Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Cliff J. Luke"'
Autor:
Zachary D. Dawson, Hemalatha Sundaramoorthi, Suk Regmi, Bo Zhang, Stephanie Morrison, Sara M. Fielder, Jessie R. Zhang, Hieu Hoang, David H. Perlmutter, Cliff J. Luke, Gary A. Silverman, Stephen C. Pak
Publikováno v:
Autophagy Reports, Vol 3, Iss 1 (2024)
Autophagy is important for many physiological processes; and disordered autophagy can contribute to the pathogenesis of a broad range of systemic disorders. C. elegans is a useful model organism for studying the genetics of autophagy, however, curren
Externí odkaz:
https://doaj.org/article/50031cc4024141b38ff18745781f19c2
Autor:
Fan Yang, Mingyi Suo, Homayemem Weli, Mason Wong, Alex Junidi, Celeste Cummings, Ryan Johnson, Kiara Mallory, Annie Y. Liu, Zev J. Greenberg, Laura G. Schuettpelz, Mark J. Miller, Cliff J. Luke, Gwendalyn J. Randolph, Bernd H. Zinselmeyer, Juliane Bubeck Wardenburg, Regina A. Clemens
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113394- (2023)
Summary: The pore-forming S. aureus α-toxin (Hla) contributes to virulence and disease pathogenesis. While high concentrations of toxin induce cell death, neutrophils exhibit relative resistance to lysis, suggesting that the action of Hla may not be
Externí odkaz:
https://doaj.org/article/8ce12c2e775c4ee4b7824ce089eedc43
Autor:
Wyatt E. Lanik, Cliff J. Luke, Lila S. Nolan, Qingqing Gong, Lauren C. Frazer, Jamie M. Rimer, Sarah E. Gale, Raymond Luc, Shay S. Bidani, Carrie A. Sibbald, Angela N. Lewis, Belgacem Mihi, Pranjal Agrawal, Martin Goree, Marlie Maestas, Elise Hu, David G. Peters, Misty Good
Publikováno v:
JCI Insight, Vol 8, Iss 8 (2023)
Necrotizing enterocolitis (NEC) is a deadly gastrointestinal disease of premature infants that is associated with an exaggerated inflammatory response, dysbiosis of the gut microbiome, decreased epithelial cell proliferation, and gut barrier disrupti
Externí odkaz:
https://doaj.org/article/8016507d4d3a4af39d3df3252b403b98
Autor:
Cliff J. Luke, Stephanie Markovina, Misty Good, Ira E. Wight, Brian J. Thomas, John M. Linneman, Wyatt E. Lanik, Olga Koroleva, Maggie R. Coffman, Mark T. Miedel, Qingqing Gong, Arlise Andress, Marlene Campos Guerrero, Songyan Wang, LiYun Chen, Wandy L. Beatty, Kelsey N. Hausmann, Frances V. White, James A. J. Fitzpatrick, Anthony Orvedahl, Stephen C. Pak, Gary A. Silverman
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-25 (2022)
Cliff Luke et al. report that lysoptosis is a eukaryotic stand-alone regulated cell death pathway. They identify that this new cell death modality predominates in the absence of neutralizing endogenous inhibitors.
Externí odkaz:
https://doaj.org/article/7e00cda7e5e545eb92702dd4e824bf73
Autor:
Songyan Wang, Cliff J. Luke, Stephen C. Pak, Victoria Shi, Liyun Chen, Jonathan Moore, Arlise P. Andress, Kay Jayachandran, Jin Zhang, Yi Huang, Marina Platik, Anthony A. Apicelli, Julie K. Schwarz, Perry W. Grigsby, Gary A. Silverman, Stephanie Markovina
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-16 (2022)
Wang et al. demonstrate the cytoprotective role of SERPINB3 against radiation-induced necrosis, showing that cells lacking SERPINB3 protein both in culture and in mice are more sensitive to radiation and cisplatin-induced cell death. The authors also
Externí odkaz:
https://doaj.org/article/125c4804dd504bf099b34a577102b07a
Autor:
Belgacem Mihi, Qingqing Gong, Lila S. Nolan, Sarah E. Gale, Martin Goree, Elise Hu, Wyatt E. Lanik, Jamie M. Rimer, Victoria Liu, Olivia B. Parks, Angela N. Lewis, Pranjal Agrawal, Marie L. Laury, Pawan Kumar, Elizabeth Huang, Shay S. Bidani, Cliff J. Luke, Jay K. Kolls, Misty Good
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 6, Pp 100320- (2021)
Summary: Necrotizing enterocolitis (NEC) is a deadly intestinal inflammatory disorder that primarily affects premature infants and lacks adequate therapeutics. Interleukin (IL)-22 plays a critical role in gut barrier maintenance, promoting epithelial
Externí odkaz:
https://doaj.org/article/a0628f72e8444ea39ed9638a247b9f0b
Autor:
Guoying Zhu, Steven J Wilhelm, Leah G George, Brett M Cassidy, Sammy Zino, Cliff J Luke, Mina Hanna, Stephen Stone, Nhung Phan, Neel Matiwala, Samuel J Ballentine, Mark E Lowe, Xunjun Xiao
Publikováno v:
Gut
ObjectiveIncreasing evidence implicates mutation-induced protein misfolding and endoplasm reticulum (ER) stress in the pathophysiology of chronic pancreatitis (CP). The paucity of animal models harbouring genetic risk variants has hampered our unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1fc1e135fb286ceb6ceda820f41222a
https://europepmc.org/articles/PMC10257759/
https://europepmc.org/articles/PMC10257759/
Autor:
Zev J. Greenberg, Luana Chiquetto Paracatu, Darlene A. Monlish, Qian Dong, Michael Rettig, Nate Roundy, Rofaida Gaballa, Weikai Li, Wei Yang, Cliff J. Luke, Laura G. Schuettpelz
Publikováno v:
Blood.
The hematopoietic stem cell (HSC) cycle responds to inflammatory and other proliferative stressors; however, these cells must quickly return to quiescence to avoid exhaustion and maintain their functional integrity. The mechanisms that regulate this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::482682a0fa4f36cdd7670d3c8ac724b2
https://pubmed.ncbi.nlm.nih.gov/36542833
https://pubmed.ncbi.nlm.nih.gov/36542833
Autor:
Ping Yang, Hillary B. Heins, Frances V. White, Daniel J. Wegner, Cliff J. Luke, Fuhai Li, F. Sessions Cole, Jennifer A. Wambach
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 63:436-443
Rare or private, biallelic variants in the ABCA3 (ATP-binding cassette transporter A3) gene are the most common monogenic cause of lethal neonatal respiratory failure and childhood interstitial lun...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bffddbb28690d3d85bdd3edca395a7f9
https://doi.org/10.1165/rcmb.2020-0034ma
https://doi.org/10.1165/rcmb.2020-0034ma
Autor:
Cliff J. Luke, Ping Yang, Fuhai Li, June Y. Hu, F. Sessions Cole, Frances V. White, Hillary B. Heins, Gary A. Silverman, Jennifer A. Wambach, Daniel J. Wegner
Publikováno v:
Hum Mutat
ABCA3 transports phospholipids across lamellar body membranes in pulmonary alveolar type II cells and is required for surfactant assembly. Rare, biallelic, pathogenic ABCA3 variants result in lethal neonatal respiratory distress syndrome and childhoo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e4b680994cc4e5922d28d0d8ecc212
https://doi.org/10.1002/humu.24014
https://doi.org/10.1002/humu.24014