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Autor:
Vijay Sabesan, Aleksey Zaks, Cliff Levy, David R. Dodds, Michael J. Homann, Brian Morgan, Robert B. Vail
Publikováno v:
Advanced Synthesis & Catalysis. 343:744-749
An enzymatic process for desymmetrization of the prochiral diethyl 3-[3',4'-dichlorophenyl]glutarate, 1, an intermediate in the synthesis of a series of neurokinin (NK) receptor antagonists, has been developed and scaled up. The transformation cataly