Machine learning approaches to enhance diagnosis and staging of patients with MASLD using routinely available clinical information.

Autor: Matthew McTeer, Douglas Applegate, Peter Mesenbrink, Vlad Ratziu, Jörn M Schattenberg, Elisabetta Bugianesi, Andreas Geier, Manuel Romero Gomez, Jean-Francois Dufour, Mattias Ekstedt, Sven Francque, Hannele Yki-Jarvinen, Michael Allison, Luca Valenti, Luca Miele, Michael Pavlides, Jeremy Cobbold, Georgios Papatheodoridis, Adriaan G Holleboom, Dina Tiniakos, Clifford Brass, Quentin M Anstee, Paolo Missier, LITMUS Consortium investigators

Publikováno v: PLoS ONE, Vol 19, Iss 2, p e0299487 (2024)

AimsMetabolic dysfunction Associated Steatotic Liver Disease (MASLD) outcomes such as MASH (metabolic dysfunction associated steatohepatitis), fibrosis and cirrhosis are ordinarily determined by resource-intensive and invasive biopsies. We aim to sho

Externí odkaz: https://doaj.org/article/67ecf06493dd4d75bdee07628520f62d

The Cost of Diagnosing and Managing Non-alcoholic Steatohepatitis in Europe and the United States

Autor: Andreas, Geier, Sabina, Heinz, Maria-Magdalena, Balp, Clifford, Brass, Marcos, Pedrosa, Jennifer, Cai, Rachel, Hoad, Aram-Christopher, Sayadian, Mary, Rinella, Vlad, Ratziu

Publikováno v: Journal of Gastrointestinal and Liver Diseases. 31:317-322

Background and Aims: Non-alcoholic steatohepatitis (NASH) is acknowledged as a severe disease that is associated with a significant burden on patients, payers, and society. However, limited evidence exists on the cost associated with NASH across diff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72b1d267c8fb9419f2486ad63dbdfb8c
https://doi.org/10.15403/jgld-4275

Biomarkers for staging fibrosis and non-alcoholic steatohepatitis in non-alcoholic fatty liver disease (the LITMUS project): a comparative diagnostic accuracy study

Autor: Yasaman Vali, Jenny Lee, Jerome Boursier, Salvatore Petta, Kristy Wonders, Dina Tiniakos, Pierre Bedossa, Andreas Geier, Sven Francque, Mike Allison, Georgios Papatheodoridis, Helena Cortez-Pinto, Raluca Pais, Jean-Francois Dufour, Diana Julie Leeming, Stephen A Harrison, Yu Chen, Jeremy F Cobbold, Michael Pavlides, Adriaan G Holleboom, Hannele Yki-Jarvinen, Javier Crespo, Morten Karsdal, Rachel Ostroff, Mohammad Hadi Zafarmand, Richard Torstenson, Kevin Duffin, Carla Yunis, Clifford Brass, Mattias Ekstedt, Guruprasad P Aithal, Jörn M Schattenberg, Elisabetta Bugianesi, Manuel Romero-Gomez, Vlad Ratziu, Quentin M Anstee, Patrick M Bossuyt

Publikováno v: lancet. Gastroenterology & hepatology. Elsevier Limited
Vali, Yasaman; Lee, Jenny; Boursier, Jerome; Petta, Salvatore; Wonders, Kristy; Tiniakos, Dina; Bedossa, Pierre; Geier, Andreas; Francque, Sven; Allison, Mike; Papatheodoridis, Georgios; Cortez-Pinto, Helena; Pais, Raluca; Dufour, Jean-Francois; Leeming, Diana Julie; Harrison, Stephen A; Chen, Yu; Cobbold, Jeremy F; Pavlides, Michael; Holleboom, Adriaan G; ... (2023). Biomarkers for staging fibrosis and non-alcoholic steatohepatitis in non-alcoholic fatty liver disease (the LITMUS project): a comparative diagnostic accuracy study. The lancet. Gastroenterology & hepatology, 8(8), pp. 714-725. Elsevier 10.1016/S2468-1253(23)00017-1

BACKGROUND The reference standard for detecting non-alcoholic steatohepatitis (NASH) and staging fibrosis-liver biopsy-is invasive and resource intensive. Non-invasive biomarkers are urgently needed, but few studies have compared these biomarkers in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e5804b97ea21d329f8be39ff3820775
https://pure.amc.nl/en/publications/biomarkers-for-staging-fibrosis-and-nonalcoholic-steatohepatitis-in-nonalcoholic-fatty-liver-disease-the-litmus-project(ec377298-92db-4611-8b8e-8f9f2f3e8216).html

Second harmonic generation microscopy can quantify and subclassify early stages of NASH fibrosis progression: data from a screen-failure cohort of a NASH phase 2 study

Autor: Dominique Brees, Dean Tai, Clifford Brass, Nikolai Naoumov, Elaine Chng, Yayun Ren, Andreas Sailer, Douglas Applegate, Jossy George Kochuparampil, Juergen Loeffler, Li Chen, Miljen Martic, Zachary Goodman, Marcos Pedrosa, Quentin Anstee

Publikováno v: Journal of Hepatology. 77:S486-S487

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a7a30f28836381c96cf7dab1de3806f
https://doi.org/10.1016/s0168-8278(22)01304-6

Patient-reported symptoms and impact in non-alcoholic steatohepatitis: an evaluation of the NASH-check, a novel prom in NASH

Autor: Diane Whalley, James Twiss, Lynda Doward, Maria Magdalena Balp, Clifford Brass, Juergen Loeffler, Patricia Lopez, Jennifer Cai, Donna Cryer, Quentin Anstee, Arun Sanyal

Publikováno v: Journal of Hepatology. 73:S422-S423

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d4a1d53dc2fe236ab218b1a49151f24
https://doi.org/10.1016/s0168-8278(20)31328-3