Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Cleydson B. R. Santos"'
Autor:
Vitor H. da S. Sanches, Cleison C. Lobato, Luciane B. Silva, Igor V. F. dos Santos, Elcimar de S. Barros, Alexandre de A. Maciel, Elenilze F. B. Ferreira, Kauê S. da Costa, José M. Espejo-Román, Joaquín M. C. Rosa, Njogu M. Kimani, Cleydson B. R. Santos
Publikováno v:
Pharmaceuticals, Vol 17, Iss 11, p 1491 (2024)
Background: This study began with a search in three databases, totaling six libraries (ChemBridge-DIVERSet, ChemBridge-DIVERSet-EXP, Zinc_Drug Database, Zinc_Natural_Stock, Zinc_FDA_BindingDB, Maybridge) with approximately 2.5 million compounds with
Externí odkaz:
https://doaj.org/article/5f7c8bca40554033a04fbfda67b2bcf8
Autor:
Wilberforce Ndarawit, Charles Otieno Ochieng, David Angwenyi, Jorddy N. Cruz, Cleydson B. R. Santos, Njogu M. Kimani
Publikováno v:
PLoS ONE, Vol 19, Iss 11 (2024)
Externí odkaz:
https://doaj.org/article/c65d52859ac746b490640fd8f4a5923a
Autor:
Shadrack Kibet, Njogu M. Kimani, Syombua S. Mwanza, Cynthia M. Mudalungu, Cleydson B. R. Santos, Chrysantus M. Tanga
Publikováno v:
Pharmaceuticals, Vol 17, Iss 4, p 510 (2024)
Natural products hold immense potential for drug discovery, yet many remain unexplored in vast libraries and databases. In an attempt to fill this gap and meet the growing demand for effective drugs, this study delves into the promising world of ent-
Externí odkaz:
https://doaj.org/article/9aa23da98e3142aaa97b6b985b4abafb
Autor:
Njogu M. Kimani, Charles O. Ochieng, Mike Don Ogutu, Kevin Otieno Yamo, Joab Otieno Onyango, Cleydson B. R. Santos
Publikováno v:
Journal of Xenobiotics, Vol 13, Iss 1, Pp 102-120 (2023)
Compounds from Zanthoxylum chalybeum Engl. were previously reported for inhibitory activities of amylase and glucosidase enzymatic action on starch as a preliminary study toward the establishment of a management strategy against postprandial hypergly
Externí odkaz:
https://doaj.org/article/ccf770dd614c4b919b3eff6bd054bedf
Autor:
Deyse B. Barbosa, Mayra R. do Bomfim, Tiago A. de Oliveira, Alisson M. da Silva, Alex G. Taranto, Jorddy N. Cruz, Paulo B. de Carvalho, Joaquín M. Campos, Cleydson B. R. Santos, Franco H. A. Leite
Publikováno v:
Pharmaceuticals, Vol 16, Iss 12, p 1657 (2023)
Alzheimer’s disease causes chronic neurodegeneration and is the leading cause of dementia in the world. The causes of this disease are not fully understood but seem to involve two essential cerebral pathways: cholinergic and amyloid. The simultaneo
Externí odkaz:
https://doaj.org/article/fdd4fbc549674dd0b53eb8d1d2cef958
Autor:
Cleydson B. R. Santos, Cleison C. Lobato, Sirlene S. B. Ota, Rai C. Silva, Renata C. V. S. Bittencourt, Jofre J. S. Freitas, Elenilze F. B. Ferreira, Marília B. Ferreira, Renata C. Silva, Anderson B. De Lima, Joaquín M. Campos, Rosivaldo S. Borges, José A. H. M. Bittencourt
Publikováno v:
Pharmaceuticals, Vol 16, Iss 11, p 1584 (2023)
The design, synthesis, and evaluation of novel non-steroidal anti-inflammatory drugs (NSAIDs) with better activity and lower side effects are big challenges today. In this work, two 5-acetamido-2-hydroxy benzoic acid derivatives were proposed, increa
Externí odkaz:
https://doaj.org/article/3c7c83face0f40d4a86f319b8878dae4
Autor:
Lana P. S. Oliveira, Lúcio R. Lima, Luciane B. Silva, Jorddy N. Cruz, Ryan S. Ramos, Luciana S. Lima, Francy M. N. Cardoso, Aderaldo V. Silva, Dália P. Rodrigues, Gabriela S. Rodrigues, Aldo A. Proietti-Junior, Gabriela B. dos Santos, Joaquín M. Campos, Cleydson B. R. Santos
Publikováno v:
Pharmaceuticals, Vol 16, Iss 10, p 1430 (2023)
Staphylococcus aureus is a microorganism with high morbidity and mortality due to antibiotic-resistant strains, making the search for new therapeutic options urgent. In this context, computational drug design can facilitate the drug discovery process
Externí odkaz:
https://doaj.org/article/eaffc86f2be74ad7aac4805b3a84ba51
Galantamine Based Novel Acetylcholinesterase Enzyme Inhibitors: A Molecular Modeling Design Approach
Autor:
Luciane B. Silva, Elenilze F. B. Ferreira, Maryam, José M. Espejo-Román, Glauber V. Costa, Josiane V. Cruz, Njogu M. Kimani, Josivan S. Costa, José A. H. M. Bittencourt, Jorddy N. Cruz, Joaquín M. Campos, Cleydson B. R. Santos
Publikováno v:
Molecules, Vol 28, Iss 3, p 1035 (2023)
Acetylcholinesterase (AChE) enzymes play an essential role in the development of Alzheimer’s disease (AD). Its excessive activity causes several neuronal problems, particularly psychopathies and neuronal cell death. A bioactive pose on the hAChE B
Externí odkaz:
https://doaj.org/article/dc71a5ccb35141a8b7192fc4f562a8a2
Autor:
Raquel B. M. de Almeida, Deyse B. Barbosa, Mayra R. do Bomfim, Jéssika A. O. Amparo, Bruno S. Andrade, Silvia L. Costa, Joaquín M. Campos, Jorddy N. Cruz, Cleydson B. R. Santos, Franco H. A. Leite, Mariana B. Botura
Publikováno v:
Pharmaceuticals, Vol 16, Iss 1, p 95 (2023)
The enhancement of cholinergic functions via acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibition is considered a valuable therapeutic strategy for the treatment of Alzheimer’s disease. This study aimed to evaluate the in vitro
Externí odkaz:
https://doaj.org/article/6e346028fd874c07af33ade6de3f30a1
Autor:
Moysés F. A. Neto, Joaquín M. Campos, Amanda P. M. Cerqueira, Lucio R. de Lima, Glauber V. Da Costa, Ryan Da S. Ramos, Jairo T. Magalhães Junior, Cleydson B. R. Santos, Franco H. A. Leite
Publikováno v:
Molecules, Vol 27, Iss 20, p 6777 (2022)
The Aedes aegypti mosquito is the main hematophagous vector responsible for arbovirus transmission in Brazil. The disruption of A. aegypti hematophagy remains one of the most efficient and least toxic methods against these diseases and, therefore, ef
Externí odkaz:
https://doaj.org/article/1b0a6e502b2e475486d403baca8bc3fd