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Uncovering the mode of action of engineered T cells in patient cancer organoids.

Autor: Dekkers, Johanna F., Alieva, Maria, Cleven, Astrid, Keramati, Farid, Wezenaar, Amber K. L., van Vliet, Esmée J., Puschhof, Jens, Brazda, Peter, Johanna, Inez, Meringa, Angelo D., Rebel, Heggert G., Buchholz, Maj-Britt, Barrera Román, Mario, Zeeman, Amber L., de Blank, Sam, Fasci, Domenico, Geurts, Maarten H., Cornel, Annelisa M., Driehuis, Else, Millen, Rosemary

Publikováno v: Nature Biotechnology; Jan2023, Vol. 41 Issue 1, p60-69, 10p

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Dual targeting of cancer metabolome and stress antigens affects transcriptomic heterogeneity and efficacy of engineered T cells.

Autor: Hernández-López P; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., van Diest E; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Brazda P; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Heijhuurs S; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Meringa A; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Hoorens van Heyningen L; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Riillo C; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.; Department of Experimental and Clinical Medicine, Magna Græcia University, Catanzaro, Italy., Schwenzel C; Faculty of Biology, University of Freiburg, Freiburg, Germany.; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.; Center of Chronic Immunodeficiency (CCI) and Institute for Immunodeficiency, University Clinics and Medical Faculty, Freiburg, Germany., Zintchenko M; Faculty of Biology, University of Freiburg, Freiburg, Germany.; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.; Center of Chronic Immunodeficiency (CCI) and Institute for Immunodeficiency, University Clinics and Medical Faculty, Freiburg, Germany., Johanna I; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Nicolasen MJT; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Cleven A; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Kluiver TA; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Millen R; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), Utrecht, the Netherlands., Zheng J; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Karaiskaki F; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Straetemans T; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Clevers H; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), Utrecht, the Netherlands.; Roche Pharmaceutical Research and Early Development, Basel, Switzerland., de Bree R; Department of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht, the Netherlands., Stunnenberg HG; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Peng WC; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Roodhart J; Department of Medical Oncology, University Medical Center Utrecht, Utrecht, the Netherlands., Minguet S; Faculty of Biology, University of Freiburg, Freiburg, Germany.; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.; Center of Chronic Immunodeficiency (CCI) and Institute for Immunodeficiency, University Clinics and Medical Faculty, Freiburg, Germany., Sebestyén Z; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Beringer DX; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Kuball J; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. j.h.e.kuball@umcutrecht.nl.; Department of Hematology, University Medical Center Utrecht, Utrecht, the Netherlands. j.h.e.kuball@umcutrecht.nl.

Publikováno v: Nature immunology [Nat Immunol] 2024 Jan; Vol. 25 (1), pp. 88-101. Date of Electronic Publication: 2023 Nov 27.