. Aithal, Sarah Charlton, Vlad Ratziu, Cecília M. P. Rodrigues, Christian Trautwein, Helena Cortez-Pinto, Gideon Ho, Matt J. Barter, Judith Ertle, Jörn M. Schattenberg, Maria-Magdalena Balp, Yang-Lin Liu, Clifford A. Brass, Olivier Govaere, Amalia Gastaldelli, Sergio Rodriguez Cuenca, Pierre Chaumat, Fiona Oakley, Luca Valenti, Simon J. Cockell, Saskia W.C. van Mil, Ferenc E. Mózes, Andreas Geier, Timothy Hardy, Pierre Bedossa, Andrea Dennis, Richard L. Ehman, Charlotte Erpicum, Karine Clément, Jeremy F. L. Cobbold, Christopher P. Day, Rajarshi Banerjee, Manuel Romero-Gómez, Quentin M. Anstee, Adriaan G. Holleboom, Heather J. Cordell, Kevin L. Duffin, Diana Julie Leeming

Publikováno v: JHEP Reports, 4(2):100409. Elsevier
JHEP Reports
JHEP Reports, Vol 4, Iss 2, Pp 100409-(2022)
JHEP reports 4(2), 100409 (2022). doi:10.1016/j.jhepr.2021.100409

Background & Aims Serum microRNA (miRNA) levels are known to change in non-alcoholic fatty liver disease (NAFLD) and may serve as useful biomarkers. This study aimed to profile miRNAs comprehensively at all NAFLD stages. Methods We profiled 2,083 ser

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c39a3a5921e0d464a7b2b93c40ef52c
https://pure.amc.nl/en/publications/increased-serum-mir193a5p-during-nonalcoholic-fatty-liver-disease-progression(bd6dd66c-d686-4b4d-be46-956a848f1f3b).html

The journey of a patient with biopsy-proven non-alcoholic steatohepatitis (NASH) – results from a real-world study

Autor: Raymond Przybysz, Andreas Geier, Vlad Ratziu, S.J. Mckenna, M. Gavaghan, D. Rosen, J. Cai, M Balp, T. Howe, Mary E. Rinella, A. Knight, Clifford A. Brass

Publikováno v: 35. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::834ad0f9fce8004c070699f2157cbd67
https://doi.org/10.1055/s-0038-1677147

SAT-357-Tropifexor, a farnesoid X receptor agonist for the treatment of non-alcoholic steatohepatitis: Interim results based on baseline body mass index from first two parts of Phase 2b study FLIGHT-FXR

Autor: Arun J. Sanyal, Yi-Cheng Chen, Juergen Loeffler, Pietro Andreone, Eric Lawitz, Vlad Ratziu, Won-Seog Kim, Jee-Fu Huang, Marno Ryan, Patricia Lopez, Clifford A. Brass, Yoon Jun Kim, Felicity Schaefer, Miljen Martic, George Boon Bee Goh, Andreas Geier, Martin Weltman, Sujata Vaidyanathan

Publikováno v: Journal of Hepatology. 70:e796-e797

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58e70f732d29f9f834ff505b3c69f02e
https://doi.org/10.1016/s0618-8278(19)31587-7